Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Thomas E. Christos"'
Publikováno v:
The Journal of Organic Chemistry. 66:5911-5914
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ee39887692b6597c5b7b990ef1d11a
https://doi.org/10.1021/jo001104v
https://doi.org/10.1021/jo001104v
Publikováno v:
The Journal of Organic Chemistry. 64:9673-9678
A general method for the cyclization of an unactivated 1,1-disubstituted alkene such as 1 to the corresponding cyclopentene 5 is described. Bromination followed by the addition of strong base in the same pot gave the vinyl bromide 3, which reacted fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6430b2b24ba15210dc296d99a768e96
https://doi.org/10.1021/jo991311z
https://doi.org/10.1021/jo991311z
Autor:
Argyrios G. Arvanitis, Paul J. Gilligan, Robert J. Chorvat, Robert S. Cheeseman, Thomas E. Christos, Rajagopal Bakthavatchalam, James P. Beck, Anthony J. Cocuzza, Frank W. Hobbs, Richard G. Wilde, Charles Arnold, Dennis Chidester, Matthew Curry, Liqi He, Andrea Hollis, John Klaczkiewicz, Paul J. Krenitsky, Joseph P. Rescinito, Everett Scholfield, Steven Culp, Errol B. De Souza, Lawrence Fitzgerald, Dimitri Grigoriadis, S. William Tam, Y. Nancy Wong, Shiew-Mei Huang, Helen L. Shen
Publikováno v:
Journal of Medicinal Chemistry. 42:805-818
Screening of our chemical library using a rat corticotropin-releasing hormone (CRH) receptor assay led to the discovery that 2-anilinopyrimidine 15-1 weakly displaced [125I]-0-Tyr-oCRH from rat frontal cortex homogenates when compared to the known pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f81d62a04a50c26bdbe0a34ca2ad02c
https://doi.org/10.1021/jm980222w
https://doi.org/10.1021/jm980222w
Autor:
Paul Krenitsky, Strucely P, Robert Scott Cheeseman, Hodge Carl Nicholas, Thomas E. Christos, Zelda R. Wasserman, Paul J. Gilligan, Ciganek E, Nemeth Ga, Fernandez Ch, Everett Latham Scholfield, Argyrios G. Arvanitis, Aldrich Pe, Robert J. Chorvat
Publikováno v:
Journal of Medicinal Chemistry. 42:819-832
As described in the preceding paper (Arvanitis et al. J. Med. Chem. 1999, 42), anilinopyrimidines I were identified as potent antagonists of corticotropin-releasing hormone-1 receptor (CRH1-R, also referred to as corticotropin-releasing factor, CRF1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bf303a90348d0e84a147404df8be90
https://doi.org/10.1021/jm980223o
https://doi.org/10.1021/jm980223o
Publikováno v:
Expert Opinion on Therapeutic Patents. 8:143-152
Corticotrophin-releasing factor (CRF) receptor antagonists have attracted considerable attention recently as potential therapeutics for a variety of neuropsychiatric disorders including anxiety, depression and anorexia nervosa. Preliminary results su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d6e2b8170f3d8201c86bf229406cae2
https://doi.org/10.1517/13543776.8.2.143
https://doi.org/10.1517/13543776.8.2.143
Autor:
Douglass F. Taber, Thomas E. Christos
Publikováno v:
Tetrahedron Letters. 38:4927-4930
The alkylidene carbene generated by chloromethylenation / α-elimination of 1 proceeds with a high degree of selectivity for methoxy CH insertion over methine insertion, to give 2. The carbene generated with trimethylsilydiazomethane results in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4614b6e4ad294a2dcb210659114f111a
https://doi.org/10.1016/s0040-4039(97)01081-2
https://doi.org/10.1016/s0040-4039(97)01081-2
Publikováno v:
Tetrahedron letters. 51(6)
The preparation of (Z)-1-fluoro-2-bromostyrenes provides a general route for the formation of (Z)-1-fluorostilbene derivatives as configurationally stable spacial linkers for the design of conformationally restricted peptidomimetics. Palladium-cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e182e6e4d8a623f3702fc079b5f20c6
https://pubmed.ncbi.nlm.nih.gov/23397337
https://pubmed.ncbi.nlm.nih.gov/23397337
Publikováno v:
The Journal of Organic Chemistry. 61:2081-2084
A new procedure for cyclohexenone annelation has been developed. Thus, alkylation of 4-isopropylcyclohexanone with allyl bromide gives, over several steps, ketone 8. Exposure to (trimethylsilyl)diazomethane and MeLi smoothly cyclized 8 to the cyclope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae2dd31ec95cbe2cf774b4fc74dc0ddb
https://doi.org/10.1021/jo951949k
https://doi.org/10.1021/jo951949k
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2347-2352
A series of novel cinnamyl and propargyl ether derivatives of alkyl piperidines which show high affinity for sigma and 5HT 2 receptors are described. The ligands exhibit high selectivities for these receptors over D 2 as well as good activity in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460a9d90612531a2617217b18b4d5eb2
https://doi.org/10.1016/0960-894x(94)85038-0
https://doi.org/10.1016/0960-894x(94)85038-0
Autor:
D. E. Grigoriadis, Paul J. Gilligan, Alexander L. Johnson, Gary A. Cain, S. William Tam, Charles J. Eyermann, Thomas E. Christos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:329-334
A series of novel conjugated aromatic 4-amino- and 4-amido-piperidines which are potent sigma receptor ligands are described. These ligands exhibited good to excellent selectivities for binding at sigma versus D2 and 5-HT2 receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f671b10ed60a67a358c3a3049c6b33a
https://doi.org/10.1016/s0960-894x(01)80138-4
https://doi.org/10.1016/s0960-894x(01)80138-4