Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Thomas F, Deuel"'
Autor:
Thomas F. Deuel
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834:2219-2223
Anaplastic lymphoma kinase is essential in early development, differentiation, and maintenance of cell survival; nevertheless, the mechanism to activate ALK has remained elusive. ALK has remained an "Orphan Receptor." The studies cited below describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c89fb038934df30f73e9eda93936ac7
https://doi.org/10.1016/j.bbapap.2013.06.004
https://doi.org/10.1016/j.bbapap.2013.06.004
Autor:
Amena Tamkenath, Katherine Stidham, Heidi Erlandsen, Mary Elizabeth Wilson, Mary MacDougall, Jennifer E. Ames, Thomas F. Deuel, Olga A. Mamaeva, Pablo Perez-Pinera
Publikováno v:
Journal of Histochemistry & Cytochemistry. 60:366-375
Pleiotrophin (PTN) is an extracellular matrix–associated growth factor and chemokine expressed in mesodermal and ectodermal cells. It plays an important role in osteoblast recruitment and differentiation. There is limited information currently avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ba2b9264d1672e83399ae55ca780bb
https://doi.org/10.1369/0022155412439316
https://doi.org/10.1369/0022155412439316
Autor:
Thomas F. Deuel, María José Polanco, Pablo Perez-Pinera, Alessia Putelli, Gonzalo Herradón, Esther Gramage, Carmen González-Martín, Luis F. Alguacil, Laura Ezquerra
Publikováno v:
Addiction Biology. 15:403-412
Pleiotrophin (PTN), a neurotrophic factor with important roles in survival and differentiation of dopaminergic neurons, is up-regulated in the nucleus accumbens after amphetamine administration suggesting that PTN could modulate amphetamine-induced p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d929d71c6642b23438db76084acf756
https://doi.org/10.1111/j.1369-1600.2009.00202.x
https://doi.org/10.1111/j.1369-1600.2009.00202.x
Autor:
Pablo Perez-Pinera, Gonzalo Herradón, Esther Gramage, Thomas F. Deuel, Nuria Del Olmo, Luis F. Alguacil
Publikováno v:
Growth Factors. 27:189-194
Pleiotrophin (PTN) is a growth factor that has been shown to be involved in hippocampal synaptic plasticity and learning. To further understand the involvement of PTN in memory processes, we performed in vitro electrophysiological studies in PTN-stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3475a3eb19ea3453ed9f18906b8bab
https://doi.org/10.1080/08977190902906859
https://doi.org/10.1080/08977190902906859
Autor:
Yunchao Chang, Joanne E. Mortimer, Aurora Astudillo, Pablo Perez-Pinera, Olivia García-Suárez, Primitiva Menendez-Rodriguez, Thomas F. Deuel
Publikováno v:
Biochemical and Biophysical Research Communications. 362:5-10
Increasing evidence suggests mutations in human breast cancer cells that induce inappropriate expression of the 18-kDa cytokine pleiotrophin (PTN, Ptn) initiate progression of breast cancers to a more malignant phenotype. Pleiotrophin signals through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fd7fc653bebccf3d1d866a5291974c
https://doi.org/10.1016/j.bbrc.2007.06.050
https://doi.org/10.1016/j.bbrc.2007.06.050
Publikováno v:
Journal of Biological Chemistry. 282:28683-28690
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) first discovered as the constitutively active nucleophosmin-ALK oncoprotein in anaplastic large cell lymphomas (ALCL). Full-length ALK has a critical role in normal development and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::199d382127499119d5ffb65edf59e603
https://doi.org/10.1074/jbc.m704505200
https://doi.org/10.1074/jbc.m704505200
Publikováno v:
Biochemical and Biophysical Research Communications. 358:399-403
Pleiotrophin (PTN, Ptn) is an 18kDa cytokine expressed in human breast cancers. Since inappropriate expression of Ptn stimulates progression of breast cancer in transgenic mice and a dominant negative PTN reverses the transformed phenotype of human b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf84adc6033d4324755a4b0af8c94d15
https://doi.org/10.1016/j.bbrc.2007.04.137
https://doi.org/10.1016/j.bbrc.2007.04.137
Publikováno v:
Biochemical and Biophysical Research Communications. 351:336-339
Pleiotrophin (PTN, Ptn) is an 18 kD secretory cytokine that is expressed in many human cancers, including glioblastoma. In previous experiments, interruption of the constitutive PTN signaling in human U87MG glioblastoma cells that inappropriately exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b277105a1d1c51247c89fbbd9d95ddfe
https://doi.org/10.1016/j.bbrc.2006.09.148
https://doi.org/10.1016/j.bbrc.2006.09.148
Publikováno v:
Proceedings of the National Academy of Sciences. 103:9063-9068
The status of the 66-kDa human estrogen receptor-alpha (hER-alpha66) is a critical determinant in the assessment of the prognosis and in the design of treatment strategies of human breast cancer. Recently, we cloned the cDNA of an alternatively splic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c028c902fedc86ad74ab02ffaa5e1a6
https://doi.org/10.1073/pnas.0603339103
https://doi.org/10.1073/pnas.0603339103
Autor:
Pablo Perez-Pinera, Rong Zhong, Nan Zhang, Thomas F. Deuel, Gonzalo Herradón, Zhao Yi Wang, Laura Ezquerra
Publikováno v:
Biochemical and Biophysical Research Communications. 343:653-658
Neoplasms progress through genetic and epigenetic mutations that deregulate pathways in the malignant cell that stimulate more aggressive growth of the malignant cell itself and/or remodel the tumor microenvironment to support the developing tumor ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b015b1c017d6b8639ef881c80a28fd
https://doi.org/10.1016/j.bbrc.2006.03.006
https://doi.org/10.1016/j.bbrc.2006.03.006