Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Thomas Falguières"'
Autor:
Mounia Lakli, Julie Dumont, Virginie Vauthier, Julie Charton, Veronica Crespi, Manon Banet, Yosra Riahi, Amel Ben Saad, Elodie Mareux, Martine Lapalus, Emmanuel Gonzales, Emmanuel Jacquemin, Florent Di Meo, Benoit Deprez, Florence Leroux, Thomas Falguières
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract ABCB4 is located at the canalicular membrane of hepatocytes and is responsible for the secretion of phosphatidylcholine into bile. Genetic variations of this transporter are correlated with rare cholestatic liver diseases, the most severe be
Externí odkaz:
https://doaj.org/article/15d3c2a95c39433cb086203c92b4dc08
Autor:
Emmanuel Gonzales, Antoine Gardin, Marion Almes, Amaria Darmellah-Remil, Hanh Seguin, Charlotte Mussini, Stéphanie Franchi-Abella, Mathieu Duché, Oanez Ackermann, Alice Thébaut, Dalila Habes, Bogdan Hermeziu, Martine Lapalus, Thomas Falguières, Jean-Philippe Combal, Bernard Benichou, Sonia Valero, Anne Davit-Spraul, Emmanuel Jacquemin
Publikováno v:
JHEP Reports, Vol 5, Iss 10, Pp 100844- (2023)
Background & Aims: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare liver disease caused by biallelic variations in ABCB4. Data reporting on the impact of genotype and of response to ursodeoxycholic acid (UDCA) therapy on long-t
Externí odkaz:
https://doaj.org/article/5e41a2b0590743f2ae9ca730fde774d7
Autor:
Elodie Mareux, Martine Lapalus, Amel Ben-Saad, Isabelle Callebaut, Thomas Falguières, Emmanuel Gonzales, Emmanuel Jacquemin
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-4 (2021)
Abstract Background ABCB11 variations are responsible for a spectrum of rare liver diseases, including progressive familial intrahepatic cholestasis type 2 (PFIC2) and intrahepatic cholestasis of pregnancy (ICP). Current medical treatment of these co
Externí odkaz:
https://doaj.org/article/2224e9e12283412f8afa4558224ab794
Autor:
Elodie Mareux, Martine Lapalus, Amel Ben Saad, Renaud Zelli, Mounia Lakli, Yosra Riahi, Marion Almes, Manon Banet, Isabelle Callebaut, Jean-Luc Decout, Thomas Falguières, Emmanuel Jacquemin, Emmanuel Gonzales
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10758 (2022)
ABCB11 is responsible for biliary bile acid secretion at the canalicular membrane of hepatocytes. Variations in the ABCB11 gene cause a spectrum of rare liver diseases. The most severe form is progressive familial intrahepatic cholestasis type 2 (PFI
Externí odkaz:
https://doaj.org/article/0873ff64b92c4ee2bf9d64c9d6d38491
Autor:
Thomas Falguières
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4250 (2022)
The goal of this Special Issue on “ABC Transporters in Human Diseases”, for which I was invited as a Guest Editor, was to provide an overview of the state-of-the-art research, understandings, and advances made in recent years on human diseases im
Externí odkaz:
https://doaj.org/article/ad89becb28db436090ca2c0b501624c9
Autor:
Alix Bruneau, Jean-Louis Delaunay, Anne-Marie Durand-Schneider, Virginie Vauthier, Amel Ben Saad, Lynda Aoudjehane, Haquima El Mourabit, Romain Morichon, Thomas Falguières, Jérémie Gautheron, Chantal Housset, Tounsia Aït-Slimane
Publikováno v:
Cells, Vol 11, Iss 4, p 617 (2022)
ABCB4, is an adenosine triphosphate-binding cassette (ABC) transporter localized at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine secretion into bile. Gene variations of ABCB4 cause different types of liver diseases,
Externí odkaz:
https://doaj.org/article/1d4ade379e9b40148174424e5d1942ed
Autor:
Julien Gautherot, Thierry Claudel, Frans Cuperus, Claudia Daniela Fuchs, Thomas Falguières, Michael Trauner
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1610-1619 (2018)
The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes. Defective ABCB4 gene expression and protein function result in various cholestatic liver and bile d
Externí odkaz:
https://doaj.org/article/37dfb46bfc834e1f8d738e0760345bb8
Autor:
Amel Ben Saad, Virginie Vauthier, Martine Lapalus, Elodie Mareux, Evangéline Bennana, Anne-Marie Durand-Schneider, Alix Bruneau, Jean-Louis Delaunay, Emmanuel Gonzales, Chantal Housset, Tounsia Aït-Slimane, François Guillonneau, Emmanuel Jacquemin, Thomas Falguières
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7087 (2021)
ABCB4 (ATP-binding cassette subfamily B member 4) is an ABC transporter expressed at the canalicular membrane of hepatocytes where it ensures phosphatidylcholine secretion into bile. Genetic variations of ABCB4 are associated with several rare choles
Externí odkaz:
https://doaj.org/article/9c3eebb2e6de408fb3ca9dfdcd01dc26
Autor:
Amel Ben Saad, Alix Bruneau, Elodie Mareux, Martine Lapalus, Jean-Louis Delaunay, Emmanuel Gonzales, Emmanuel Jacquemin, Tounsia Aït-Slimane, Thomas Falguières
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2113 (2021)
The ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of hepatocytes mediate the secretion of several compounds into the bile canaliculi and therefore play a key role in bile secretion. Among these transporters, ABCB11 sec
Externí odkaz:
https://doaj.org/article/efd9df82799e4b52a4fbbc93657728df
Autor:
Quitterie Venot, Jean-Louis Delaunay, Laura Fouassier, Danièle Delautier, Thomas Falguières, Chantal Housset, Michèle Maurice, Tounsia Aït-Slimane
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146962 (2016)
ABCB4/MDR3, a member of the ABC superfamily, is an ATP-dependent phosphatidylcholine translocator expressed at the canalicular membrane of hepatocytes. Defects in the ABCB4 gene are associated with rare biliary diseases. It is essential to understand
Externí odkaz:
https://doaj.org/article/08c70141a40d4fcbb9783efca6df7234