Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Thomas F. Palmberger"'
Publikováno v:
Drug Delivery. 16:254-260
This study evaluated thiolated poly(acrylic acid) nanoparticles as a valuable tool to protect insulin from degradation by serinproteases of the intestine. Nanaoparticles were characterized concerning particle size, zeta potential, and drug load. Furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85b59e912f2f67875afac2022508631
https://doi.org/10.1080/10717540902937471
https://doi.org/10.1080/10717540902937471
Autor:
Vjera Grabovac, Martin H. Hoffer, Andreas Bernkop-Schnürch, Thomas F. Palmberger, Thierry Schmitz
Publikováno v:
International Journal of Pharmaceutics. 347:79-85
The aim of the present study was to synthesize and characterize a novel thiolated polymer by covalent attachment of N-acetyl cysteine to chitosan. The obtained conjugate was characterized in vitro by quantification of immobilized thiol groups and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5265e8f3841f48f2619bfb8fdbb2ad
https://doi.org/10.1016/j.ijpharm.2007.06.040
https://doi.org/10.1016/j.ijpharm.2007.06.040
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 66:405-412
It was the aim of this study to investigate the influence of the amount of thiol groups being covalently attached to poly(acrylic acid) 450 kDa on its properties. Five different PAA 450 – l -cysteine conjugates (PAA 450 –Cys) were synthesized bea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b984dcaee01b2e2775730957ac3eeb9d
https://doi.org/10.1016/j.ejpb.2006.11.017
https://doi.org/10.1016/j.ejpb.2006.11.017
Autor:
Thomas F. Palmberger, Marlene Thaler, Britta Deutel, Andreas Bernkop-Schnürch, Andreas Saxer, Flavia Laffleur
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 81
This study focused on a novel two step preparation method for the generation of insulin containing thiomer microparticles. The first step utilized the interpolymer complexation between poly(vinyl pyrrolidone) (PVP) and poly(acrylic acid) (PAA) or pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a340e906efca052108019155f38065cb
https://pubmed.ncbi.nlm.nih.gov/26517960
https://pubmed.ncbi.nlm.nih.gov/26517960
In vivo evaluation of anionic thiolated polymers as oral delivery systems for efflux pump inhibition
Publikováno v:
International journal of pharmaceutics. 491(1-2)
Recently, the cationic polymer thiolated chitosan has been reported to modulate drug absorption by inhibition of intestinal efflux pumps. The objective of this study was to evaluate in vitro and in vivo whether thiolated anionic biopolymers also show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aae38e802d2ecd3c0d25100be68f2d0
https://pubmed.ncbi.nlm.nih.gov/26095915
https://pubmed.ncbi.nlm.nih.gov/26095915
Autor:
E. J. Zirm, Karin Albrecht, Wolfgang Schlocker, Thomas F. Palmberger, Andreas Bernkop-Schnürch
Publikováno v:
Drug Development and Industrial Pharmacy. 32:1149-1157
It was the aim of this study to develop mucoadhesive microparticulate delivery systems based on thiomers and to investigate parameters influencing their mucoadhesive properties. Microparticles were prepared via coazervation of thiolated or unmodified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2198d2c2d2678df239baa69a779001
https://doi.org/10.1080/03639040600712334
https://doi.org/10.1080/03639040600712334
Autor:
Andreas Bernkop-Schnürch, Thomas F. Palmberger, M. Dorly Del Curto, G.M. Sprinzl, Mauro D'Antonio, Alexander Greimel
Publikováno v:
Scopus-Elsevier
The purpose of the present study was to compare two preparation methods concerning the development of a thiomer (polycarbophil-cysteine; PCP-Cys)-based microparticidate delivery system for nasal drug administration. Microparticles were prepared eithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad570f3be5e919d56f4bcca9c87ed4e0
https://doi.org/10.1016/s1773-2247(06)50015-2
https://doi.org/10.1016/s1773-2247(06)50015-2
Publikováno v:
Drug development and industrial pharmacy. 37(12)
The aim of this study was to investigate the nasal safety of gel formulations of thiolated polymers (thiomers) by assessing their effect on ciliary beat frequency (CBF) in human nasal epithelial cells.Poly(acrylic acid) 450 kDa-cysteine (PAA-cys) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08a1d6eb1028f20317456135039b82f
https://pubmed.ncbi.nlm.nih.gov/21635138
https://pubmed.ncbi.nlm.nih.gov/21635138
Publikováno v:
Journal of pharmaceutical sciences. 98(2)
The purpose of the present study was to design and evaluate a novel vaginal delivery system for nystatin based on mucoadhesive polymers. L-Cysteine and cysteamine, respectively, were covalently attached to poly(acrylic acid), and the two different th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3597c8b72c79bc5618ea626a9c804f
https://pubmed.ncbi.nlm.nih.gov/18563796
https://pubmed.ncbi.nlm.nih.gov/18563796
Publikováno v:
International journal of pharmaceutics. 348(1-2)
The aim of the study was to develop a novel oral delivery system for the efflux pump substrate acyclovir (ACY) utilizing thiolated chitosan as excipient which is capable of inhibiting P-glycoprotein (P-gp). Three chitosan–4-thiobutylamidine (Chito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bce6f3181b2c9bbc2996e9898cc127
https://pubmed.ncbi.nlm.nih.gov/17716840
https://pubmed.ncbi.nlm.nih.gov/17716840