Supplementary Table from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Autor: Sophie Postel-Vinay, Christopher J. Lord, Jessica A. Downs, Eric Deutsch, Jean-Charles Soria, Geneviève Almouzni, Jyoti S. Choudhary, Raphaël Margueron, Stephen J. Pettitt, Christophe Massard, Elaine Del Nery, Asha Konde, Clémence Astier, Asuka Kawai-Kawachi, Clémence Hénon, Samuel Jouny, Theodoros I. Roumeliotis, Suzanna R. Hopkins, Carine Ngo, Andrew Lamb, Cornelia Meisenberg, Marlène Garrido, Nicolas Dorvault, Ilirjana Bajrami, Léo Colmet-Daage, Thomas Eychenne, Daphné Morel, Roman M. Chabanon

Supplementary Table from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91bf09169c717b744a215d84d8cf834
https://doi.org/10.1158/0008-5472.22429903.v1

Data from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Autor: Sophie Postel-Vinay, Christopher J. Lord, Jessica A. Downs, Eric Deutsch, Jean-Charles Soria, Geneviève Almouzni, Jyoti S. Choudhary, Raphaël Margueron, Stephen J. Pettitt, Christophe Massard, Elaine Del Nery, Asha Konde, Clémence Astier, Asuka Kawai-Kawachi, Clémence Hénon, Samuel Jouny, Theodoros I. Roumeliotis, Suzanna R. Hopkins, Carine Ngo, Andrew Lamb, Cornelia Meisenberg, Marlène Garrido, Nicolas Dorvault, Ilirjana Bajrami, Léo Colmet-Daage, Thomas Eychenne, Daphné Morel, Roman M. Chabanon

Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell carcinomas (ccRCC). To identify novel therapeutic approaches to targeting PBRM1-defe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6091fc71a7c522b42ba404c337832524
https://doi.org/10.1158/0008-5472.c.6513481.v1

Abstract 6277: Identification of ATR inhibitors as therapeutic opportunities in Desmoplastic small round cell tumors

Autor: Asuka KAWAI-KAWACHI, Madison LENORMAND, Clémence HENON, Thomas EYCHENNE, Leo COLMET-DAAGE, Nicolas DORVAULT, Marlene GARRIDO, Clémence ASTIER, Carine NGO, Helen PEMBERTON, Aditi GULATI, Stephen PETTITT, Roman CHABANON, Christopher J LORD, Sophie POSTEL-VINAY

Publikováno v: Cancer Research. 82:6277-6277

Introduction: Desmoplastic small round cell tumor (DSRCT) is a rare and very aggressive subtype of sarcoma, affecting predominantly young males. DSRCT is molecularly characterized by the t(11;22)(q24;q12) chromosomal translocation, which fuses EWSR1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afe16104d314b83780ae2f2b3f687958
https://doi.org/10.1158/1538-7445.am2022-6277

Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly

Autor: Julie Soutourina, Thomas Eychenne, Michel Werner

Publikováno v: Transcription
Transcription, 2017, 8 (5), pp.328--342. ⟨10.1080/21541264.2017.1329000⟩

Mediator is a multisubunit complex conserved in eukaryotes that plays an essential coregulator role in RNA polymerase (Pol) II transcription. Despite intensive studies of the Mediator complex, the molecular mechanisms of its function in vivo remain t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce010b5cb226721aaf7efd5d063a9cdd
https://hal.archives-ouvertes.fr/hal-02194247

Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture

Autor: Marie-Bénédicte Barrault, Thomas Eychenne, Elizaveta A. Novikova, Pierre Nicolas, David Cornu, Nuno Peixeiro, Laurent Kuras, Olivier Alibert, Virginie Redeker, Julie Soutourina, Claire Boschiero, Michel Werner

Publikováno v: Genes and Development 18 (30), 2119-2132. (2016)
Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2016, 30 (18), pp.2119-2132. ⟨10.1101/gad.285775.116⟩
Genes and Development, Cold Spring Harbor Laboratory Press, 2016, 30 (18), pp.2119-2132. 〈10.1101/gad.285775.116〉
Genes and Development, 2016, 30 (18), pp.2119-2132. ⟨10.1101/gad.285775.116⟩

Mediator is a large coregulator complex conserved from yeast to humans and involved in many human diseases, including cancers. Together with general transcription factors, it stimulates preinitiation complex (PIC) formation and activates RNA polymera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f845ae2306bfb6bd80b645342585cce
http://prodinra.inra.fr/record/382917