Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thomas F. Schaible"'
Autor:
Thomas F Schaible
Publikováno v:
Canadian Journal of Gastroenterology, Vol 14, Iss Suppl C, Pp 29C-32C (2000)
Infliximab is a chimeric anti-tumour necrosis factor-alpha monoclonal antibody that has been studied for the treatment of Crohn’s disease and rheumatoid arthritis. In several placebo controlled, randomized clinical trials and open trials, 771 patie
Externí odkaz:
https://doaj.org/article/24dbb728f9b249439b32f868e70e8a76
Autor:
Josef S Smolen, Burkhard F. Leeb, Thomas F. Schaible, Ravinder N. Maini, Ferdinand C. Breedveld, C Antoni, M J Elliott, Marc Feldmann, Joachim R. Kalden, James N. Woody, Diana Davis, John D. Macfarlane
OBJECTIVE: To evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of multiple infusions of a chimeric monoclonal anti-tumor necrosis factor alpha antibody (cA2) (infliximab; Remicade, Centocor, Malvern, PA) given alone or in combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1e91ab0dbab56470fe0c95b3dd9941
https://ora.ox.ac.uk/objects/uuid:b6cd2920-1f1e-459a-a290-55e23d9d26e6
https://ora.ox.ac.uk/objects/uuid:b6cd2920-1f1e-459a-a290-55e23d9d26e6
Autor:
Hanns-Martin Lorenz, Joachim R. Kalden, Jürgen Schölmerich, Thomas F. Schaible, Rainer H. Straub, C Antoni, Georg Pongratz, Frieder Kees
Publikováno v:
Arthritis & Rheumatism. 48:1504-1512
Objective New insights into the role of tumor necrosis factor (TNF) in the pathogenesis of rheumatoid arthritis (RA) have expanded our understanding about the possible mechanisms by which anti-TNF antibody therapy reduces local synovial inflammation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::977dd3d70f0ce66dc31bab60817e2c79
https://doi.org/10.1002/art.11036
https://doi.org/10.1002/art.11036
Autor:
D. Shealy, G. D'Haens, S. R. Targan, C. Wagner, K. Geboes, Freddy Cornillie, S. E. Plevy, G. Van Assche, Paul Rutgeerts, Thomas F. Schaible, Jan Ceuppens
Publikováno v:
Alimentary Pharmacology & Therapeutics. 15:463-473
Background: Anti-TNFα therapy with infliximab is effective for Crohn’s disease. Infliximab neutralizes the biological activities of TNFα, a cytokine involved in host-defence against certain infections. Aim: To evaluate the effects of infliximab o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b5aea8adb2fb56cfa90976cec5f84a1
https://doi.org/10.1046/j.1365-2036.2001.00956.x
https://doi.org/10.1046/j.1365-2036.2001.00956.x
Publikováno v:
Annals of the Rheumatic Diseases. 58:i61-i64
Cytokines play a central part in the human immune response and can generally be categorised as proinflammatory or anti-inflammatory cytokines in nature. Tumour necrosis factor α (TNFα) is a proinflammatory cytokine and is a key mediator of inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae03b336c7a4f9fe770a1ae3021032f6
https://doi.org/10.1136/ard.58.2008.i61
https://doi.org/10.1136/ard.58.2008.i61
Publikováno v:
Seminars in Nuclear Medicine. 23:133-147
The remarkable progress in immunologic techniques in the development of monoclonal antibodies offers the potential for powerful new tools for the detection of cardiovascular disorders, such as acute myocardial necrosis and acute deep venous thrombosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7222e6d177052cf14fd70e51f9d9c0d4
https://doi.org/10.1016/s0001-2998(05)80094-7
https://doi.org/10.1016/s0001-2998(05)80094-7
Publikováno v:
Circulation. 85:298-304
BACKGROUND The T2G1s monoclonal antifibrin antibody binds specifically to fibrin but not to fibrinogen. METHODS AND RESULTS In a canine model of acute arterial thrombosis, we determined the feasibility of imaging thrombi using a 99mTc-labeled Fab' fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::933995fe9d137e3abcbc7c715828a351
https://doi.org/10.1161/01.cir.85.1.298
https://doi.org/10.1161/01.cir.85.1.298
Autor:
Abass Alavi, Thomas F. Schaible
Publikováno v:
Seminars in Nuclear Medicine. 21:313-324
Antifibrin scintigraphy is a new and innovative approach to the diagnosis of acute deep venous thrombosis (DVT). Many antifibrin monoclonal antibodies (Mo-Abs) have been described, but only two, 59D8 and T2G1s, have undergone broad preclinical or cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233702e06b98800cfaa67bc3881789d6
https://doi.org/10.1016/s0001-2998(05)80134-5
https://doi.org/10.1016/s0001-2998(05)80134-5
Autor:
Eric J. Topol, Bertram Pitt, Harlan F. Weisman, Thomas F. Schaible, Eric R. Bates, Stephen G. Ellis
Publikováno v:
Journal of the American College of Cardiology. 17:89-95
Despite many advances since its inception in humans in 1977, coronary angioplasty continues to be limited by the problems of abrupt arterial closure and late restenosis. Excessive platelet deposition at the site of angioplasty undoubtedly plays an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c6ae5f4459bffa6ac70eb518e4e688
https://doi.org/10.1016/0735-1097(91)90943-4
https://doi.org/10.1016/0735-1097(91)90943-4
Autor:
Rainer H, Straub, Georg, Pongratz, Jürgen, Schölmerich, Frieder, Kees, Thomas F, Schaible, Christian, Antoni, Joachim R, Kalden, Hanns-Martin, Lorenz
Publikováno v:
Arthritis and rheumatism. 48(6)
New insights into the role of tumor necrosis factor (TNF) in the pathogenesis of rheumatoid arthritis (RA) have expanded our understanding about the possible mechanisms by which anti-TNF antibody therapy reduces local synovial inflammation. Beyond lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de136c09c6395c9403daac003a80e3d4
https://pubmed.ncbi.nlm.nih.gov/12794817
https://pubmed.ncbi.nlm.nih.gov/12794817