Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thomas F. Zioncheck"'
Autor:
Thomas F. Zioncheck, Wyne P. Leeè, Edward P. Amentoè, Yvette Xuè, Louise Richardson, Leo Deguzmanè, L. Steven Beckè
Publikováno v:
Journal of Bone and Mineral Research. 8:1407-1414
Bone healing is regulated in part by the local production of TGF-β1 and other growth factors produced by cells at the site of injury. The single application of recombinant human TGF-β1 (rhTGF-β1) to calvarial defects in rabbits induces an accelera
Autor:
Joseph Kohles, Yu-E Zhang, Ben-Quan Shen, Packman Kathryn E, Brian Higgins, David C. Heimbrook, Kenneth Kolinsky, Thomas F. Zioncheck, Ute Dugan
Publikováno v:
Molecular Cancer Therapeutics. 8:75-82
Modifying the capecitabine dosing schedule from 14 days on, 7 days off (14/7) to 7 days on, 7 days off (7/7) may enable higher doses and improved antitumor efficacy in colorectal cancer xenografts. Capecitabine 14/7 (267 or 400 mg/kg) and 7/7 (467 or
Publikováno v:
Journal of Cardiovascular Pharmacology. 44:615-621
The role of the vascular endothelial growth factors (VEGF) receptors (KDR and Flt-1) and their characteristics in VEGF-induced vasodilation in human vessels is unclear. This study investigated the in vitro vasorelaxant effects of KDR-selective (KDR-S
Autor:
Stephen Eppler, Stephen G. Ellis, Daniel L. Combs, Timothy D. Henry, Joo Hee Yi, Brian H. Annex, Edward R. McCluskey, John J. Lopez, Thomas F. Zioncheck
Publikováno v:
Clinical Pharmacology & Therapeutics. 72:20-32
Background The Vascular Endothelial Growth Factor (VEGF) in Ischemiafor Vascular Angiogenesis (VIVA) trial was a double-blind, placebo-controlled, phase II clinical trial designed to evaluate the safety, efficacy, and pharmacokinetics of combinedintr
Autor:
Nicolas Pelletier, Napoleone Ferrara, Bing Li, Barbara Moffat, Thomas F. Zioncheck, Hendrik Gille, Joe Kowalski, Jennifer LeCouter
Publikováno v:
Journal of Biological Chemistry. 276:3222-3230
Endothelial cells express two related vascular endothelial growth factor (VEGF) receptor tyrosine kinases, KDR (kinase-insert domain containing receptor, or VEGFR-2) and Flt-1 (fms-like tyrosine kinase, or VEGFR-1). Although considerable experimental
Publikováno v:
Journal of Biological Chemistry. 276:5281-5286
Vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-alpha) have been shown to synergistically increase tissue factor (TF) expression in endothelial cells; however, the role of the VEGF receptors (KDR, Flt-1, and neuropilin)
Autor:
David Y. Lee, Ben-Quan Shen, Napoleone Ferrara, Bruce Keyt, Hans-Peter Gerber, Thomas F. Zioncheck
Publikováno v:
Journal of Biological Chemistry. 273:29979-29985
We investigated the possibility that vascular endothelial growth factor (VEGF) treatment could regulate KDR/Flk-1 receptor expression in endothelial cells. Bovine adrenal cortex endothelial cells were incubated with 200 pM rhVEGF165 for 0-7 days. Wes
Autor:
Ralph H. Schwall, Thomas F. Zioncheck, Paul J. Godowski, David W. Kahn, Kenneth J. Hillan, Ling Y. Chang, Kenneth D. Bauer
Publikováno v:
The Journal of Cell Biology
Hepatocyte growth factor (HGF) is a potent epithelial mitogen whose actions are mediated through its receptor, the proto-oncogene c-Met. Two truncated variants of HGF known as NK1 and NK2 have been reported to be competitive inhibitors of HGF binding
Autor:
Kathleen L. King, Ralph H. Schwall, Ling Chang, Gregory L. Bennett, Steven M. Chamow, Peter Fugedi, Louise Richardson, Jun Liu, Thomas F. Zioncheck, Robert J. Stack
Publikováno v:
Journal of Biological Chemistry. 270:16871-16878
Hepatocyte growth factor (HGF) is a potent mitogen, motogen, and morphogen for various epithelial cell types. The pleiotropic effects of HGF are mediated by its binding to a specific high affinity receptor, c-Met. In addition, HGF binds to heparan su
Autor:
Stanley E. Hansen, L Richardson, Nishit B. Modi, Thomas F. Zioncheck, Geralyn G. DeGuzman, Paul J. Godowski
Publikováno v:
Endocrinology. 134:1879-1887
Hepatocyte growth factor (HGF) is a pluripotent mitogen thought to be involved in liver regeneration. It is synthesized as a single chain promitogen and requires proteolytic processing to a two-chain heterodimeric form for biological activity. The ph