Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Thomas Friedberg"'
Autor:
C. Roland Wolf, Alasdair Stenhouse, Thomas Friedberg, D. Grahame Hardie, Simon A. Hawley, Calum Sutherland, Franck Rencurel
Publikováno v:
Journal of Biological Chemistry. 280:4367-4373
Phenobarbital (PB) administration is known to trigger pleiotropic responses, including liver hypertrophy, tumor promotion, and induction of genes encoding drug-metabolizing enzymes. The induction of human CYP2B6 and the rat (CYP2B1) and mouse (Cyp2b1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1563eb2292cc0e570c9e15e763689f4c
https://doi.org/10.1074/jbc.m412711200
https://doi.org/10.1074/jbc.m412711200
Autor:
Clive J. Ward, Andy Ayrton, Lay-Beng Goh, Kevin J. Spears, C. Roland Wolf, Jillian Ross, Alasdair Stenhouse, Paul Morgan, Thomas Friedberg
Publikováno v:
Biochemical Pharmacology. 69:415-423
The transcellular transport of many compounds, which cannot readily cross the lipid bilayer, is mediated by drug uptake and efflux transporters. Human OATP1B1 and MRP2 have been implicated in the hepato-biliary transport of many endogenous and exogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598141dd588ab2bffd0576cd09bbf7e4
https://doi.org/10.1016/j.bcp.2004.09.026
https://doi.org/10.1016/j.bcp.2004.09.026
Autor:
Duncan I. Jodrell, Noam Zelcer, Denggao Yao, Jeffrey Cummings, John F. Allen, Mark Maliepaard, Gary Boyd, Thomas Friedberg, John F. Smyth
Publikováno v:
Biochemical pharmacology, 67(1), 31-39. Elsevier Inc.
We have recently shown that drug conjugation catalysed by UDP-glucuronosyltransferases (UGTs) functions as an intrinsic mechanism of resistance to the topoisomerase I inhibitors 7-ethyl-10-hydroxycamptothecin and NU/ICRF 505 in human colon cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca754f5a170e98842d0afdbde24a401
https://doi.org/10.1016/j.bcp.2003.07.019
https://doi.org/10.1016/j.bcp.2003.07.019
Publikováno v:
Pharmacology & Toxicology. 93:14-22
Recombinant cytochrome P450 (CYP) 1A2, 3A4, 2C9 or 2D6 enzymes obtained from Escherichia coli and human liver microsomes samples were used to investigate the ability of human CYP enzymes to metabolize the two dietary flavonoids, genistein and tangere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a12b9243d554d4649c41d93d8902abe
https://doi.org/10.1034/j.1600-0773.2003.930102.x
https://doi.org/10.1034/j.1600-0773.2003.930102.x
Publikováno v:
Biochemical Pharmacology. 65:1817-1826
We developed a biosensor based on the redox properties of human CYP3A4 to directly monitor electron transfer to the heme protein. Enzyme films were assembled on gold electrodes by alternate adsorption of a CYP3A4 layer on top of a polycation layer. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1711998749f6f0abe41ccf17b8a921ab
https://doi.org/10.1016/s0006-2952(03)00186-2
https://doi.org/10.1016/s0006-2952(03)00186-2
Publikováno v:
Pharmaceutical Research. 19:1034-1037
Purpose. This study was conducted to identify the cytochrome P450s (CYPs) responsible for the metabolism of the cis- and trans-isomers of the tricyclic antidepressant doxepin to its pharmacologically active N-desmethylmetabolite by in vitro technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7e70879eb47a8d4997d9d2d903ec69f
https://doi.org/10.1023/a:1016478708902
https://doi.org/10.1023/a:1016478708902
Publikováno v:
Biochemical Journal. 356:613-619
NADPH-P450 oxidoreductase (CPR) is essential for the activity of cytochrome P450 (P450). Previous studies demonstrated that CPR regulates the levels of various P450 isoforms in vitro. We investigated the mechanistic basis for this regulation. By tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081fce637fe034eec1548812b6b5b055
https://doi.org/10.1042/bj3560613
https://doi.org/10.1042/bj3560613
Autor:
Franz Oesch, Ximing Wang, Harald Weigmann, Michael Arand, Thomas Friedberg, Christoph Hiemke, Sebastian Härtter
Publikováno v:
ResearcherID
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Beca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9852eb906c33d4a922cae63eb8118368
https://doi.org/10.1097/00004714-200104000-00008
https://doi.org/10.1097/00004714-200104000-00008
Publikováno v:
Proceedings of the National Academy of Sciences. 98:81-86
A functional human NADH-dependent cytochrome P450 system has been developed by altering the cofactor preference of human NADPH cytochrome P450 reductase (CPR), the redox partner for P450s. This has been achieved by a single amino acid change of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1a170c2d5a0fdae48bf61a69379bfe
https://doi.org/10.1073/pnas.98.1.81
https://doi.org/10.1073/pnas.98.1.81
Publikováno v:
Pharmacogenetics. 10:343-353
Most drug metabolizing cytochrome P450s (P450) are predominantly expressed in the liver. In contrast, human CYP1B1 is an extrahepatic P450 which is overexpressed in many tumours and has been strongly implicated in the activation of carcinogens. Rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d598145eb8e7b2826b2b1208abb8cd0
https://doi.org/10.1097/00008571-200006000-00008
https://doi.org/10.1097/00008571-200006000-00008