Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Thomas G, Bernhardt"'
Autor:
Erkin Kuru, Jonathan Rittichier, Helena de Puig, Allison Flores, Subhrajit Rout, Isaac Han, Abigail E. Reese, Thomas M. Bartlett, Fabio De Moliner, Sylvie G. Bernier, Jason D. Galpin, Jorge Marchand, William Bedell, Lindsey Robinson-McCarthy, Christopher A. Ahern, Thomas G. Bernhardt, David Z. Rudner, James J. Collins, Marc Vendrell, George M. Church
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Binding-activated optical sensors are powerful tools for imaging, diagnostics, and biomolecular sensing. However, biosensor discovery is slow and requires tedious steps in rational design, screening, and characterization. Here we report on a
Externí odkaz:
https://doaj.org/article/8c008f8b3019484da6521bb74160e592
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatm
Externí odkaz:
https://doaj.org/article/b64b6556dae14659a77ca1ac86b80b34
Autor:
Irina Shlosman, Elayne M. Fivenson, Morgan S. A. Gilman, Tyler A. Sisley, Suzanne Walker, Thomas G. Bernhardt, Andrew C. Kruse, Joseph J. Loparo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The peptidoglycan (PG) cell wall protects bacteria against osmotic lysis and determines cell shape, making this structure a key antibiotic target. Peptidoglycan is a polymer of glycan chains connected by peptide crosslinks, and its synthesis
Externí odkaz:
https://doaj.org/article/46f4aabe611d4823be2a46c4d4c0f829
Autor:
Caroline Midonet, Sean Bisset, Irina Shlosman, Felipe Cava, David Z. Rudner, Thomas G. Bernhardt
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTThe peptidoglycan (PG) layer protects bacteria from osmotic lysis and defines their shape. The class A penicillin-binding proteins (aPBPs) are PG synthases that possess both glycan polymerization and crosslinking activities needed for PG biog
Externí odkaz:
https://doaj.org/article/222ac13364d9434880980e4f3588664a
Publikováno v:
eLife, Vol 11 (2022)
Bacteria of the order Corynebacteriales including pathogens such as Mycobacterium tuberculosis and Corynebacterium diphtheriae are characterized by their complex, multi-layered envelope. In addition to a peptidoglycan layer, these organisms possess a
Externí odkaz:
https://doaj.org/article/b2291360cd5b48a5b7b84257251440f4
Publikováno v:
eLife, Vol 11 (2022)
Penicillin and related antibiotics disrupt cell wall synthesis in bacteria causing the downstream misactivation of cell wall hydrolases called autolysins to induce cell lysis. Despite the clinical importance of this phenomenon, little is known about
Externí odkaz:
https://doaj.org/article/d412878cee5f4f28bddce0886fd69eaa
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
The Corynebacterineae
Externí odkaz:
https://doaj.org/article/213ab4ab0dc145978f1c5730178607e5
Autor:
Katherine R. Hummels, Samuel P. Berry, Zhaoqi Li, Atsushi Taguchi, Joseph K. Min, Suzanne Walker, Debora S. Marks, Thomas G. Bernhardt
Publikováno v:
Nature. 615:300-304
Gram-negative bacteria surround their cytoplasmic membrane with a peptidoglycan (PG) cell wall and an outer membrane (OM) with an outer leaflet composed of lipopolysaccharide (LPS)1. This complex envelope presents a formidable barrier to drug entry a
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Gram-negative bacteria are surrounded by a complex cell envelope that includes two membranes. The outer membrane prevents many drugs from entering these cells and is thus a major determinant of their intrinsic antibiotic resistance. This bar
Externí odkaz:
https://doaj.org/article/44772145b1834a55a43fde23da62467f
Publikováno v:
eLife, Vol 9 (2020)
Members of the Corynebacterineae suborder of Actinobacteria have a unique cell surface architecture and, unlike most well-studied bacteria, grow by tip-extension. To investigate the distinct morphogenic mechanisms shared by these organisms, we perfor
Externí odkaz:
https://doaj.org/article/6279c6f82552406fb15eb30355933fca