Regulation of the ER stress response by a mitochondrial microprotein

Autor: Qian Chu, Thomas F. Martinez, Sammy Weiser Novak, Cynthia J. Donaldson, Dan Tan, Joan M. Vaughan, Tina Chang, Jolene K. Diedrich, Leo Andrade, Andrew Kim, Tong Zhang, Uri Manor, Alan Saghatelian

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Cells trigger an unfolded protein response (UPR) in the endoplasmic reticulum, but its regulation by mitochondria is unclear. Here, the authors report a 54-residue microprotein PIGBOS that participates in inter-organelle contact between the endoplasm

Externí odkaz: https://doaj.org/article/88ad530f1b6144599a5346421f1a1e1d

Profiling Mouse Brown and White Adipocytes to Identify Metabolically Relevant Small ORFs and Functional Microproteins

Autor: Thomas F. Martinez, Sally Lyons-Abbott, Angie L. Bookout, Cynthia Donaldson, Joan M. Vaughan, Calvin Lau, Ariel Abramov, Arian F. Baquero, Karalee Baquero, Dave Friedrich, Justin Huard, Ray Davis, Bong Kim, Ty Koch, Aaron J. Mercer, Ayesha Misquith, Sara A. Murray, Sakara Perry, Lindsay K. Pino, Christina Sanford, Alex Simon, Yu Zhang, Garrett Zipp, Maxim N. Shokhirev, Andrew J. Whittle, Brian C. Searle, Michael J. MacCoss, Alan Saghatelian, Christopher A. Barnes

SUMMARYThe absence of thousands of recently annotated small open reading frame (smORF)-encoded peptides and small proteins (microproteins) from databases has precluded their analysis in metabolism and metabolic disease. Given the outsized importance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c60053f4cebe996605878d3dbc60b0b
https://doi.org/10.1101/2022.03.12.484025

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.

Autor: Amanda E Hargrove, Thomas F Martinez, Alissa A Hare, Alexis A Kurmis, John W Phillips, Sudha Sud, Kenneth J Pienta, Peter B Dervan

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143161 (2015)

Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen respons

Externí odkaz: https://doaj.org/article/0e0f266dcfb74ee5b9dab35d6f5d1fe0

A short ORF-encoded transcriptional regulator

Autor: Michael J. Bollong, James J. Moresco, Minseob Koh, Yeonjin Ko, Peter G. Schultz, Thomas F. Martinez, Insha Ahmad, Michael A. Erb, Alan Saghatelian, Jolene K. Diedrich, Yuxiang Zhang, Qian Chu

Publikováno v: Proc Natl Acad Sci U S A

Recent technological advances have expanded the annotated protein coding content of mammalian genomes, as hundreds of previously unidentified, short open reading frame (ORF)-encoded peptides (SEPs) have now been found to be translated. Although sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d47869ae69bbc6ac8ad90c846a38ae
https://pubmed.ncbi.nlm.nih.gov/33468658

Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides

Autor: Amanda Silberstein, Lina He, Bogdan Olenyuk, Joseph W. Stiles, Tiezheng Jia, Thomas F. Martinez, Alissa A. Hare, Yang Li, Bangyan L. Stiles, Peter B. Dervan, John Gallagher, Chien-Yu Chen

Publikováno v: Med Chem Res
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, vol 29, iss 4

The orphan nuclear receptors estrogen-related receptors (ERRs) bind to the estrogen-related receptor response element (ERRE) to regulate transcriptional programs in cellular metabolism and cancer cell growth. In this study, we evaluated the potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4ef2e105e0b11764d04977cd0da9e9
https://resolver.caltech.edu/CaltechAUTHORS:20200226-143501183