Výsledky vyhledávání - "Thomas E. Maar"

The First Immunoglobulin-like Neural Cell Adhesion Molecule (NCAM) Domain Is Involved in Double-reciprocal Interaction with the Second Immunoglobulin-like NCAM Domain and in Heparin Binding

Autor: Thomas E. Maar, Arne Schousboe, Vladislav Soroka, Klaus Edvardsen, Vladimir Berezin, Elisabeth Bock, Vladislav V. Kiselyov

Publikováno v: Journal of Biological Chemistry. 272:10125-10134

To study the function of the first immunoglobulin (Ig)-like domain of the neural cell adhesion molecule (NCAM), it was produced as a recombinant fusion protein in a bacterial expression system and as a recombinant protein in a eukaryotic expression s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aae8996182541be36677b14a54d3b11
https://doi.org/10.1074/jbc.272.15.10125

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Prediction of teratogenic potency of valproate analogues using cerebellar aggregation cultures

Autor: Thomas E. Maar, Ursula Ellerbeck, Vladimir Berezin, Elisabeth Bock, Arne Schousboe, Heinz Nau

Publikováno v: Toxicology. 116:159-168

The aim of this study was to develop a novel in vitro system suitable for preclinical testing for developmental toxicity of drugs. An assay system consisting of primary cultures of dissociated cerebella from 6-day-old mice was chosen, since it allowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a782da87985047414dc02264a87ab51
https://doi.org/10.1016/s0300-483x(96)03538-x

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Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical, hippocampal and cerebellar neurons

Autor: Timothy A. Simeone, H.Steven White, Arne Schousboe, Thomas E. Maar, Virginia Smith-Swintosky, Claus F. Poulsen

Publikováno v: Neurochemical research. 29(1)

The effect of the antiepileptic drug topiramate on Ca2+ uptake through (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate (AMPA) and kainate (KA) receptors was investigated in different cell culture systems consisting of neurons from the cere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9816ec127ec31fca8810231bc7f9bf03
https://pubmed.ncbi.nlm.nih.gov/14992287

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Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of varying potency

Autor: Anna Kawa, Vladimir Berezin, P. Julien, R. Pirovano, Elisabeth Bock, Emma Williams, U. Bojic, Arne Schousboe, Christopher L. Bacon, H. Nau, Patrick Doherty, Ciaran M. Regan, G. Bode, F. Spezia, Frank S. Walsh, U. Ellerbeck, K. Ehlers, Thomas E. Maar

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 12(2)

The in vivo teratogenic potential of valproic acid (VPA) and related teratogenic and non-teratogenic analogues has been correlated with their effects on specific in vitro endpoints of cell proliferation, migration and CAM-dependent neurite outgrowth,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be865c63951e3d0e4496a0661347c120
https://pubmed.ncbi.nlm.nih.gov/20654391

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Functional Characterization of the First Immunoglobulin-Like Domain of The Neural Cell Adhesion Molecule

Autor: Arne Schousboe, Klaus Edvardsen, Vladislav Soroka, Vladislav V. Kiselyov, Vladimir Berezin, Elisabeth Bock, Thomas E. Maar

Publikováno v: Neurochemistry ISBN: 9781461374688

The neural cell adhesion molecule (NCAM) is a cell surface glycoprotein belonging to the immunoglobulin (Ig) superfamily. NCAM is known to mediate cell-cell and cell- substratum interactions (1). In this study, we functionally characterized the Igl N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ec09e0951bbce7a22fb7d72a32c4d70
https://doi.org/10.1007/978-1-4615-5405-9_146

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Functional characterization of NCAM fibronectin type III domains: demonstration of modulatory effects of the proline-rich sequence encoded by alternatively spliced exons a and AAG

Autor: Vladimir Berezin, Christina Kasper, Elisabeth Bock, Klaus Edvardsen, Vladislav Soroka, Vladislav V. Kiselyov, Martin Stahlhut, Thomas E. Maar

Publikováno v: Journal of neuroscience research. 46(2)

In order to characterize the functions of the two fibronectin type III (F3) homology domains of the neural cell adhesion molecule (NCAM), we investigated the effects of two variants, expressed as fusion proteins, of the NCAM-F3 domains on attachment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82f5e37fb4cf1844bccbc053f00ebc9
https://pubmed.ncbi.nlm.nih.gov/8915894

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Taurine Deficiency and Neuronal Migration

Autor: Arne Schousboe, Thomas E. Maar, Herminia Pasantes-Morales, Julio Morán, Georgi Gegelashvili, Elisabeth Bock

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781489901842

Cerebellar granule neurons migrate from the external layer to the internal granule layer along the processes of Bergmann fibers14, 15. It is known from a number of studies that this is a finely modulated process of cell-cell interaction controlled by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6a3f8a35134f04dc604722ea0278066
https://doi.org/10.1007/978-1-4899-0182-8_56

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