Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Thomas F Murray"'
Autor:
Seksiri Arttamangkul, Andrew Plazek, Emily J Platt, Haihong Jin, Thomas F Murray, William T Birdsong, Kenner C Rice, David L Farrens, John T Williams
Publikováno v:
eLife, Vol 8 (2019)
Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we developed a fluores
Externí odkaz:
https://doaj.org/article/afd221fdbb4c475bbda925ce0c8607b0
Autor:
Paul D Boudreau, Emily A Monroe, Suneet Mehrotra, Shane Desfor, Anton Korobeynikov, David H Sherman, Thomas F Murray, Lena Gerwick, Pieter C Dorrestein, William H Gerwick
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133297 (2015)
Moorea producens JHB, a Jamaican strain of tropical filamentous marine cyanobacteria, has been extensively studied by traditional natural products techniques. These previous bioassay and structure guided isolations led to the discovery of two excitin
Externí odkaz:
https://doaj.org/article/ae3d2c5c905f4f1994a0b48cefa540c5
Publikováno v:
Molecules, Vol 29, Iss 13, p 3109 (2024)
Kappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders. The dynorphin A analog arodyn (Ac[Phe1,2,3,Arg4,D-Ala8]dynorphin A-(1–11)-NH2) exhibit
Externí odkaz:
https://doaj.org/article/8d3b986d7f6147a0b1fe93c1fed10a42
Autor:
Kristen H. Scherrer, Shainnel O. Eans, Jessica M. Medina, Sanjeewa N. Senadheera, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1218 (2023)
The macrocyclic tetrapeptide CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated
Externí odkaz:
https://doaj.org/article/e7827524f44543a88550968c9e396464
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 143, Iss , Pp 112173- (2021)
We explored the utility of the real-time FLIPR Membrane Potential (FMP) assay as a method to assess kappa opioid receptor (KOR)-induced hyperpolarization. The FMP Blue dye was used to measure fluorescent signals reflecting changes in membrane potenti
Externí odkaz:
https://doaj.org/article/19bfd0197221468483aed7a32e32fa3d
Publikováno v:
Marine Drugs, Vol 20, Iss 9, p 559 (2022)
N-methyl-D-aspartate (NMDA) receptors play a critical role in activity-dependent dendritic arborization, spinogenesis, and synapse formation by stimulating calcium-dependent signaling pathways. Previously, we have shown that brevetoxin 2 (PbTx-2), a
Externí odkaz:
https://doaj.org/article/b6b2b7f1f0e948ce94732a421b28066a
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 126, Iss , Pp 110060- (2020)
Arginine vasopressin (AVP) and oxytocin (OT) are nonapeptides that bind to G-protein coupled receptors and influence social behaviors. Consensus mammalian AVP and OT (Leu8-OT) sequences are highly conserved. In marmosets, an amino acid change in the
Externí odkaz:
https://doaj.org/article/2e54e52f827b46229e6c6461a84eb647
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 125, Iss , Pp 109832- (2020)
The oxytocin-arginine vasopressin (OT-AVP) ligand-receptor family influences a variety of physiological, behavioral, and social behavioral processes in the brain and periphery. The OT-AVP family is highly conserved in mammals, but recent discoveries
Externí odkaz:
https://doaj.org/article/eab0481612f34f7d84859cf141335073
Autor:
T. Andrew Bowdle, Nathan Sackett, Rick Strassman, Thomas F. Murray, Srdjan Jelacic, Charles Chavkin
Publikováno v:
Anesthesiology. 137(6)
Publikováno v:
Medicinal Chemistry Research. 30:1397-1407
The dynorphin (Dyn) A analog arodyn (Ac[Phe1-3,Arg4,d-Ala8]Dyn A-(1–11)NH2) is a κ opioid receptor-selective antagonist, but as a linear peptide it is conformationally flexible and subject to metabolism by proteases. To restrict its conformational