Výsledky vyhledávání - "Thomas F. Parsons"

Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1

Autor: Yun Kenneth Kang, Paul J. Maddon, Robert J. Durso, James M. Binley, Antu K. Dey, Sai Prasad N. Iyer, Michael Franti, Thomas F Parsons, Gerald P. Donovan, Emma T. Crooks, Kenneth H. Roux, Ping Zhu, John P. Moore, Sofija Andjelic, William C. Olson

Publikováno v: Vaccine. 27:5120-5132

SOSIP gp140 trimers represent a soluble, stabilized, proteolytically cleaved form of the HIV-1 envelope (Env) glycoproteins. SOSIP gp140 derived from a subtype A HIV-1 isolate, KNH1144, forms exceptionally stable trimers that resemble virion-associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b46f08fa3d6d9083e6e4003c0fa7708
https://doi.org/10.1016/j.vaccine.2009.06.037

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Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop

Autor: Bruce Jaffee, Ping Li, Anlai Wang, Yajun Xu, Terri Addona, Zhi Li, Timothy D. Ocain, Hong Cheng, Hasmik Keshishian, Thomas F. Parsons, Chafen Lu, Marion Dorsch, Erik Dahlstrand

Publikováno v: Biochemical and Biophysical Research Communications. 352:609-616

Interleukin-1 stimulation leads to the recruitment of MyD88, interleukin-1 receptor-associated kinase 1 (IRAK-1) and interleukin-1 receptor-associated kinase 4 (IRAK-4) to the IL-1 receptor. The formation of the IL-1 receptor complex triggers a serie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793b267f9ab3585051d7b6197d7ae84a
https://doi.org/10.1016/j.bbrc.2006.11.068

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Configuration of a Scintillation Proximity Assay for the Activity Assessment of Recombinant Human Adenine Phosphoribosyltransferase

Autor: Michael E. Bembenek, Ping Li, Jennifer Alley, Heidi Spurling, Thomas F. Parsons, William D. Mallender, Jacqueline C. Pulido, Cynthia Barrett

Publikováno v: ASSAY and Drug Development Technologies. 4:661-669

Adenine phosphoribosyltransferase plays a role in purine salvage by catalyzing the direct conversion of adenine to adenosine monophosphate. The involvement of the purine salvage pathway in tumor proliferation and angiogenesis makes adenine phosphorib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fc5aac54ccf01e95f0be0741ef04c1
https://doi.org/10.1089/adt.2006.4.661

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Mycobacterium tuberculosis prcBAgenes encode a gated proteasome with broad oligopeptide specificity

Autor: Yune Z. Kunes, Nadine S. Weich, Ping Li, Zhiqiang Chen, Huilin Li, Gang Lin, Lawrence Dick, Peter Zwickl, Thomas F. Parsons, Christopher Tsu, Carl Nathan, Guiqing Hu

Publikováno v: Molecular Microbiology. 59:1405-1416

Genes predicted to be associated with the putative proteasome of Mycobacterium tuberculosis (Mtb) play a critical role in defence of the bacillus against nitrosative stress. However, proteasomes are uncommon in eubacteria and it remains to be establi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::888bb5c992a398b5a3e92c2011904238
https://doi.org/10.1111/j.1365-2958.2005.05035.x

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A Fluorescence-Based Coupling Reaction for Monitoring the Activity of Recombinant Human NAD Synthetase

Autor: Michael E. Bembenek, Lester Pullen, Eric Kuhn, Ping Li, William D. Mallender, Thomas F. Parsons

Publikováno v: ASSAY and Drug Development Technologies. 3:533-541

NAD synthetase is responsible for the conversion of nicotinic acid adenine dinucleotide to nicotinamide adenine dinucleotide. This reaction provides a biosynthetic route of the coenzyme and, thus, a source of cellular reducing equivalents. Alteration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bd03d7a0735f347993cb7a1c0dd563
https://doi.org/10.1089/adt.2005.3.533

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ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

Autor: Dominic Ryan, David Williams, Paul Towler, Jin Tang, Natalie A. Dales, Martin Fisher, Sridhar Prasad, Thomas F. Parsons, Saurabh Menon, Michael W. Pantoliano, Michael A. Patane, Bart L. Staker

Publikováno v: The Journal of Biological Chemistry

The angiotensin-converting enzyme (ACE)-related carboxypeptidase, ACE2, is a type I integral membrane protein of 805 amino acids that contains one HEXXH + E zinc-binding consensus sequence. ACE2 has been implicated in the regulation of heart function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba95732e63f969868aa8d11d43b7946d
https://doi.org/10.1074/jbc.m311191200

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Development of a High-Throughput Assay for Two Inositol-Specific Phospholipase Cs Using a Scintillation Proximity Format

Autor: Heidi Spurling, Wei Cao, Linda Chee, Susan M. Fish, Sadhana Jain, Ping Li, Michael E. Bembenek, Mihail Rokas, Rachel Meyers, Thomas F. Parsons, Rebecca Roy, Andrea Prack

Publikováno v: ASSAY and Drug Development Technologies. 1:435-443

Inositol-specific PLCs comprise a family of enzymes that utilize phosphoinositide substrates, e.g., PIP(2), to generate intracellular second messengers for the regulation of cellular responses. In the past, monitoring this reaction has been difficult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3802090e7133266537bb89bc6c614c
https://doi.org/10.1089/154065803322163740

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Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase

Autor: Larry Dick, Virendar K. Kaushik, Thomas F. Parsons, Peter J. Tummino, Susan L. Acton, Michael A. Patane, Kevin Godbout, Jin Tang, Elizabeth Baronas, Chad S Vickers, Frank Y. Hsieh, James M. Gavin, Paul Hales, Andrew J. Nichols

Publikováno v: Journal of Biological Chemistry. 277:14838-14843

Human angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a zinc metalloprotease whose closest homolog is angiotensin I-converting enzyme. To begin to elucidate the physiological role of ACE2, ACE2 was purified, and its catalytic activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929451542d182d05289629c030cb7bc5
https://doi.org/10.1074/jbc.m200581200

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