Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Thomas F. Duchaine"'
Autor:
Caroline Thivierge, Maxime Bellefeuille, Sarah-Slim Diwan, Boris J.A. Dyakov, Rania Leventis, Gabrielle Perron, Hamed S. Najafabadi, Simon-Pierre Gravel, Anne-Claude Gingras, Thomas F. Duchaine
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114695- (2024)
Summary: MicroRNAs (miRNAs) play crucial roles in physiological functions and disease, but the regulation of their nuclear biogenesis remains poorly understood. Here, BioID on Drosha, the catalytic subunit of the microprocessor complex, reveals its p
Externí odkaz:
https://doaj.org/article/a21957db8b6548129e9b0cdd0570964c
Autor:
Elva Vidya, Thomas F. Duchaine
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation. Enzyme-directed hydrolysis of the cap (decapping) decisively affects mRNA
Externí odkaz:
https://doaj.org/article/486ed068f0184f5c9cc96143804be015
Autor:
Said Izreig, Alexandra Gariepy, Irem Kaymak, Hannah R. Bridges, Ariel O. Donayo, Gaëlle Bridon, Lisa M. DeCamp, Susan M. Kitchen-Goosen, Daina Avizonis, Ryan D. Sheldon, Rob C. Laister, Mark D. Minden, Nathalie A. Johnson, Thomas F. Duchaine, Marc S. Rudoltz, Sanghee Yoo, Michael N. Pollak, Kelsey S. Williams, Russell G. Jones
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 2, Pp 100014- (2020)
Summary: Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK) p
Externí odkaz:
https://doaj.org/article/d6a25ea75c0340f4b7b742c8469caad8
Autor:
Vinay K. Mayya, Thomas F. Duchaine
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The sequences and structures of 3′-untranslated regions (3′UTRs) of messenger RNAs govern their stability, localization, and expression. 3′UTR regulatory elements are recognized by a wide variety of trans-acting factors that include microRNAs (
Externí odkaz:
https://doaj.org/article/a89ef5133db040b49381f3ec5a127c1d
Autor:
Said Izreig, Bozena Samborska, Radia M. Johnson, Alexey Sergushichev, Eric H. Ma, Carine Lussier, Ekaterina Loginicheva, Ariel O. Donayo, Maya C. Poffenberger, Selena M. Sagan, Emma E. Vincent, Maxim N. Artyomov, Thomas F. Duchaine, Russell G. Jones
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1915-1928 (2016)
A central hallmark of cancer cells is the reprogramming of cellular metabolism to meet the bioenergetic and biosynthetic demands of malignant growth. Here, we report that the miR-17∼92 microRNA (miRNA) cluster is an oncogenic driver of tumor metabo
Externí odkaz:
https://doaj.org/article/c358bda8327145d5b97bb7af9103a9a2
Autor:
Ahilya N. Sawh, Thomas F. Duchaine
Publikováno v:
Cell Reports, Vol 4, Iss 3, Pp 454-463 (2013)
The RNase III enzyme Dicer is responsible for key steps in the biogenesis of small RNA species in multiple RNA interference pathways. Here, we show that, in the adult C. elegans soma, half of the total DCR-1 protein is expressed as a truncated, stabl
Externí odkaz:
https://doaj.org/article/d43cc2cbca76480c8281c9fafdb676cd
Autor:
Patricia Giselle Cipriani, Olivia Bay, John Zinno, Michelle Gutwein, Hin Hark Gan, Vinay K Mayya, George Chung, Jia-Xuan Chen, Hala Fahs, Yu Guan, Thomas F Duchaine, Matthias Selbach, Fabio Piano, Kristin C Gunsalus
Publikováno v:
eLife, Vol 10 (2021)
We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P granule condensation, form granules independently of MEG-3 in the postembryonic g
Externí odkaz:
https://doaj.org/article/5376ad2b9c1849d09f6a60306a309c25
Autor:
Parisa Naeli, Xu Zhang, Patric Leo Harris Snell, Susanta Chatterjee, Muhammad Kamran, Reese Jalal Ladak, Nick Orr, Thomas F Duchaine, Nahum Sonenberg, Seyed Mehdi Jafarnejad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::352a403ba84ff0781bcfcd8a3ba087dc
https://doi.org/10.15252/rc.2023711471
https://doi.org/10.15252/rc.2023711471
Autor:
Seyed Mehdi Jafarnejad, Clément Chapat, Edna Matta-Camacho, Idit Anna Gelbart, Geoffrey G Hesketh, Meztli Arguello, Aitor Garzia, Sung-Hoon Kim, Jan Attig, Maayan Shapiro, Masahiro Morita, Arkady Khoutorsky, Tommy Alain, Christos, G Gkogkas, Noam Stern-Ginossar, Thomas Tuschl, Anne-Claude Gingras, Thomas F Duchaine, Nahum Sonenberg
Publikováno v:
eLife, Vol 7 (2018)
MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs. We recently discovered that the cap-binding protein 4EHP is a key component of the mammalian miRNA-In
Externí odkaz:
https://doaj.org/article/bfdd543ac6d44c1295839d61e81be1b1
Autor:
Nahum Sonenberg, Mathieu N. Flamand, James A. Wohlschlegel, Alice M Lambert, Vinay K. Mayya, Thomas F. Duchaine, Seyed Mehdi Jafarnejad
Publikováno v:
Mayya, V K, Flamand, M N, Lambert, A M, Jafarnejad, S M, Wohlschlegel, J A, Sonenberg, N & Duchaine, T F 2021, ' microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkab162
Nucleic Acids Research
Nucleic Acids Research
microRNA (miRNA)-mediated gene silencing is enacted through the recruitment of effector proteins that direct translational repression or degradation of mRNA targets, but the relative importance of their activities for animal development remains unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4905c393cc28ee1e390536c93351b1
https://doi.org/10.1093/nar/gkab162
https://doi.org/10.1093/nar/gkab162