Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas E. Barta"'
Autor:
Ian S. Cloudsdale, John K. Dickson, Thomas E. Barta, Brian S. Grella, Emilie D. Smith, John L. Kulp, Frank Guarnieri
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:3947-3963
We have applied Simulated Annealing of Chemical Potential (SACP) to a diverse set of ~150 very small molecules to provide insights into new interactions in the binding pocket of human renin, a historically difficult target for which to find low MW in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607e417e3c8454c4652cc73792a132c0
https://doi.org/10.1016/j.bmc.2017.05.032
https://doi.org/10.1016/j.bmc.2017.05.032
Autor:
Thomas E. Barta, Cindy Sutherland, Laura Hagerty, Timothy A.J. Haystead, Douglas H. Weitzel, Philip F. Hughes, Avril V. Somlyo, Christopher N. Fortner, James Marvin Veal, Brittany L. Speer, Jing Ti Deng, Bartosz J. Zieba, Justin A. MacDonald, Aaron S. Franke, Michael P. Walsh, David A. Carlson
Publikováno v:
ACS Chemical Biology. 8:2715-2723
DAPK1 and ZIPK (also called DAPK3) are closely related serine/threonine protein kinases that regulate programmed cell death and phosphorylation of non-muscle and smooth muscle myosin. We have developed a fluorescence linked enzyme chemoproteomic stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1368f024dd488bafab114d019b552fe9
https://doi.org/10.1021/cb400407c
https://doi.org/10.1021/cb400407c
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7c70de96cacfa79847254f63b4d687
https://doi.org/10.1002/chin.199212227
https://doi.org/10.1002/chin.199212227
Publikováno v:
ChemInform. 30
The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7881abfd8e409b38a1115308a132f801
https://doi.org/10.1002/chin.199917129
https://doi.org/10.1002/chin.199917129
Publikováno v:
Tetrahedron Letters. 32:4091-4094
An efficient enantioselective route to the octahydronaphthalene unit present in tetronolide ( 1 ), the stereochemically complex aglycone common to the tetrocarcins, a novel group of antitumor substances, is described. The sequence employs the intramo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c557bdd47a020c7ece932d573e06d1
https://doi.org/10.1016/s0040-4039(00)79871-6
https://doi.org/10.1016/s0040-4039(00)79871-6
Publikováno v:
Tetrahedron Letters. 32:2581-2584
A one-pot two-step phosphorylation procedure is described which is suitable for the preparation of thermally lacible or highly substituted dialkyl phosphonates for use in Horner-Emmons olefinations. Such systems are not readily available using the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1467fbf4e2149feea317d5d99de8337f
https://doi.org/10.1016/s0040-4039(00)78790-9
https://doi.org/10.1016/s0040-4039(00)78790-9
Autor:
Anthony G. M. Barrett, Thomas E. Barta, Michal Sabat, John A. Flygare, Christopher D. Spilling
Publikováno v:
The Journal of Organic Chemistry. 55:2409-2414
La synthese du [«t»-butyldiphenylsiloxy-2' ethylidene-3 methyl-6[methyl-4 trioxa-2,6,7 bicyclo [2.2.2] octyl-1-3 perhydro] benzofurannediol-3a,7, un fragment d'avermectine, a ete effectuee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d69f8e9a065d5a778523cbcb5e53e27
https://doi.org/10.1021/jo00295a032
https://doi.org/10.1021/jo00295a032
Autor:
Thomas E. Barta, et al. et al.
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::213472448e16b9257d5e46b9eaf91d7b
https://doi.org/10.1002/chin.200112094
https://doi.org/10.1002/chin.200112094
Autor:
Anna M. Stevens, Shashi Rao, Louis J. Bedell, Huey-Sheng Shieh, Clara I. Villamil, Grace E. Munie, Thomas E. Barta, Roderick A. Stegeman, Gary A. De Crescenzo, Daniel P. Becker, Joseph J. McDonald
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(24)
A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2936c0c3b342654db058d53b317edd7a
https://pubmed.ncbi.nlm.nih.gov/11133099
https://pubmed.ncbi.nlm.nih.gov/11133099
Autor:
Daniel P. Becker, Thomas E. Barta, Louis J. Bedell, Terri L. Boehm, Brian R. Bond, Jeffery Carroll, Chris P. Carron, Gary A. DeCrescenzo, Alan M. Easton, John N. Freskos, Chris L. Funckes-Shippy, Marcia Heron, Susan Hockerman, Carol Pearcy Howard, James R. Kiefer, Madeleine H. Li, Karl J. Mathis, Joseph J. McDonald, Pramod P. Mehta, Grace E. Munie
Publikováno v:
Journal of Medicinal Chemistry; Sep2010, Vol. 53 Issue 18, p6653-6680, 28p