Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Thomas F. Walsh"'
Autor:
Julie A. DeMartino, James A. Milligan, Edward C. Sherer, Thomas F. Walsh, Richard Hajdu, Russell B. Lingham, Xinchun Tong, Michael Wolff, Denise M. Visco, Mikhail Reibarkh, Matthew J. Clements, Jeffrey T. Kuethe, Randy R. Miller, Christina B. Madsen-Duggan, Lisa M. Sonatore, Scott P. Salowe, Dominique Stickens, Jianmei Pang, Jeffrey J. Hale, Dan Zhou, John S. Debenham
Publikováno v:
Journal of medicinal chemistry. 59(24)
The discovery of novel 4-hydroxy-2-(heterocyclic)pyrimidine-5-carboxamide inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) is described. These are potent, selective, orally bioavailable across several species, and active in stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d6d174fbd4111c1eb7c610defd4bfd
https://pubmed.ncbi.nlm.nih.gov/28002958
https://pubmed.ncbi.nlm.nih.gov/28002958
Autor:
Timothy M. Morgan, Eric L. Wallace, Thomas F. Walsh, Craig A. Hamilton, W. Gregory Hundley, Erica Dall'Armellina, William O. Ntim
OBJECTIVES: The purpose of this study was to determine the prognostic utility of dobutamine cardiac magnetic resonance (DCMR) stress test results in women. BACKGROUND: To date, the preponderance of studies reporting the utility of DCMR stress results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cda9792259e1db5fad91a5268e8fd8
https://doi.org/10.1016/j.jcmg.2008.10.015
https://doi.org/10.1016/j.jcmg.2008.10.015
Autor:
Alison M. Strack, Xinchun Tong, Christina B. Madsen-Duggan, Lauren P. Shearman, Cathy R.-R.C. Huang, Mark T. Goulet, Thomas F. Walsh, Yue Feng, Jing Chen Xiao, D. Sloan Stribling, Junying Wang, John S. Debenham, Tung M. Fong, Chun-Pyn Shen, Sanjeev Kumar, Julie Lao, Donald J. Marsh, Richard B. Toupence
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1448-1452
The synthesis, SAR and binding affinities of cannabinoid-1 receptor (CB1R) inverse agonists based on furo[2,3-b]pyridine scaffolds are described. Food intake, mechanism specific efficacy, pharmacokinetic, and metabolic evaluation of several of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1532b90f262f2aeb80999245ecf0e113
https://doi.org/10.1016/j.bmcl.2009.12.065
https://doi.org/10.1016/j.bmcl.2009.12.065
Autor:
Junying Wang, Jing Chen Xiao, D. Sloan Stribling, Marie-Therese Schaeffer, Alison M. Strack, Lauren P. Shearman, Cathy C. R.-R. Huang, D. Euan MacIntyre, Thomas F. Walsh, Christina B. Madsen-Duggan, Chun-Pyn Shen, John S. Debenham, Jeffrey J. Hale, Tung M. Fong, Julie Lao, Xinchun Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2591-2594
The synthesis, SAR and binding affinities are described for cannabinoid-1 receptor (CB1R) specific inverse agonists based on pyridopyrimidine and heterotricyclic scaffolds. Food intake and pharmacokinetic evaluation of several of these compounds indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a2f9d84b2ab0be0bec0ac56bc26960
https://doi.org/10.1016/j.bmcl.2009.03.005
https://doi.org/10.1016/j.bmcl.2009.03.005
Publikováno v:
Nutrition, Metabolism and Cardiovascular Diseases. 18:283-290
Background and aims Whole grain food sources have been associated with lowered risk of cardiovascular disease (CVD). Studies in recent years have strengthened this observation and elucidated potential mechanisms for this association. This study sough
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe0e67bf63fd02eec02392c47a58cbb
https://doi.org/10.1016/j.numecd.2006.12.008
https://doi.org/10.1016/j.numecd.2006.12.008
Autor:
Mark T. Goulet, Christina B. Madsen-Duggan, Yue Feng, George A. Doss, Jing Chen Xiao, John S. Debenham, Cathy R.-R.C. Huang, Lex H.T. Van der Ploeg, Alison M. Strack, Chun-Pyn Shen, Marie-Therese Schaeffer, Donald J. Marsh, Junying Wang, D. Euan MacIntyre, Julie Lao, Tung M. Fong, D. Sloan Stribling, Lauren P. Shearman, Thomas F. Walsh, Xinchun Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:681-685
Synthesis, SAR, and binding affinities are described for a new class of 1,8-naphthyridinone CB1 receptor specific inverse agonists. Food intake, knockout mouse, and pharmacokinetic evaluation of 14 indicate that this compound is an effective orally a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37afeaeaf562672568ac44a526b40c47
https://doi.org/10.1016/j.bmcl.2005.10.028
https://doi.org/10.1016/j.bmcl.2005.10.028
Autor:
Christine Snedden, Mark T. Goulet, Tanya MacNeil, Matthew J. Wyvratt, David H. Weinberg, Thomas F. Walsh, Warner Daniel, Lex H.T. Van der Ploeg, Ricky D. Grisson, Rubana N. Kalyani, Rui Tang, Feroze Ujjainwalla
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4023-4028
Optimization of the biological activity of a new class of non-peptidyl, pyridazinone derived human melanocortin subtype-4 receptor agonists is disclosed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af90622c89aedce7ac080dca61739711
https://doi.org/10.1016/j.bmcl.2005.06.033
https://doi.org/10.1016/j.bmcl.2005.06.033
Autor:
Mark T. Goulet, Kang Cheng, Ning Ren, Robert J. DeVita, Jinlong Jiang, Matthew J. Wyvratt, Thomas F. Walsh, Jisong Cui, Jane L. Lo, Jason A. Fair, Jonathan R. Young, Yi T. Yang, Susan P. Rohrer, Mamta Parikh, Joel B. Yudkovitz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5599-5603
A series of neutral, nonbasic quinolone GnRH antagonists were prepared via Mitsunobu alkylation of protected and unprotected 4-hydroxy quinolone intermediates. The synthetic route was improved by utilization of unique reactivity and convergency affor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb2abe957eb46554b9f733c8235907d
https://doi.org/10.1016/j.bmcl.2004.08.056
https://doi.org/10.1016/j.bmcl.2004.08.056
Autor:
Mark T. Goulet, Lihu Yang, Aurawan Vongs, David H. Weinberg, Charles Rosenblum, Changyou Zhou, Feroze Ujjainwalla, Thomas F. Walsh, Matthew J. Wyvratt, Tanya MacNeil, Rubana N. Kalyani, Rui Tang, Lex H.T. Van der Ploeg, Warner Daniel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4431-4435
The discovery and optimization of a new class of non-peptidyl, pyridazinone derived melanocortin subtype-4 receptor agonists is disclosed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d2c34bd9e7e724008bb422d642c2fd
https://doi.org/10.1016/j.bmcl.2003.09.026
https://doi.org/10.1016/j.bmcl.2003.09.026
Autor:
Feroze Ujjainwalla, Thomas F. Walsh
Publikováno v:
Tetrahedron Letters. 42:6441-6445
The palladium(0)-catalyzed heteroannulation of a triethylsilyl alkyne and an ortho -aminoiodopyridine derivative is used as the key step in a highly convergent route to 6- and 7-azaindoles of biological interest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334ad1342acd305e0996ca19e1178d67
https://doi.org/10.1016/s0040-4039(01)01322-3
https://doi.org/10.1016/s0040-4039(01)01322-3