Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thomas F. McNamara"'
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3597-3604.e3 (2020)
Summary: Cultured pluripotent cells accumulate detrimental chromatin alterations, including DNA methylation changes at imprinted genes known as loss of imprinting (LOI). Although the occurrence of LOI is considered a stochastic phenomenon, here we do
Externí odkaz:
https://doaj.org/article/ebf7ded8496b47599c3fd739255493c8
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3597-3604.e3 (2020)
Summary: Cultured pluripotent cells accumulate detrimental chromatin alterations, including DNA methylation changes at imprinted genes known as loss of imprinting (LOI). Although the occurrence of LOI is considered a stochastic phenomenon, here we do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102fd7056db67cc0ba44233f7f95e555
https://doi.org/10.1101/2020.01.25.915413
https://doi.org/10.1101/2020.01.25.915413
Autor:
Karen H. Miga, Mamta Tahiliani, Schildkraut C, Narayan S, Patrick Griffin, Delpu Y, Kaleem S, Thomas F. McNamara
Cancer cells, aging cells, and cells from patients with the developmental disorder Immunodeficiency, Centromeric instability, and Facial anomalies (ICF) syndrome frequently display a striking loss of DNA methylation (hypomethylation) that is accompan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef41f73750c4998f3d026ade762838ca
https://doi.org/10.1101/554410
https://doi.org/10.1101/554410
Autor:
L. M. Golub, Dr.D. Grenier, Thomas F. Mcnamara, H-M. Lee, Denis Mayrand, N. S. Ramamurthy, Pascale Plamondon, Timo Sorsa, Olli Teronen
Publikováno v:
Journal of Periodontology. 73:79-85
Tetracyclines, particularly doxycycline (Doxy), and their non-antimicrobial chemically-modified derivatives (CMTs) inhibit the activities of human matrix metalloproteinases (MMPs), and reduce the severity and progression of periodontal disease in ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db84bd15c1f8338c869a4fec12693be0
https://doi.org/10.1902/jop.2002.73.1.79
https://doi.org/10.1902/jop.2002.73.1.79
Autor:
Leon W. Hodes, Henry D. Perry, Eric D. Donnenfeld, Lorne M. Golub, Thomas F. Mcnamara, John A. Seedor
Publikováno v:
Cornea. 12:379-382
We examined the effects of doxycycline hyclate on epithelial healing in vivo in the rabbit alkali-burn model. Twelve 2-3-kg Dutch belted rabbits were divided into three groups and received standard bilateral alkali burns (1 N sodium hydroxide for 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec4b0ffba50c4382c5d9e7dd8fcd427
https://doi.org/10.1097/00003226-199309000-00002
https://doi.org/10.1097/00003226-199309000-00002
Publikováno v:
Biochemical Medicine and Metabolic Biology. 47:10-20
Chemically modified tetracycline (4-de-dimethylamino tetracycline), like commercially available tetracyclines, is known to inhibit experimentally induced pathologic collagen breakdown. A method for measurement of chemically modified tetracycline in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5113db8c273cb648b7e3cfbaf8e60d5f
https://doi.org/10.1016/0885-4505(92)90003-h
https://doi.org/10.1016/0885-4505(92)90003-h
Low-dose doxycycline therapy: Effect on gingival and crevicular fluid collagenase activity in humans
Publikováno v:
Journal of Periodontal Research. 25:321-330
Tetracyclines are now recognized to have non-antimicrobial properties with therapeutic potential--for example, these agents can inhibit pathologic collagenolysis by blocking mammalian collagenases and other matrix-degrading metalloproteinases. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097b25b030e76286fa68e09e45632d38
https://doi.org/10.1111/j.1600-0765.1990.tb00923.x
https://doi.org/10.1111/j.1600-0765.1990.tb00923.x
Publikováno v:
Journal of periodontology. 62(5)
In this study, substantivity of topically applied doxycycline hydrochloride on root surfaces obtained from patients with periodontal disease was studied in vitro. Cementum and dentin specimens were impregnated with aqueous solutions of doxycycline fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0caaed0355a12b1f5456ea757d8b372
https://pubmed.ncbi.nlm.nih.gov/2072243
https://pubmed.ncbi.nlm.nih.gov/2072243
Publikováno v:
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2(3)
Tetracyclines have long been considered useful adjuncts in peridontal therapy based on their antimicrobial efficacy against putative periodontopathogens. However, recently these drugs were found to inhibit mammalian collagenases and several other mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f75550fe1b20736333303f6ac11fb5
https://pubmed.ncbi.nlm.nih.gov/1654139
https://pubmed.ncbi.nlm.nih.gov/1654139
Autor:
A. Nemiroff, N. S. Ramamurthy, G. Lehrer, Hsi-Ming Lee, R. Kaplan, L. M. Golub, Thomas F. Mcnamara
Publikováno v:
Journal of Periodontal Research. 18:516-526
Diabetes increases gingival collagenase activity, an effect that may be mediated by endogenous tissue changes and exacerbated by an overgrowth of Gram-negative organisms in the gingival crevice (see Ramamurthy & Golub 1983, McNamara et al. 1982). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbafb22d8373b8a3366ba56accc0b1b
https://doi.org/10.1111/j.1600-0765.1983.tb00388.x
https://doi.org/10.1111/j.1600-0765.1983.tb00388.x