Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Thomas F Vogt"'
Autor:
Lucile Megret, Barbara Gris, Satish Sasidharan Nair, Jasmin Cevost, Mary Wertz, Jeff Aaronson, Jim Rosinski, Thomas F Vogt, Hilary Wilkinson, Myriam Heiman, Christian Neri
Publikováno v:
eLife, Vol 10 (2021)
Loss of cellular homeostasis has been implicated in the etiology of several neurodegenerative diseases (NDs). However, the molecular mechanisms that underlie this loss remain poorly understood on a systems level in each case. Here, using a novel comp
Externí odkaz:
https://doaj.org/article/6b1d0cbc21bb45b297ea7b0f27e6a897
Autor:
Peter Langfelder, Fuying Gao, Nan Wang, David Howland, Seung Kwak, Thomas F Vogt, Jeffrey S Aaronson, Jim Rosinski, Giovanni Coppola, Steve Horvath, X William Yang
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190550 (2018)
In Huntington's disease (HD) patients and in model organisms, messenger RNA transcriptome has been extensively studied; in contrast, comparatively little is known about expression and potential role of microRNAs. Using RNA-sequencing, we have quantif
Externí odkaz:
https://doaj.org/article/b8777b2d13824572b2030ef761c7666a
Autor:
Maura Galimberti, Maria R. Nucera, Vittoria D. Bocchi, Paola Conforti, Elena Vezzoli, Matteo Cereda, Camilla Maffezzini, Raffaele Iennaco, Andrea Scolz, Andrea Falqui, Chiara Cordiglieri, Martina Cremona, Ira Espuny-Camacho, Andrea Faedo, Dan P. Felsenfeld, Thomas F. Vogt, Valeria Ranzani, Chiara Zuccato, Dario Besusso, Elena Cattaneo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Huntington’s disease (HD) causes selective degeneration of striatal and cortical neurons, resulting in cell mosaicism of coexisting still functional and dysfunctional cells. The impact of non-cell autonomous mechanisms between these cellul
Externí odkaz:
https://doaj.org/article/f886204e00154c1a8e03cf3cdc9d56ff
DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
Autor:
Ake T. Lu, Pritika Narayan, Matthew J. Grant, Peter Langfelder, Nan Wang, Seung Kwak, Hilary Wilkinson, Richard Z. Chen, Jian Chen, C. Simon Bawden, Skye R. Rudiger, Marc Ciosi, Afroditi Chatzi, Alastair Maxwell, Timothy A. Hore, Jeff Aaronson, Jim Rosinski, Alicia Preiss, Thomas F. Vogt, Giovanni Coppola, Darren Monckton, Russell G. Snell, X. William Yang, Steve Horvath
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Although Huntington’s disease (HD) is a well-studied genetic disorder, less is known about the epigenetic changes underlying it. Here, the authors characterize DNA methylation levels in tissues from patients, a mouse huntingtin (Htt) gene knock-in
Externí odkaz:
https://doaj.org/article/9415f3c0bb6441ffad6d13aeb09b8ee8
Autor:
Natsuko Macabuag, William Esmieu, Perla Breccia, Rebecca Jarvis, Wesley Blackaby, Ovadia Lazari, Liudvikas Urbonas, Maria Eznarriaga, Rachel Williams, Annelieke Strijbosch, Rhea Van de Bospoort, Kim Matthews, Cole Clissold, Tammy Ladduwahetty, Huw Vater, Patrick Heaphy, Douglas G. Stafford, Hong-Jun Wang, John E. Mangette, George McAllister, Vahri Beaumont, Thomas F. Vogt, Hilary A. Wilkinson, Elizabeth M. Doherty, Celia Dominguez
Publikováno v:
Journal of medicinal chemistry. 65(18)
Huntington's disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from a CAG repeat expansion in the huntingtin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9b7293f23145d9276a05495bc08822
https://pubmed.ncbi.nlm.nih.gov/36098485
https://pubmed.ncbi.nlm.nih.gov/36098485
Autor:
