Výsledky vyhledávání - "Thomas F Haws"

Updated interim safety, biomarker, and efficacy data from Imagine-1: A phase 1/2 open-label, multicenter study to assess the safety, tolerability, and efficacy of a single dose, intra-cisterna magna (ICM) administration of PBGM01 in subjects with type I (early onset) and type IIA (late onset) infantile GM1 gangliosidosis (GM1)

Publikováno v: Molecular Genetics and Metabolism. 138:107169

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2595e1d8f08ff57da247d7806faa3b67
https://doi.org/10.1016/j.ymgme.2022.107169

Zobrazit plný text záznamu

A Randomized, Placebo-Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High-Density Lipoprotein Cholesterol in Subjects With Dyslipidemia

Autor: John J. Lepore, Kelly M. Mahar, Anne-Charlotte de Gouville, Thomas F Haws, Dennis L. Sprecher, Feng Gao, Michael J. Fossler, Eric Olson

Publikováno v: Clinical pharmacology in drug developmentReferences. 8(7)

GPR109A (HM74A), a G-protein-coupled receptor, is hypothesized to mediate lipid and lipoprotein changes and dermal flushing associated with niacin administration. GSK256073 (8-chloro-3-pentyl-1H-purine-2,6[3H,7H]-dione) is a selective GPR109A agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e131573b4df54b8b6cc9db4bd9cabe3e
https://pubmed.ncbi.nlm.nih.gov/31268250

Zobrazit plný text záznamu

Plný text ve formátu HTML

Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Ejection Fraction

Autor: Thomas F Haws, Robert J. Gropler, John J. Lepore, Michael J. Fossler, Laura Demopoulos, Victor G. Davila-Roman, Eric Olson, Zixing Fang, April M. Barbour, Stuart D. Russell

Publikováno v: JACC: Heart Failure. 4:559-566

Objectives This study sought to determine if glucagon-like peptide (GLP)-1 ameliorates myocardial metabolic abnormalities in chronic heart failure. Background Albiglutide (GSK716155) is a GLP-1 agonist indicated for type 2 diabetes. Methods We perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46c156398f9f77087d7d4a8461470f0f
https://doi.org/10.1016/j.jchf.2016.01.008

Zobrazit plný text záznamu

Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease

Autor: Thomas F Haws, Kelly M. Mahar, Laura Demopoulos, Erding Hu, Zixing Fang, Pu Qin, William R. Hiatt, Timothy A. Bauer, Eric Olson, John J. Lepore

Publikováno v: Vascular Medicine. 19:473-482

Hypoxia inducible factor (HIF) stabilization by HIF-prolyl hydroxylase (PHD) inhibitors may improve ischemic conditions such as peripheral artery disease (PAD). This multicenter, randomized, placebo-controlled study evaluated the safety and efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d22d721b9f7b58d1eeaa2e32ad7802
https://doi.org/10.1177/1358863x14557151

Zobrazit plný text záznamu

Elektronická kniha

Principles of Good Clinical Practice

Autor: Michael J. McGraw, Adam N. George, Shawn P. Shearn, Rigel L. Hall, Thomas F. Haws Jr

Part of'RPS Pharmacy Business Administration Series', this book offers good clinical practice guidelines. It includes standards on how clinical trials should be conducted, provide assurance of safety and efficacy of various drugs and protect human ri

Zobrazit plný text záznamu

Dexamethasone and tumor necrosis factor-alpha act together to induce the cellular inhibitor of apoptosis-2 gene and prevent apoptosis in a variety of cell types

Autor: Elizabeth A. Allegretto, Thomas F. Haws, Paul M. Collier, Rebecca L. Hanson, Juliane K. Mills, Timothy C. Burn, Reid M. Huber, Jeffrey C. Webster

Publikováno v: Endocrinology. 143(10)

Using microarray technology, we analyzed 12,000 genes for regulation by TNF-alpha and the synthetic glucocorticoid, dexamethasone, in the human lung epithelial cell line, A549. Only one gene was induced by both agents, the cellular inhibitor of apopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e61d4e2380a632d8590ebcfd0cb43ad
https://pubmed.ncbi.nlm.nih.gov/12239098

Zobrazit plný text záznamu

Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

Autor: Altaf Kassam, Paul L. Gunyuzlu, Kathleen Murphy, John Link, Gregory F Hollis, Bowman Miao, Mark J Rupar, Peter R. Young, Mark R. Cunningham, Timothy C. Burn, Reid M. Huber, Ranjan Mukherjee, Thomas F. Haws, Francoise Powell

Publikováno v: Gene. 290(1-2)

Bile acid biosynthesis is regulated by both feed-forward and feedback mechanisms involving a cascade of nuclear hormone receptors. Feed-forward regulation of the rate limiting enzyme in bile acid biosynthesis is provided by oxysterols through liver-X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403b63e762669e5c892be96a3663f660
https://pubmed.ncbi.nlm.nih.gov/12062799

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání