Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Thomas F. Woolf"'
Autor:
Yifan Yang, Jürgen Borlak, Yu-Chuan Chen, Kan He, Jie Zhang, Lining Cai, Weigong Ge, Qin Shi, Lei Guo, Weida Tong, Thomas F. Woolf
Publikováno v:
Chemico-Biological Interactions. 255:45-54
Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of bile salts from their precursors in primary human,
Publikováno v:
Chemico-Biological Interactions. 255:23-30
The bile salt export pump protein (BSEP), expressed on the canalicular membranes of hepatocytes, is primarily responsible for the biliary excretion of bile salts. The inhibition of BSEP transport activity can lead to an increase in intracellular bile
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S96-S97
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S72
Publikováno v:
Chemical research in toxicology. 28(10)
MDR3 dysfunction is associated with liver diseases. We report here a novel MDR3 activity assay involving in situ biosynthesis in primary hepatocytes of deuterium (d9)-labeled PC and LC-MS/MS determination of transported extracellular PC-d9. Several d
Autor:
Alexander James Bridges, Rasmy Talaat, William F. Pool, Kan He, Michael D. Reily, Thomas F. Woolf, Jessica Elizabeth Reed
Publikováno v:
Drug Metabolism and Disposition. 32:639-646
Troglitazone (TGZ), the first glitazone used for the treatment of type II diabetes mellitus and removed from the market for liver toxicity, was shown to bind covalently to microsomal protein and glutathione (GSH) following activation by cytochrome P4
Autor:
Thomas F. Woolf, James D. Adams
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Several strategies are currently being explored for the development of agents to be used in stroke. Agents that inhibit necrotic mechanisms leading to infarction are especially sought. Drugs that enhance DNA repair, inhibit poly(ADP-ribose) polymeras
Publikováno v:
Chemical Research in Toxicology. 11:252-259
Grapefruit juice has been found to significantly increase oral bioavailability of several drugs metabolized by cytochrome P450 3A4 (P450 3A4) through inhibiting the enzymatic activity and decreasing the content of intestinal P450 3A4. HPLC/MS/MS and
Publikováno v:
Biochemical Pharmacology. 46:13-20
Tacrine (1,2,3,4-tetrahydro-9-aminoacridine hydrochloride; THA) is known to undergo extensive oxidative metabolism to a variety of mono- and dihydroxylated metabolites in animals and humans. The potential for tacrine to undergo metabolism to stable,
Autor:
Michael D. Reily, Susan M. Bjorge, Tsun Chang, Charles Taylor, Howard N. Bockbrader, Thomas F. Woolf, Louis L. Radulovic
Publikováno v:
Chemical Research in Toxicology. 6:341-344
Single-dose administration of 50 mg of 1-[2-[bis[4- (trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro-3- pyridinecarboxylic acid monohydrochloride resulted in temporary neurological and psychological symptoms in two subjects. Because of the n