Organic anion and cation SLC22 'drug' transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule.

Autor: Thomas F Gallegos, Gleb Martovetsky, Valentina Kouznetsova, Kevin T Bush, Sanjay K Nigam

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40796 (2012)

Proper physiological function in the pre- and post-natal proximal tubule of the kidney depends upon the acquisition of selective permeability, apical-basolateral epithelial polarity and the expression of key transporters, including those involved in

Externí odkaz: https://doaj.org/article/0ee75bd2aa1f4c73a2e242dda7d13d6c

The stretch responsive microRNA miR‐148a‐3p is a novel repressor of IKBKB , NF‐κB signaling, and inflammatory gene expression in human aortic valve cells

Autor: Vishal Patel, Thomas F. Gallegos, Andrew Hollands, Roman Sasik, Gary Hardiman, Victor Nizet, Salah A. Mohamed, Vishal Nigam, Charles C. King, Andrew Hinton, Katrina Carrion, Jeffrey Dyo, Emma Leire, Sanjay K. Nigam

Publikováno v: The FASEB Journal. 29:1859-1868

Bicuspid aortic valves calcify at a significantly higher rate than normal aortic valves, a process that involves increased inflammation. Because we have previously found that bicuspid aortic valve experience greater stretch, we investigated the poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cc537f65283e75b0abdf7d223221ab
https://doi.org/10.1096/fj.14-257808

Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate

Autor: Hiroyuki Sakurai, Derina E. Sweeney, Mita M. Shah, Jeffrey D. Esko, Kevin T. Bush, Sanjay K. Nigam, Thomas F. Gallegos

Publikováno v: Developmental Biology. 356:19-27

Heparan sulfate proteoglycans (HSPGs) are found in the basement membrane and at the cell-surface where they modulate the binding and activity of a variety of growth factors and other molecules. Most of the functions of HSPGs are mediated by the varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e96d2d3053cee30c01acc870f4d044
https://doi.org/10.1016/j.ydbio.2011.05.004

Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching

Autor: Sanjay K. Nigam, Kevin T. Bush, Thomas F. Gallegos, Mita M. Shah, Hiroyuki Sakurai, Jeffrey D. Esko, Derina E. Sweeney

Publikováno v: Developmental Biology. 339(2):354-365

Heparan sulfate proteoglycans (HSPGs) are central modulators of developmental processes likely through their interaction with growth factors, such as GDNF, members of the FGF and TGFβ superfamilies, EGF receptor ligands and HGF. Absence of the biosy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f263df9ea65a5d040094a0cac4227a

Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells

Autor: Thomas F. Gallegos, Min-Zu Wu, Josep M. Campistol, Yun Xia, Keiichiro Suzuki, Ilir Dubova, Emmanuel Nivet, Concepcion Rodriguez Esteban, Nuria Montserrat, Ignacio Sancho-Martinez, Juan Carlos Izpisua Belmonte, Daiji Okamura

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2013, 15 (12), pp.1507--1515. ⟨10.1038/ncb2872⟩
Nature Cell Biology, 2013, 15 (12), pp.1507--1515. ⟨10.1038/ncb2872⟩

International audience; Diseases affecting the kidney constitute a major health issue worldwide. Their incidence and poor prognosis affirm the urgent need for the development of new therapeutic strategies. Recently, differentiation of pluripotent cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62ef693eeac56cfe3aabd316b70b81d
https://pubmed.ncbi.nlm.nih.gov/24296625