Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Thomas Friedberg"'
Autor:
Franz Oesch, Roland Wolf
Publikováno v:
Archives of Toxicology. 83:959-960
Akademický článek
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Autor:
C. Roland Wolf, Alasdair Stenhouse, Thomas Friedberg, D. Grahame Hardie, Simon A. Hawley, Calum Sutherland, Franck Rencurel
Publikováno v:
Journal of Biological Chemistry. 280:4367-4373
Phenobarbital (PB) administration is known to trigger pleiotropic responses, including liver hypertrophy, tumor promotion, and induction of genes encoding drug-metabolizing enzymes. The induction of human CYP2B6 and the rat (CYP2B1) and mouse (Cyp2b1
Autor:
Duncan I. Jodrell, Noam Zelcer, Denggao Yao, Jeffrey Cummings, John F. Allen, Mark Maliepaard, Gary Boyd, Thomas Friedberg, John F. Smyth
Publikováno v:
Biochemical pharmacology, 67(1), 31-39. Elsevier Inc.
We have recently shown that drug conjugation catalysed by UDP-glucuronosyltransferases (UGTs) functions as an intrinsic mechanism of resistance to the topoisomerase I inhibitors 7-ethyl-10-hydroxycamptothecin and NU/ICRF 505 in human colon cancer cel
Publikováno v:
Pharmacology & Toxicology. 93:14-22
Recombinant cytochrome P450 (CYP) 1A2, 3A4, 2C9 or 2D6 enzymes obtained from Escherichia coli and human liver microsomes samples were used to investigate the ability of human CYP enzymes to metabolize the two dietary flavonoids, genistein and tangere
Publikováno v:
Biochemical Pharmacology. 65:1817-1826
We developed a biosensor based on the redox properties of human CYP3A4 to directly monitor electron transfer to the heme protein. Enzyme films were assembled on gold electrodes by alternate adsorption of a CYP3A4 layer on top of a polycation layer. D
Publikováno v:
Pharmaceutical Research. 19:1034-1037
Purpose. This study was conducted to identify the cytochrome P450s (CYPs) responsible for the metabolism of the cis- and trans-isomers of the tricyclic antidepressant doxepin to its pharmacologically active N-desmethylmetabolite by in vitro technique
Publikováno v:
Biochemical Journal. 356:613-619
NADPH-P450 oxidoreductase (CPR) is essential for the activity of cytochrome P450 (P450). Previous studies demonstrated that CPR regulates the levels of various P450 isoforms in vitro. We investigated the mechanistic basis for this regulation. By tran
Autor:
Franz Oesch, Ximing Wang, Harald Weigmann, Michael Arand, Thomas Friedberg, Christoph Hiemke, Sebastian Härtter
Publikováno v:
ResearcherID
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Beca
Publikováno v:
Proceedings of the National Academy of Sciences. 98:81-86
A functional human NADH-dependent cytochrome P450 system has been developed by altering the cofactor preference of human NADPH cytochrome P450 reductase (CPR), the redox partner for P450s. This has been achieved by a single amino acid change of the c