Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Thomas F Schilling"'
Autor:
Thomas F Schilling, Pierre Le Pabic
Publikováno v:
eLife, Vol 11 (2022)
A newly discovered enhancer region may have allowed vertebrates to evolve the ability to open and close their jaws.
Externí odkaz:
https://doaj.org/article/7f0aadec9fa5441cb2bf097b585be15a
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009077 (2021)
The vertebrate hindbrain is segmented into rhombomeres (r) initially defined by distinct domains of gene expression. Previous studies have shown that noise-induced gene regulation and cell sorting are critical for the sharpening of rhombomere boundar
Externí odkaz:
https://doaj.org/article/70871c8fd7b74d20bbcd554b7a7ddeca
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 11, p e1006569 (2018)
How does pattern formation occur accurately when confronted with tissue growth and stochastic fluctuations (noise) in gene expression? Dorso-ventral (D-V) patterning of the mandibular arch specifies upper versus lower jaw skeletal elements through a
Externí odkaz:
https://doaj.org/article/8c593382691a48bc859cf4965438e83e
Autor:
Raphaël Aguillon, Julie Batut, Arul Subramanian, Romain Madelaine, Pascale Dufourcq, Thomas F Schilling, Patrick Blader
Publikováno v:
eLife, Vol 7 (2018)
The zebrafish olfactory epithelium comprises a variety of neuronal populations, which are thought to have distinct embryonic origins. For instance, while ciliated sensory neurons arise from preplacodal ectoderm (PPE), previous lineage tracing studies
Externí odkaz:
https://doaj.org/article/9342fd89a923408f816c8c7ed53c6335
Autor:
Julian Sosnik, Likun Zheng, Christopher V Rackauckas, Michelle Digman, Enrico Gratton, Qing Nie, Thomas F Schilling
Publikováno v:
eLife, Vol 5 (2016)
Morphogen gradients induce sharply defined domains of gene expression in a concentration-dependent manner, yet how cells interpret these signals in the face of spatial and temporal noise remains unclear. Using fluorescence lifetime imaging microscopy
Externí odkaz:
https://doaj.org/article/b6f30c7fb588408684af3aed12061351
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004946 (2015)
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate embryo, including the craniofacial skeleton. Extensive filopodial protrusions in NC cells are thought to sense chemo-attractive/repulsive signals that provide
Externí odkaz:
https://doaj.org/article/85552832a5dc480990cc0b2df93777ab
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004726 (2014)
Organogenesis requires coordinated regulation of cellular differentiation and morphogenesis. Cartilage cells in the vertebrate skeleton form polarized stacks, which drive the elongation and shaping of skeletal primordia. Here we show that an atypical
Externí odkaz:
https://doaj.org/article/2f488425d66b4b15ba9a26825fc0a7b6
Autor:
Akihiko Muto, Shingo Ikeda, Martha E Lopez-Burks, Yutaka Kikuchi, Anne L Calof, Arthur D Lander, Thomas F Schilling
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004671 (2014)
Haploinsufficiency for Nipbl, a cohesin loading protein, causes Cornelia de Lange Syndrome (CdLS), the most common "cohesinopathy". It has been proposed that the effects of Nipbl-haploinsufficiency result from disruption of long-range communication b
Externí odkaz:
https://doaj.org/article/0cc2707f96b749de85ad05315b12ed65
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004479 (2014)
Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) cells, such as the subdivision of each pharyngeal arch into distinct dorsal (D) and ventral (V) elements. Wnt signaling has been implicated in many asp
Externí odkaz:
https://doaj.org/article/280d3e45930e4bc3adb7682d0417a7c0
Autor:
Arul Subramanian, Thomas F Schilling
Publikováno v:
eLife, Vol 3 (2014)
Tendons are extracellular matrix (ECM)-rich structures that mediate muscle attachments with the skeleton, but surprisingly little is known about molecular mechanisms of attachment. Individual myofibers and tenocytes in Drosophila interact through int
Externí odkaz:
https://doaj.org/article/9d10dc9c592b4900917e92baa168205b