Maternal diet during pregnancy and adaptive changes in the maternal and fetal pancreas have implications for future metabolic health

Autor: David J. Hill, Thomas G. Hill

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Fetal and neonatal development is a critical period for the establishment of the future metabolic health and disease risk of an individual. Both maternal undernutrition and overnutrition can result in abnormal fetal organ development resulting in ina

Externí odkaz: https://doaj.org/article/bb54dcbfbca64211958271f1171d7839

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

Autor: Angela Kim, Jakob G Knudsen, Joseph C Madara, Anna Benrick, Thomas G Hill, Lina Abdul Kadir, Joely A Kellard, Lisa Mellander, Caroline Miranda, Haopeng Lin, Timothy James, Kinga Suba, Aliya F Spigelman, Yanling Wu, Patrick E MacDonald, Ingrid Wernstedt Asterholm, Tore Magnussen, Mikkel Christensen, Tina Vilsbøll, Victoria Salem, Filip K Knop, Patrik Rorsman, Bradford B Lowell, Linford JB Briant

Publikováno v: eLife, Vol 10 (2021)

Insulin-induced hypoglycemia is a major treatment barrier in type-1 diabetes (T1D). Accordingly, it is important that we understand the mechanisms regulating the circulating levels of glucagon. Varying glucose over the range of concentrations that oc

Externí odkaz: https://doaj.org/article/706e44ec35864e4a845aaa9f2824dfba

Low extracellular magnesium does not impair glucose-stimulated insulin secretion.

Autor: Lisanne M M Gommers, Thomas G Hill, Frances M Ashcroft, Jeroen H F de Baaij

Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0217925 (2019)

There is an increasing amount of clinical evidence that hypomagnesemia (serum Mg2+ levels < 0.7 mmol/l) contributes to type 2 diabetes mellitus pathogenesis. Amongst other hypotheses, it has been suggested that Mg2+ deficiency affects insulin secreti

Externí odkaz: https://doaj.org/article/90b8f5467ce0413fa566aa8533b52936

Generating Beta-Cell-Specific Transgenic Mice Using the Cre-Lox System

Autor: Lorna I F, Smith, Thomas G, Hill, James E, Bowe

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2128

Beta-cell-specific transgenic mice provide an invaluable model for dissecting the direct signaling mechanisms involved in regulating beta-cell structure and function. Furthermore, generating novel transgenic models is now easier and more cost-effecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ac5dbf30a1ef168ac5a8f80969a0faf
https://pubmed.ncbi.nlm.nih.gov/32180194

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

Autor: Patrik Rorsman, Martijn van de Bunt, Linford J.B. Briant, Jakob G. Knudsen, Joely A. Kellard, Sarah L. Armour, Nils J.G. Rorsman, Thomas G. Hill

Publikováno v: Kellard, J A, Rorsman, N J G, Hill, T G, Armour, S L, van de Bunt, M, Rorsman, P, Knudsen, J G & Briant, L J B 2020, ' Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet ', Molecular Metabolism, vol. 40, 101021 . https://doi.org/10.1016/j.molmet.2020.101021
Molecular Metabolism, Vol 40, Iss, Pp 101021-(2020)
Molecular Metabolism

Objectives Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD). Methods Female mice expressing the Ca2+ indic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c940e657d80c41fbb31501c12eb4a5
https://curis.ku.dk/ws/files/244277596/Reduced_somatostatin_signalling_leads_to_hypersecretion_of_glucagon_in_mice_fed_a_high_fat_diet.pdf