Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Thomas E. Dever"'
Autor:
Jinfan Wang, Jing Wang, Byung-Sik Shin, Joo-Ran Kim, Thomas E. Dever, Joseph D. Puglisi, Israel S. Fernández
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The GTPase eIF5B is involved in the correct positioning of the initiator Met-tRNAi Me t on the ribosome during the late stages of translation initiation. Here the authors present a cryo-EM structure of the ribosome in complex with eIF5B and Met-tRNAi
Externí odkaz:
https://doaj.org/article/c83cad0e29c9428c8c5db019de2b15ba
Autor:
Louise C. Gregory, Carolina B. Ferreira, Sara K. Young-Baird, Hywel J. Williams, Magdalena Harakalova, Gijs van Haaften, Sofia A. Rahman, Carles Gaston-Massuet, Daniel Kelberman, GOSgene, Waseem Qasim, Sally A. Camper, Thomas E. Dever, Pratik Shah, Iain C.A.F. Robinson, Mehul T. Dattani
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 470-480 (2019)
Background: The heterotrimeric GTP-binding protein eIF2 forms a ternary complex with initiator methionyl-tRNA and recruits it to the 40S ribosomal subunit for start codon selection and thereby initiates protein synthesis. Mutations in EIF2S3, encodin
Externí odkaz:
https://doaj.org/article/61da4410358e47e8afd4a94b157fdcae
Autor:
Christopher P. Lapointe, Rosslyn Grosely, Masaaki Sokabe, Carlos Alvarado, Jinfan Wang, Elizabeth Montabana, Nancy Villa, Byung-Sik Shin, Thomas E. Dever, Christopher S. Fraser, Israel S. Fernández, Joseph D. Puglisi
Publikováno v:
Nature, vol 607, iss 7917
Nature
Nature
Translation initiation defines the identity and quantity of a synthesized protein. The process is dysregulated in many human diseases1,2. A key commitment step is when the ribosomal subunits join at a translation start site on a messenger RNA to form
Autor:
Pedro Gonzalez-Menendez, Ira Phadke, Meagan E. Olive, Kathy L. McGraw, Jessica Platon, Julien Papoin, Hongxia Yan, Marie Daumur, Franciane Paul, Raghavendra Mirmira, Axel Joly, Jeremy Galtier, Anupama Narla, Guillaume Cartron, Valérie Dardalhon, Valérie S. Zimmermann, Marc Sitbon, Thomas E. Dever, Narla Mohandas, Lydie da Costa, Namrata D. Udeshi, Lionel Blanc, Sandrina Kinet, Naomi Taylor
Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate but it is not known whether the metabolic regulation of protein synthesis controls HSPC differentiation. We discovered that SLC7A1/CAT1-dependent arginine uptake and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a0d8d2d97add40fe9f401959ea1849
https://doi.org/10.1101/2022.03.21.485053
https://doi.org/10.1101/2022.03.21.485053
Autor:
Ivaylo P. Ivanov, James A. Saba, Chen-Ming Fan, Ji Wang, Andrew E. Firth, Chune Cao, Rachel Green, Thomas E. Dever
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Cellular protein synthesis relies on faithful selection of the translation start codon by the ribosome. Initiation at alternative sites on a messenger RNA (mRNA) impairs production of native proteins, triggers synthesis of junk proteins,
Autor:
Matias Wagner, Sara K. Young-Baird, Urania Kotzaeridou, Thomas E. Dever, Tim M. Strom, Vera M. Kalscheuer, Vanessa Suckow, Alexis G. Thornburg, Inga Harting, Stine Christ
Publikováno v:
Clinical Genetics. 98:507-514
Rare pathogenic EIF2S3 missense and terminal deletion variants cause the X-linked intellectual disability (ID) syndrome MEHMO, or a milder phenotype including pancreatic dysfunction and hypopituitarism. We present two unrelated male patients who carr
Autor:
Christopher P. Lapointe, Rosslyn Grosely, Masaaki Sokabe, Carlos Alvarado, Jinfan Wang, Elizabeth Montabana, Nancy Villa, Byung-Sik Shin, Thomas E. Dever, Christopher S. Fraser, Israel S. Fernández, Joseph D. Puglisi
Joining of the ribosomal subunits at a translation start site on a messenger RNA during initiation commits the ribosome to synthesize a protein. Here, we combined single-molecule spectroscopy and structural methods using an in vitro reconstituted sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96c7251689a0aae8948552dda76f4587
https://doi.org/10.1101/2021.12.09.471821
https://doi.org/10.1101/2021.12.09.471821
Autor:
Jinfan Wang, Carlos Alvarado, Byung-Sik Shin, Jonathan Bohlen, Thomas E. Dever, Joseph D. Puglisi
How the eukaryotic 43S preinitiation complex scans along the 5′ untranslated region (5′UTR) of a capped mRNA to locate the correct start codon remains elusive. Here, we directly track yeast 43S-mRNA binding, scanning, and 60S subunit joining by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::455bd065bda57ba97af3c8038feddbea
https://doi.org/10.1101/2021.12.08.471614
https://doi.org/10.1101/2021.12.08.471614
Autor:
Jinfan, Wang, Byung-Sik, Shin, Carlos, Alvarado, Joo-Ran, Kim, Jonathan, Bohlen, Thomas E, Dever, Joseph D, Puglisi
Publikováno v:
Cell. 185:4474-4487.e17
How the eukaryotic 43S preinitiation complex scans along the 5' untranslated region (5' UTR) of a capped mRNA to locate the correct start codon remains elusive. Here, we directly track yeast 43S-mRNA binding, scanning, and 60S subunit joining by real
Autor:
Urania, Kotzaeridou, Sara K, Young-Baird, Vanessa, Suckow, Alexis G, Thornburg, Matias, Wagner, Inga, Harting, Stine, Christ, Tim, Strom, Thomas E, Dever, Vera M, Kalscheuer
Publikováno v:
Clinical Genetics: an international journal of genetics in medicine
Clin. Genet. 98, 507-514 (2020)
Clin Genet
Clin. Genet. 98, 507-514 (2020)
Clin Genet
Rare pathogenic EIF2S3 missense and terminal deletion variants cause the X-linked intellectual disability (ID) syndrome MEHMO, or a milder phenotype including pancreatic dysfunction and hypopituitarism. We present two unrelated male patients who carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::09950c5145d6aae0b22fbe6fa4ed67c4
https://hdl.handle.net/21.11116/0000-0007-817C-C21.11116/0000-0007-AD80-5
https://hdl.handle.net/21.11116/0000-0007-817C-C21.11116/0000-0007-AD80-5