Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Thomas F. Westbrook"'
Autor:
Habib Bouguenina, Stephanos Nicolaou, Yann-Vaï Le Bihan, Elizabeth A. Bowling, Cheyenne Calderon, John J. Caldwell, Brinley Harrington, Angela Hayes, P. Craig McAndrew, Costas Mitsopoulos, Fernando Jr. Sialana, Andrea Scarpino, Mark Stubbs, Arjun Thapaliya, Siddhartha Tyagi, Hannah Z. Wang, Francesca Wood, Rosemary Burke, Florence Raynaud, Jyoti Choudhary, Rob L.M. van Montfort, Amine Sadok, Thomas F. Westbrook, Ian Collins, Rajesh Chopra
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107059- (2023)
Summary: To address the limitation associated with degron based systems, we have developed iTAG, a synthetic tag based on IMiDs/CELMoDs mechanism of action that improves and addresses the limitations of both PROTAC and previous IMiDs/CeLMoDs based ta
Externí odkaz:
https://doaj.org/article/deed144041474c6d99c938d0c74b984d
Autor:
Alison Hirukawa, Salendra Singh, Jarey Wang, Jonathan P. Rennhack, Matthew Swiatnicki, Virginie Sanguin-Gendreau, Dongmei Zuo, Kamilia Daldoul, Cynthia Lavoie, Morag Park, Eran R. Andrechek, Thomas F. Westbrook, Lyndsay N. Harris, Vinay Varadan, Harvey W. Smith, William J. Muller
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 249-257.e8 (2019)
Summary: Monoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proporti
Externí odkaz:
https://doaj.org/article/d72321d9dd27483ea95dfcd6db827f5b
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression
Autor:
Cody T. Mowery, Jaime M. Reyes, Lucia Cabal-Hierro, Kelly J. Higby, Kristen L. Karlin, Jarey H. Wang, Robert J. Kimmerling, Paloma Cejas, Klothilda Lim, Hubo Li, Takashi Furusawa, Henry W. Long, David Pellman, Bjoern Chapuy, Michael Bustin, Scott R. Manalis, Thomas F. Westbrook, Charles Y. Lin, Andrew A. Lane
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1898-1911.e5 (2018)
Summary: Down syndrome (DS, trisomy 21) is associated with developmental abnormalities and increased leukemia risk. To reconcile chromatin alterations with transcriptome changes, we performed paired exogenous spike-in normalized RNA and chromatin imm
Externí odkaz:
https://doaj.org/article/70783644fe2f43be951838ad8302663a
Autor:
Lior Izhar, Britt Adamson, Alberto Ciccia, Jedd Lewis, Laura Pontano-Vaites, Yumei Leng, Anthony C. Liang, Thomas F. Westbrook, J. Wade Harper, Stephen J. Elledge
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1486-1500 (2015)
Localization to sites of DNA damage is a hallmark of DNA damage response (DDR) proteins. To identify DDR factors, we screened epitope-tagged proteins for localization to sites of chromatin damaged by UV laser microirradiation and found >120 proteins
Externí odkaz:
https://doaj.org/article/1e266c5645c54457ba46da3fda7395d2
Autor:
Kristen L. Karlin, Gourish Mondal, Jessica K. Hartman, Siddhartha Tyagi, Sarah J. Kurley, Chris S. Bland, Tiffany Y.T. Hsu, Alexander Renwick, Justin E. Fang, Ilenia Migliaccio, Celetta Callaway, Amritha Nair, Rocio Dominguez-Vidana, Don X. Nguyen, C. Kent Osborne, Rachel Schiff, Li-Yuan Yu-Lee, Sung Y. Jung, Dean P. Edwards, Susan G. Hilsenbeck, Jeffrey M. Rosen, Xiang H.-F. Zhang, Chad A. Shaw, Fergus J. Couch, Thomas F. Westbrook
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1318-1332 (2014)
Defining the molecular networks that drive breast cancer has led to therapeutic interventions and improved patient survival. However, the aggressive triple-negative breast cancer subtype (TNBC) remains recalcitrant to targeted therapies because its m
Externí odkaz:
https://doaj.org/article/f1e3e5e6d0304dd2bb7aabf105868310
Autor:
Bhuvanesh Dave, Melissa D. Landis, Lacey E. Dobrolecki, Meng-Fen Wu, Xiaomei Zhang, Thomas F. Westbrook, Susan G. Hilsenbeck, Dan Liu, Michael T. Lewis, David J. Tweardy, Jenny C. Chang
Publikováno v:
PLoS ONE, Vol 7, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/7a6c65afc0ae4cb397a3bc3ab093a1c6
Autor:
Wesley L Cai, Jocelyn Fang-Yi Chen, Huacui Chen, Emily Wingrove, Sarah J Kurley, Lok Hei Chan, Meiling Zhang, Anna Arnal-Estape, Minghui Zhao, Amer Balabaki, Wenxue Li, Xufen Yu, Ethan D Krop, Yali Dou, Yansheng Liu, Jian Jin, Thomas F Westbrook, Don X Nguyen, Qin Yan
Publikováno v:
eLife, Vol 11 (2022)
Metastatic breast cancer remains a major cause of cancer-related deaths in women, and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor progression and metastasis are controlled by rev
Externí odkaz:
https://doaj.org/article/58606a0ba92e4cb2b78d6211456a60e4
Autor:
Raghav Ramabadran, Jarey H. Wang, Jaime M. Reyes, Anna G. Guzman, Sinjini Gupta, Carina Rosas, Lorenzo Brunetti, Michael C. Gundry, Ayala Tovy, Hali Long, Tianpeng Gu, Sean M. Cullen, Siddhartha Tyagi, Danielle Rux, Jean J. Kim, Steven M. Kornblau, Michael Kyba, Fabio Stossi, Rachel E. Rau, Koichi Takahashi, Thomas F. Westbrook, Margaret A. Goodell
Publikováno v:
Nature Cell Biology. 25:528-539
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
93 gene signature that characterizes ZFTA-Rela mouse and human tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2455a45bb7a7160f6ff2e0c7dedb37da
https://doi.org/10.1158/2159-8290.22539655.v1
https://doi.org/10.1158/2159-8290.22539655.v1
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
Figure S2 supporting expression and localization of ZRfus in the mouse IUE model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5100705dc6a0f49c6241a385bfa4fe37
https://doi.org/10.1158/2159-8290.22539676
https://doi.org/10.1158/2159-8290.22539676