Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Thomas F. Rau"'
Autor:
Zoe I. Day, Alyce J. Mayfosh, Amy A. Baxter, Scott A. Williams, Joanne M. Hildebrand, Thomas F. Rau, Ivan K. H. Poon, Mark D. Hulett
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 555 (2024)
Here, we describe GS-9, a novel water-soluble fatty acid-based formulation comprising L-lysine and arachidonic acid, that we have shown to induce ferroptosis. GS-9 forms vesicle-like structures in solution and mediates lipid peroxidation, as evidence
Externí odkaz:
https://doaj.org/article/7ae74655cf7a41208939f28a5aa2a6ea
Autor:
Zoe I. Day, Alyce J. Mayfosh, Marie-Claire Giel, Yuning Hong, Scott A. Williams, Jascinta P. Santavanond, Thomas F. Rau, Ivan K. Poon, Mark D. Hulett
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14170 (2022)
Undecylenic acid, a monounsaturated fatty acid, is currently in clinical use as a topical antifungal agent, however the potential for therapeutic application in other disease settings has not been investigated. In this study, we describe a novel plat
Externí odkaz:
https://doaj.org/article/26a3a85fa623410b8aef5f8112eb6a1c
Autor:
Alyce J. Mayfosh, Zoe I. Day, Nathan B. Unsworth, Chun-Qiang Liu, Ruchi Gupta, Soraya Haynes, Rebecca Abraham, Sam Abraham, Zo L. Shaw, Sumeet Walia, Aaron Elbourne, Mark D. Hulett, Thomas F. Rau
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1293 (2022)
The environmental control of microbial pathogens currently relies on compounds that do not exert long-lasting activity on surfaces, are impaired by soil, and contribute to the growing problem of antimicrobial resistance. This study presents the scien
Externí odkaz:
https://doaj.org/article/dd3f8d3a87cf4675902a2eb91ef28c37
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 1402-1417 (2014)
Phenoxybenzamine (PBZ) is an FDA approved α-1 adrenergic receptor antagonist that is currently used to treat symptoms of pheochromocytoma. However, it has not been studied as a neuroprotective agent for traumatic brain injury (TBI). While screening
Externí odkaz:
https://doaj.org/article/31f01c5b9f3e4f59a116e427b4846914
Autor:
Thomas F. Rau, Debbie Smith, Austin Poulsen, David Poulsen, Ziven MacWilliams, William Kelly, David A. Patterson
Publikováno v:
Epilepsy Research. 147:87-94
The rat lateral fluid-percussion injury (FPI) model has been used extensively to study post-traumatic epilepsy (PTE). Epidemiological studies have reported that the risk of PTE is higher after more severe injury. Adult, male Wistar rats subjected to
Autor:
Prasanthan Thaveenthiran, James H. Brennan, Edmond Sorich, Nanda Surendran, Jeffrey V. Rosenfeld, Mark Fitzgerald, Biswadev Mitra, Thomas F. Rau, Sarjubhai A. Patel
Publikováno v:
Journal of Clinical Neuroscience. 38:37-42
Prediction of post-concussive syndrome after apparent mild traumatic brain injury (TBI) and subsequent cognitive recovery remains challenging, with substantial limitations of current methods of cognitive testing. This pilot study aimed to determine i
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 64:231-236
Methamphetamine is a psychostimulant that was initially synthesized in 1920. Since then it has been used to treat attention deficit hyperactive disorder (ADHD), obesity and narcolepsy. However, methamphetamine has also become a major drug of abuse wo
Publikováno v:
Concussion
Aim: A small but notable number of individuals who suffer a concussion report ongoing cognitive difficulties. This preliminary study investigated the efficacy of repetitive test application to discern cognitive impairment in those with ongoing sympto
Publikováno v:
Modern Research in Inflammation. :9-23
We have previously demonstrated that acute treatment with low dose methamphetamine is neuroprotectivein a rat model of severe traumatic brain injury (TBI). Using gene expression analysis, we further showed that methamphetamine treatment significantly
Autor:
Diane M. Brooks, Sarjubhai A. Patel, Eric D. Wohlgehagen, Erin O. Semmens, Edmond Sorich, Thomas F. Rau, Alan J. Pearce
Publikováno v:
Experimental neurology. 297
Multiple mild traumatic brain injury (mmTBI), in certain cases, produces persistent symptoms. However, the molecular mechanisms underlying these symptoms remain unclear. Here, we demonstrate extended pathological changes in the rat brain following mm