Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

Autor: Kaylee M. Keller, Thomas F. Eleveld, Linda Schild, Kim van den Handel, Marlinde van den Boogaard, Vicky Amo-Addae, Selma Eising, Kimberley Ober, Bianca Koopmans, Leendert Looijenga, Godelieve A.M. Tytgat, Bauke Ylstra, Jan J. Molenaar, M. Emmy M. Dolman, Sander R. van Hooff

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Neuroblastoma is the most common extracranial solid tumor found in children and despite intense multi-modal therapeutic approaches, low overall survival rates of high-risk patients persist. Tumors with heterozygous loss of chromosome 11q and MYCN amp

Externí odkaz: https://doaj.org/article/2046bd60d71d42bd8c11809b13f2595a

Data from RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma

Autor: Jan J. Molenaar, Rogier Versteeg, Peter van Sluis, Godelieve A. Tijtgat, Richard Volckmann, Marli E. Ebus, Lindy K. Alles, Danny A. Zwijnenburg, Jan Koster, Linda Schild, Thomas F. Eleveld

Mutations affecting the RAS–MAPK pathway frequently occur in relapsed neuroblastoma tumors, which suggests that activation of this pathway is associated with a more aggressive phenotype. To explore this hypothesis, we generated several model system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf93e63bcd3155267314d8a3b712bd87
https://doi.org/10.1158/0008-5472.c.6510512.v1

Engineering large-scale chromosomal deletions by CRISPR-Cas9

Autor: Pino J Poddighe, Phylicia Stathi, Paul P. Eijk, Thomas F Eleveld, Lianne E Vriend, Chaimaa Bakali, Bauke Ylstra

Publikováno v: Nucleic Acids Research, 49(21), 12007-12016. Oxford University Press
Eleveld, T F, Bakali, C, Eijk, P P, Stathi, P, Vriend, L E, Poddighe, P J & Ylstra, B 2021, ' Engineering large-scale chromosomal deletions by CRISPR-Cas9 ', Nucleic Acids Research, vol. 49, no. 21, pp. 12007-12016 . https://doi.org/10.1093/nar/gkab557
Nucleic Acids Research

Large-scale chromosomal deletions are a prevalent and defining feature of cancer. A high degree of tumor-type and subtype specific recurrencies suggest a selective oncogenic advantage. However, due to their large size it has been difficult to pinpoin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f3d7536d97b3f77157e5021d45333f
https://doi.org/10.1093/nar/gkab557

Mek Inhibition Causes BIM Stabilization and Increased Sensitivity to BCL-2 Family Member Inhibitors in RAS-MAPK-Mutated Neuroblastoma

Autor: Thomas F. Eleveld, Lindy Vernooij, Linda Schild, Bianca Koopmans, Lindy K. Alles, Marli E. Ebus, Rana Dandis, Harm van Tinteren, Huib N. Caron, Jan Koster, Max M. van Noesel, Godelieve A. M. Tytgat, Selma Eising, Rogier Versteeg, M. Emmy M. Dolman, Jan J. Molenaar

Publikováno v: SSRN Electronic Journal.

IntroductionMutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition in vitro. However, these inhibitors alone do not lead to tumor regression in vivo, indicating th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ba435d3f0c30f2d362145ad2d44ae4
https://doi.org/10.2139/ssrn.4164974

MEK inhibition causes Bim stabilization and sensitivity to Bcl2 family member inhibitors in RAS-MAPK mutated neuroblastoma

Autor: Bianca Koopmans, Thomas F. Eleveld, Lindy Vernooij, Rogier Versteeg, Emmy Dolman, Huib N. Caron, Marli E. Ebus, Jan Koster, Lindy K. Alles, Peter van Sluis, Linda Schild, Jan J. Molenaar

Mutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition in vitro. However, these inhibitors alone do not lead to tumor regression in vivo, indicating the need for c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a149c61ba3deceda7fd2cabb881ad8a7
https://doi.org/10.1101/2020.02.12.945089