Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Thomas E. Richardson"'
Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0f668e1b7d0d3fdf120a40211a6894
https://doi.org/10.1021/acs.jmedchem.1c01087
https://doi.org/10.1021/acs.jmedchem.1c01087
Publikováno v:
Orbit (Amsterdam, Netherlands).
Patients with COVID-19 have been reported to have elevated coagulation factors, which is a well-documented cause of venous thromboembolism events such as deep vein thrombosis and pulmonary embolism. Other venous thrombotic events, however, such as ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde7e1e149f217c784ae219cc313e5eb
https://pubmed.ncbi.nlm.nih.gov/34847834
https://pubmed.ncbi.nlm.nih.gov/34847834
Autor:
Jef K. De Brabander, Margaret A. Phillips, Shuguang Wei, Thomas E. Richardson, Michael Booker, Oleg A. Volkov, Stephen A. Wring, Michael Peel, Ariel Ketcherside, Shihua Zhong, Martin Kramer, Bruce A. Posner, Anthony J. Brockway, Jamie Longgood, Melissa K. McCoy, Jeffrey D. Klinger, Casey C. Cosner
Human African trypanosomiasis (HAT) is a fatal infectious disease caused by the eukaryotic pathogen Trypanosoma brucei. Available treatments are difficult to administer and have significant safety issues. S-Adenosylmethionine decarboxylase (AdoMetDC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba28bc40de3afa0b517260c94d22836
https://europepmc.org/articles/PMC5511061/
https://europepmc.org/articles/PMC5511061/
Autor:
Melanie S. Dugas, David J. Fischer, Selva Nataraja, Andreas Goutopoulos, Mathew Jenks, Foglesong Robert James, Henry Yu, Brian H. Heasley, Xuliang Jiang, Hui Tian, Thomas F. N. Haxell, Jane Li, Pandi Bharathi, Venkataraman Sriraman, Thomas E. Richardson, Stephen S. Palmer, Regina Collis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2168-2172
Follicle-stimulating hormone (FSH), acting on its receptor (FSHR), plays a pivotal role in the stimulation of follicular development and maturation. Multiple injections of protein formulations are used during clinical protocols for ovulation inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa9b8a7a58d2835c548c1632fd29765
https://doi.org/10.1016/j.bmcl.2014.03.018
https://doi.org/10.1016/j.bmcl.2014.03.018
Publikováno v:
Software: Practice and Experience. 44:931-949
Multi-touch driven user interfaces are becoming increasingly prevalent because of their intuitiveness and because of the reduction in the associated hardware costs. In recognition of this trend, multi-touch software frameworks MSFs have begun to emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb4b8699baff7ac498bb0b964d5bb12
https://doi.org/10.1002/spe.2183
https://doi.org/10.1002/spe.2183
Publikováno v:
Chemistry of Heterocyclic Compounds. 34:1382-1385
The synthesis of aziridino[1,2-a]pyrrolidine systems related to the azinomycin family of antitumor agents is reported and was based on an intramolecular addition-elimination reaction sequence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d510e98225aa886acd53c817b4afa09
https://doi.org/10.1007/bf02317807
https://doi.org/10.1007/bf02317807
Publikováno v:
Biochemistry. 33:15298-15308
Flavodoxins mediate electron transfer at low redox potential between the prosthetic groups of other proteins. Interactions between the protein and the flavin mononucleotide cofactor shift both the oxidized/semiquinone and semiquinone/hydroquinone red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76319f531c27d9cf331a486e9b7855e2
https://doi.org/10.1021/bi00255a011
https://doi.org/10.1021/bi00255a011
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47da3fe694657035ee4462b7c6c5693b
https://doi.org/10.1002/chin.199903221
https://doi.org/10.1002/chin.199903221
Publikováno v:
ChemInform. 30
The synthesis of aziridino[1,2-a]pyrrolidine systems related to the azinomycin family of antitumor agents is reported and was based on an intramolecular addition-elimination reaction sequence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd4c896ad8e00e3e139b83295299010
https://doi.org/10.1002/chin.199918103
https://doi.org/10.1002/chin.199918103
Publikováno v:
Evolution; international journal of organic evolution. 46(6)
To examine the effects of maternal and paternal parentage and the size of the pollen load on seed size and weight and on progeny performance we conducted a controlled crossing experiment using a natural population of Campanula americana. We found tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cc96c250f84dcc474b165a5df1e1ff
https://pubmed.ncbi.nlm.nih.gov/28567761
https://pubmed.ncbi.nlm.nih.gov/28567761