Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Thomas Engber"'
Autor:
Sowmya Chollate, Paul H. Weinreb, Fang Qian, Alfred Sandrock, Omar Quintero-Monzon, Thierry Bussiere, Mahin Arastu, Melanie S. Brennan, Mingwei Li, Jan Grimm, Yaming Hang, James Ferrero, Tianle Chen, John O'Gorman, Robert Dunstan, Thomas Engber, Roger M. Nitsch, Marcel Maier, Jeff Sevigny, Ping Chiao, Kenneth J. Rhodes, Alvydas Mikulskis, Yan Ling, Robert H. Scannevin, H. Moore Arnold, Leslie Williams, Christoph Hock, Stephen Salloway
Publikováno v:
Nature
Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6af16349ff35f219bea2af5a81efc0
Autor:
Joy Wang, Deepali Phadke, James E. Dowling, Thomas Engber, Eman Ayyub, Xiaowei Jin, Petter Russell C, Kurt Van Vloten, Jeffrey Vessels, Chang He Xi, Serajul Haque, Gnanasambandam Kumaravel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4809-4813
Potent and selective antagonists of the adenosine A2A receptor often contain a nitrogen-rich fused-ring heterocyclic core. Replacement of the core with an isomeric ring system has previously been shown to improve target affinity, selectivity, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c938546ec38ee5174c45c51f5b3cbef9
https://doi.org/10.1016/j.bmcl.2005.07.052
https://doi.org/10.1016/j.bmcl.2005.07.052
Autor:
Thomas Engber, Gnanasambandam Kumaravel, Pamela Shields, Xiaowei Jin, Chi Vu, Eman Ayyub, Joy Wang, Deepali Phadke, Bo Peng, Petter Russell C
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4835-4838
Piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been shown to be potent and selective adenosine A(2a) receptor antagonists. We now demonstrate that potent and selective A(2a) receptor antagonists could still be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2017e2de719481b84ee4a02a2c9b3bcc
https://doi.org/10.1016/j.bmcl.2004.07.048
https://doi.org/10.1016/j.bmcl.2004.07.048
Autor:
Chi Vu, Petter Russell C, Li Sha, Thomas Engber, Bo Peng, Xiaowei Jin, Deborah Pan, Carol Huang, Jennifer Reilly, Gnanasambandam Kumaravel, Stacy Tam, Deepali Phadke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4831-4834
Piperazine and (R)-2-(aminomethyl)pyrrolidine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been shown to be potent and selective adenosine A(2a) receptor antagonists. We have replaced the triazolotriazine core structure with two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951f299fe51efd0a01c5da3e154c2656
https://doi.org/10.1016/j.bmcl.2004.07.047
https://doi.org/10.1016/j.bmcl.2004.07.047
Autor:
David R. Tomlinson, Jean Dominique Delcroix, Renee I. Shapiro, Rigel Ranciato, Jason D. Freshwater, Frederick R. Taylor, Monica L. Burgers, Andrew P. Mizisin, Thomas Engber, Nigel A. Calcutt, Henryk Dudek, Alicia Middlemas, Alphonse Galdes, Karen L. Allendoerfer, Lee L. Rubin, Kathy Strauch
Publikováno v:
Journal of Clinical Investigation. 111:507-514
Hedgehog proteins modulate development and patterning of the embryonic nervous system. As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the postnatal and adult peripheral nerves, the hedgehog pathway may have a role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4d71bb1ba3b9443143906b4eb35848
https://doi.org/10.1172/jci200315792
https://doi.org/10.1172/jci200315792
Autor:
Alvydas Mikulskis, Kenneth J. Rhodes, Jeff Sevigny, Omar Quintero-Monzon, Melanie S. Brennan, Jan Grimm, Yaming Hang, Tianle Chen, Fang Qian, Marcel Maier, Mingwei Li, Yan Ling, Thomas Engber, Sowmya Chollate, H. Moore Arnold, Leslie Williams, John O'Gorman, Robert H. Scannevin, James Ferrero, Ping Chiao, Paul H. Weinreb, Thierry Bussiere, Christoph Hock, Stephen Salloway, Mahin Arastu, Robert Dunstan, Roger M. Nitsch, Alfred Sandrock
Publikováno v:
Nature. 546:564-564
This corrects the article DOI: 10.1038/nature21361. Erratum for An intermediate-mass black hole in the centre of the globular cluster 47 Tucanae. [Nature. 2017] The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. [Nature. 2016]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890465cbe2de214c95dc72e1432e4f88
https://doi.org/10.1038/nature22809
https://doi.org/10.1038/nature22809
Autor:
H. Arnold, Roger M. Nitsch, Alfred Sandrock, Marcel Maier, Fang Qian, Mahin Arastu, Robert Dunstan, Sowmya Chollate, Melanie S. Brennan, Thomas Engber, Paul H. Weinreb, Jan Grimm, Kenneth J. Rhodes, Robert H. Scannevin, Christoph Hock, Thierry Bussiere, Omar Quintero-Monzon
Publikováno v:
Neurobiology of Aging. 39:S25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::380a9103478d161c4c3589219be69254
https://doi.org/10.1016/j.neurobiolaging.2016.01.111
https://doi.org/10.1016/j.neurobiolaging.2016.01.111
Autor:
Stephane Budel, R. Blake Pepinsky, Jane K. Relton, Stephen M. Strittmatter, Lee Walus, Thomas Engber, Benxiu Ji, Mingwei Li
Publikováno v:
The European journal of neuroscience. 22(3)
Methylprednisolone (MP) is a synthetic glucocorticoid used for the treatment of spinal cord injury (SCI). Soluble Nogo-66 receptor (NgR) ectodomain is a novel experimental therapy for SCI that promotes axonal regeneration by blocking the growth inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c556712a143fd8f328c2a3cbb75e6e03
https://pubmed.ncbi.nlm.nih.gov/16101740
https://pubmed.ncbi.nlm.nih.gov/16101740
Autor:
Jennifer Reilly, Thomas Engber, Xiaowei Jin, Gregg Hetu, Gnanasambandam Kumaravel, Stacy Tam, Deepali Phadke, Carol Huang, Chi Vu, Donna Grant, Deborah Pan, Glenn Smits, Petter Russell C, Bo Peng
Publikováno v:
Journal of medicinal chemistry. 48(6)
The [1,2,4]triazolo[1,5-a]triazine derivative 3, more commonly known in the field of adenosine research as ZM-241385, has previously been demonstrated to be a potent and selective adenosine A2a receptor antagonist, although with limited oral bioavail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e84058ce36c2d930d67a342bc85ec2b
https://pubmed.ncbi.nlm.nih.gov/15771443
https://pubmed.ncbi.nlm.nih.gov/15771443