Jung-Hoon Lee, Maren Thomsen, Herwin Daub, Stefan C. Steinbacher, Agnieszka Sztyler, Gabriel Thieulin-Pardo, Tobias Neudegger, Nikolay V. Plotnikov, Ravi R. Iyer, Hilary A. Wilkinson, Edith Monteagudo, Dan P. Felsenfeld, Tasir S. Haque, Michael Finley, Celia Dominguez, Thomas F. Vogt, Brinda C. Prasad
Huntington’s disease (HD) is fatal neurodegenerative disorder caused by the expansion of a CAG-repeat tract in the huntingtin (HTT) gene. Human and mouse genetics studies have demonstrated a role for DNA mismatch repair (MMR) proteins which control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183b5ff9f85869d81d144088519fcbbf
https://doi.org/10.1101/2023.05.08.539930
https://doi.org/10.1101/2023.05.08.539930
Autor:
Manfred Kraus, Jannik N. Andersen, Peter Blume-Jensen, Nancy Kohl, Victoria Richon, Giulio Draetta, Martin L. Scott, Roderick T. Bronson, Shailaja Kasibhatla, Ekaterina V. Bobkova, Alan Northrup, Thomas F. Vogt, Myung K. Shin, Melissa Hurd, Paula Andrade, Erica Leccese, Minilik Angagaw, Nirah H. Shomer, Diana Gargano, Alessandra Di Bacco, Yusuf Erkul, Erin O'Hare, Kumiko Nagashima, Kun Hu, Yamicia Connor, Brian Dolinski, Kaiko Kunii, Heike Keilhack, Katharine Ellwood-Yen
Supplementary Figures 1-4 from PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828919a62a5a02040e157eb5ac219fb4
https://doi.org/10.1158/0008-5472.22390089
https://doi.org/10.1158/0008-5472.22390089
Autor:
Nan Wang, Peter Langfelder, Matthew Stricos, Lalini Ramanathan, Jeffrey B. Richman, Raymond Vaca, Mary Plascencia, Xiaofeng Gu, Shasha Zhang, T. Katherine Tamai, Liguo Zhang, Fuying Gao, Koliane Ouk, Xiang Lu, Leonid V. Ivanov, Thomas F. Vogt, Qing Richard Lu, A. Jennifer Morton, Christopher S. Colwell, Jeffrey S. Aaronson, Jim Rosinski, Steve Horvath, X. William Yang
Publikováno v:
Neuron. 110(20)
Brain tissue transcriptomes may be organized into gene coexpression networks, but their underlying biological drivers remain incompletely understood. Here, we undertook a large-scale transcriptomic study using 508 wild-type mouse striatal tissue samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102cf3176c3176500f2ba80c16ba4a22
https://pubmed.ncbi.nlm.nih.gov/36265442
https://pubmed.ncbi.nlm.nih.gov/36265442
Autor:
Margherita Verani, Paola Martufi, Celia Dominguez, Ramee Lee, Lara Petricca, Raffaele Ingenito, Cristina Cariulo, Daniel J. Lavery, Marco Finotto, Leticia Toledo-Sherman, Sean M. DeGuire, Andrea Caricasole, Thomas F. Vogt, Elizabeth M. Doherty, Hilal A. Lashuel
Publikováno v:
Biochemical and Biophysical Research Communications. 521:549-554
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of a CAG triplet repeat (encoding for a polyglutamine tract) within the first exon of the huntingtin gene. Expression of the mutant huntingtin (mHTT) protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708a06a05dc236486abebc8e82acb464
https://doi.org/10.1016/j.bbrc.2019.09.097
https://doi.org/10.1016/j.bbrc.2019.09.097
Autor:
Thomas F. Vogt, Satish Sasidharan Nair, Hilary Wilkinson, Lucile Megret, Jasmin Cevost, Mary H. Wertz, Barbara Gris, Christian Neri, Jeff Aaronson, Myriam Heiman, Jim Rosinski
Publikováno v:
A: Pathogenic mechanisms.
Background Although homeostasis holds great potential for neuroprotection in several neurodegenerative diseases, the global importance of homeostatic mechanisms in counteracting neurodegenerative disease has remained elusive in each case, due to diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49c25fd93ed7284d877ef4faaf8b8385
https://doi.org/10.1136/jnnp-2021-ehdn.3
https://doi.org/10.1136/jnnp-2021-ehdn.3