Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Thomas F. DeKoning"'
Autor:
Steve A. Mizsak, Thomas F. DeKoning, Sally J. Mattern, David A. Yurek, Ming-Shang Kuo, Mark D. Prairie
Publikováno v:
Journal of Pharmaceutical Sciences. 88:705-708
PNU‐107859, an important representative structure in a novel class of matrix metalloproteinases (MMP) inhibitors known as thiadiazoles, was found to be quickly eliminated from rats. A major metabolite (approximately 10% of total dose) was found to
Autor:
Thomas F. DeKoning, I. Gebhard, Kelly Robert C, J. Patrick McGovren, L. H. Li, Martha A. Warpehoski
Publikováno v:
Investigational New Drugs. 9:137-148
Adozelesin (U-73975) is a potent synthetic cyclopropylpyrroloindole (CPI) analog of the cytotoxic DNA-binding antibiotic, CC-1065. In contrast to the natural product, adozelesin and related CPI analogs do not cause delayed death in non-tumored mice.
Autor:
S. J. Mattern, Pitts Tw, Roy A. Johnson, Eldon G. Nidy, Thomas F. DeKoning, Chidester Cg, I. Gebhard, Paul J. Dobrowolski, Samuel J. Qualls, J. P. McGovren, Lopes Nm, Wicnienski Nancy Anne, Kelly Robert C, Weed Sd
Publikováno v:
Journal of medicinal chemistry. 40(18)
Publikováno v:
The Journal of Antibiotics. 37:63-70
It was previously shown that the potent new DNA-binding antibiotic, CC-1065, prolonged life span, but was not curative, when administered to mice bearing a variety of transplantable tumors. In this paper we show results of preliminary studies indicat
Autor:
Martha A. Warpehoski, William C. Krueger, Tanya L. Wallace, Mark D. Prairie, Thomas F. DeKoning, L. H. Li, Kelly Robert C
Publikováno v:
Investigational New Drugs. 5:329-337
CC-1065 was found to cause delayed toxicity at therapeutic doses, therefore, a large number of analogs have since been synthesized. A series of analogs with simplified but closely related structures were chosen for this investigation because some wer