Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thomas Eick"'
Autor:
Ralf Schmauder, Thomas Eick, Eckhard Schulz, Günther Sammler, Elmar Voigt, Günter Mayer, Holger Ginter, Günter Ditze, Klaus Benndorf
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Ligand-gated ion channels are formed by three to five subunits that control the opening of the pore in a cooperative fashion. We developed a microfluidic chip-based technique for studying ion currents and fluorescence signals in either excis
Externí odkaz:
https://doaj.org/article/22582074603742e0853cab621ad712b1
Autor:
Jana Schirmeyer, Thomas Eick, Eckhard Schulz, Sabine Hummert, Christian Sattler, Ralf Schmauder, Klaus Benndorf
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010376 (2022)
Cyclic nucleotide-gated (CNG) ion channels of olfactory sensory neurons contain three types of homologue subunits, two CNGA2 subunits, one CNGA4 subunit and one CNGB1b subunit. Each subunit carries an intracellular cyclic nucleotide binding domain (C
Externí odkaz:
https://doaj.org/article/ebc7e5e9eecf4c9593cc5cb6b7fb22cd
Autor:
Christian Sattler, Thomas Eick, Sabine Hummert, Eckhard Schulz, Ralf Schmauder, Andrea Schweinitz, Christopher Unzeitig, Frank Schwede, Klaus Benndorf
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Ionotropic purinergic (P2X) receptors are trimeric channels that are activated by the binding of ATP. They are involved in multiple physiological functions, including synaptic transmission, pain and inflammation. The mechanism of activation
Externí odkaz:
https://doaj.org/article/1df92b225dd244dcb0623e62c017f5d8
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1006045 (2018)
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels control electrical rhythmicity in specialized brain and heart cells. We quantitatively analysed voltage-dependent activation of homotetrameric HCN2 channels and its modulation by
Externí odkaz:
https://doaj.org/article/c082d95355f5469fb9645193c93d5ed5
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 4: Article number: 2866 (2013); Published 29 November 2013; Updated 30 March 2018 The original HTML version of this Article had an incorrect article number of 2864; it should have been 2866. This has now been corrected in the HT
Externí odkaz:
https://doaj.org/article/863f12868dc2451a8223dad569598733
A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model
Publikováno v:
Journal of General Physiology. 154
Ligand-gated ion channels are oligomers containing several binding sites for the ligands. However, the signal transmission from the ligand binding site to the pore has not yet been fully elucidated for any of these channels. In heteromeric channels,
Autor:
Eckhard Schulz, Michele Bonus, Christian Sattler, Thomas Zimmer, Melanie Wiegand, Ralf Schmauder, Klaus Benndorf, Nisa Kosmalla, Holger Gohlke, Taulant Kukaj, Thomas Eick, Gunter Ehrlich, Tina Schwabe, Jan L. Münch, Jana Schirmeyer, Sabine Hummert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118
Significance Membrane receptors control innumerous essential functions of living cells and are proven drug targets for pharmacological interventions. Many receptors are composed of a number of subunits and contain multiple binding sites for ligands,
Autor:
Chunjiang Wei, Ziwen Gao, Martina Knabel, Martin Ulbricht, Stefan Senekowitsch, Peter Erfurt, Norman Maggi, Bastian Zwick, Thomas Eickner, Farnaz Matin-Mann, Anne Seidlitz, Thomas Lenarz, Verena Scheper
Publikováno v:
Drug Delivery, Vol 31, Iss 1 (2024)
Background There exists an unfulfilled requirement for effective cochlear pharmacotherapy. Controlled local drug delivery could lead to effective bioavailability. The round window niche (RWN), a cavity in the middle ear, is connected to the cochlea v
Externí odkaz:
https://doaj.org/article/69350fc3c8084ce3bc83da1bb8f1d31b
Autor:
Jennifer Huling, Stefan Oschatz, Helge Lange, Katharina Anna Sterenczak, Thomas Stahnke, Jana Markhoff, Oliver Stachs, Steffen Möller, Nasrullah Undre, Anita Peil, Anselm Jünemann, Niels Grabow, Georg Fuellen, Thomas Eickner
Publikováno v:
Drug Delivery, Vol 31, Iss 1 (2024)
Glaucoma is the leading cause of blindness worldwide. However, its surgical treatment, in particular via trabeculectomy, can be complicated by fibrosis. In current clinical practice, application of the drug, Mitomycin C, prevents or delays fibrosis,
Externí odkaz:
https://doaj.org/article/59ed40cef33a4594b9c1b2336316f4c2
Autor:
Nisa Wongsamitkul, Thomas Eick, Eckhard Schulz, Thomas Zimmer, Ralf Schmauder, Jana Schirmeyer, Sabine Hummert, Vasilica Nache, Klaus Benndorf
Publikováno v:
Scientific Reports. 8
Scientific Reports 6; Article number: 20974; published online: 09 February 2016; updated: 28 June 2018 The Acknowledgements section in this Article is incomplete. “We would like to thank G. Ditze, G. Sammler, F. Horn, M. Händel, K. Schoknecht, S.