Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thomas F. Pack"'
Autor:
Jeffrey S. Smith, Haley Hanseler, John Welle, Rogan Rattray, Mary Campbell, Tacy Brotherton, Tarsem Moudgil, Thomas F. Pack, Keith Wegmann, Shawn Jensen, Justin Jin, Carlo B. Bifulco, Scott A. Prahl, Bernard A. Fox, Nicholas L. Stucky
Publikováno v:
Journal of Clinical and Translational Science, Vol 5 (2021)
Abstract Introduction: The COVID-19 pandemic has created a high demand on personal protective equipment, including disposable N95 masks. Given the need for mask reuse, we tested the feasibility of vaporized hydrogen peroxide (VHP), ultraviolet light
Externí odkaz:
https://doaj.org/article/ea972a4eaf344f10a35f931c8abb5ab5
Autor:
Kevin Zheng, Jeffrey S. Smith, Dylan S. Eiger, Anmol Warman, Issac Choi, Christopher C. Honeycutt, Noelia Boldizsar, Jaimee N. Gundry, Thomas F. Pack, Asuka Inoue, Marc G. Caron, Sudarshan Rajagopal
Publikováno v:
Sci Signal
G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors and signal through the proximal effectors, G proteins and β-arrestins, to influence nearly every biological process. The G protein and β-arrestin signaling pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf643520cd8d79542b28b8fb6f94fe4b
https://europepmc.org/articles/PMC9890572/
https://europepmc.org/articles/PMC9890572/
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141637 (2015)
Functional selectivity (or biased agonism) is a property exhibited by some G protein-coupled receptor (GPCR) ligands, which results in the modulation of a subset of a receptor's signaling capabilities and more precise control over complex biological
Externí odkaz:
https://doaj.org/article/ea4b595eb4b6494288e1d48938178cfd
Autor:
P. J. Nicholls, Thomas F. Pack, Nikhil M. Urs, Sunil Kumar, Yang Zhou, Gabriel Ichim, Joshua D. Ginzel, Gabor Turu, Evan Calabrese, Wendy L. Roberts, Ping Fan, Valeriy G. Ostapchenko, Monica S. Guzman Lenis, Flavio Beraldo, Jiri Hatina, Vania F. Prado, Marco A. M. Prado, Ivan Spasojevic, Joshua C. Snyder, Kafui Dzirasa, G. Allan Johnson, Marc G. Caron
Publikováno v:
eNeuro
eNeuro, 2022, 9 (5), pp.ENEURO.0147-21.2022. ⟨10.1523/ENEURO.0147-21.2022⟩
eNeuro, 2022, 9 (5), pp.ENEURO.0147-21.2022. ⟨10.1523/ENEURO.0147-21.2022⟩
The protease caspase-3 is a key mediator of apoptotic programmed cell death. But weak or transient caspase activity can contribute to neuronal differentiation, axonal pathfinding, and synaptic long-term depression. Despite the importance of sublethal
Autor:
Claudia Lee, Jeffrey S. Smith, Dean P. Staus, Sudarshan Rajagopal, Thomas F. Pack, Issac Choi, Xinyu Xiong, Zhiyuan Ma, Dylan Eiger, Ian M. Levitan, Gayathri Viswanathan, Alem W. Kahsai, Kevin Zheng, Joshua C. Snyder, Marc G. Caron, Anmol Warman, Asuka Inoue, Lauren K. Rochelle
Publikováno v:
Science. 371
Another way for GPCRs to signal G protein–coupled receptors (GPCRs) normally transmit signals by coupling to heterotrimeric guanine nucleotide–binding proteins (G proteins) or by binding β-arrestin proteins. Smith et al. provide evidence for ano
Autor:
Thomas F. Pack, Jeffrey S. Smith
Publikováno v:
The FEBS journalReferences. 288(8)
G protein-coupled receptors (GPCRs) canonically couple to specific Gα protein subtypes and β-arrestin adaptor proteins to initiate cellular signaling events. G protein-mediated signaling and β-arrestin-mediated signaling have broadly been consider
Autor:
Issac Choi, Jaimee N. Gundry, Sudarshan Rajagopal, Marc G. Caron, Asuka Inoue, Thomas F. Pack, Kevin Zheng, Jeffrey S. Smith, Anmol Warman
G-protein-coupled receptors (GPCRs), the largest family of cell surface receptors, signal through the proximal effectors G proteins and β-arrestins to influence nearly every biological process. Classically, the G protein and β-arrestin signaling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dca5d5df4105f95ea21bcda14cf6d73
https://doi.org/10.1101/2020.06.11.146605
https://doi.org/10.1101/2020.06.11.146605
Autor:
Kaitlin Payne, Marc G. Caron, Thomas F. Pack, Emiliana Borrelli, Samuel J Rose, Sean M. Peterson
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 43, iss 5
The dopamine D2 receptor (D2R), like many G-protein-coupled receptors, signals through G-protein- and β-arrestin-dependent pathways. Preferential activation of one of these pathways is termed functional selectivity or biased signaling and is a promi
Autor:
Alan S. Waggoner, Lauren K. Rochelle, Larry S. Barak, Veronica Lubkov, Marc G. Caron, Caroline A. Ray, Cheryl B. Bock, Thomas F. Pack, Joshua C. Snyder, H. Kim Lyerly
Publikováno v:
Journal of Biological Chemistry. 292:7208-7222
The leucine-rich G protein-coupled receptor-5 (LGR5) is expressed in adult tissue stem cells of many epithelia, and its overexpression is negatively correlated with cancer prognosis. LGR5 potentiates WNT/β-catenin signaling through its unique consti
Autor:
Jeffrey S, Smith, Thomas F, Pack, Asuka, Inoue, Claudia, Lee, Kevin, Zheng, Issac, Choi, Dylan S, Eiger, Anmol, Warman, Xinyu, Xiong, Zhiyuan, Ma, Gayathri, Viswanathan, Ian M, Levitan, Lauren K, Rochelle, Dean P, Staus, Joshua C, Snyder, Alem W, Kahsai, Marc G, Caron, Sudarshan, Rajagopal
Publikováno v:
Science
Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) are common drug targets and canonically couple to specific G(α) protein subtypes and β-arrestin adaptor proteins. G protein–mediated signaling and β-arre