Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Thomas F. Schuessler"'
Mechanical consequences of allergic induced remodeling on mice airway resistance and compressibility
Autor:
Annette Robichaud, James G. Martin, Mauro Novali, Toby K. McGovern, Karim H. Shalaby, Thomas F. Schuessler, Andrea Benedetti, Liah Fereydoonzad
Publikováno v:
Respiratory Physiology & Neurobiology. 218:11-20
The effect of remodeling on airway function is uncertain. It may affect airway compressibility during forced expirations differently than airflow resistance, providing a tool for its assessment. The aim of the current study was to compare the effects
Autor:
Eric Troncy, Simon Authier, Thomas F. Schuessler, Alexis Ascah, Mylene Pouliot, Leanne Bassett, Annette Robichaud
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 70:283-286
Introduction A number of drugs in clinical trials are discontinued due to potentially life-threatening airway obstruction. As some drugs may not cause changes in core battery parameters such as tidal volume (V t ), respiratory rate (RR) or minute ven
Autor:
Thomas F. Schuessler, Geoffrey Truchetti, Leslie G. Gold, Annette Robichaud, Eric Troncy, Simon Authier, Leanne Bassett, Said Maghezzi
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 70:48-54
Introduction When the no observed adverse effect level (NOAEL) is determined by respiratory safety pharmacology, follow-up studies are warranted and may include airway resistance and compliance. Respiratory mechanics in commonly used large animal spe
Autor:
Leanne Bassett, Eric Troncy, Annette Robichaud, Thomas F. Schuessler, Mylène Pouliot, Alexis Ascah, Simon Authier
Publikováno v:
Journal of pharmacological and toxicological methods. 70(1)
A number of drugs in clinical trials are discontinued due to potentially life-threatening airway obstruction. As some drugs may not cause changes in core battery parameters such as tidal volume (Vt), respiratory rate (RR) or minute ventilation (MV),
Autor:
Robert E. Kearney, Peter Goldberg, Jason H. T. Bates, Thomas F. Schuessler, Stewart B. Gottfried
Publikováno v:
Annals of Biomedical Engineering. 26:260-267
Measurements of pressure swings in the esophagus (Pes can be used to estimate variables of clinical importance, e.g., intrinsic positive end-expiratory pressure (PEEPi. Unfortunately, cardiogenic oscillations frequently corrupt Pes and complicate fur
Autor:
Annette Robichaud, James G. Martin, Thomas F. Schuessler, Toby K. McGovern, Liah Fereydoonzad
Publikováno v:
Journal of Visualized Experiments.
The forced oscillation technique (FOT) is a powerful, integrative and translational tool permitting the experimental assessment of lung function in mice in a comprehensive, detailed, precise and reproducible manner. It provides measurements of respir
Publikováno v:
IEEE Transactions on Biomedical Engineering. 42:860-866
The understanding of the mechanical properties of the mammalian respiratory system and how they change under the influence of drugs and in disease are frequently pursued in small animals, since they can be easily obtained in large numbers as pure-bre
Publikováno v:
D30. NOVEL APPROACHES TO ASSESSING LUNG PATHOPHYSIOLOGY.
Autor:
Karim H. Shalaby, Liah Fereydoonzad, Thomas F. Schuessler, Mauro Novali, James G. Martin, Toby Mc Govern, Annette Robichaud
Publikováno v:
A97. MODELING REMODELING: HOW DISEASE AFFECTS THE AIRWAYS.
Publikováno v:
C110. COUGH AND AIRWAY RESPONSIVENESS: CO-MORBIDITIES.