Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Thomas E Wilson"'
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174041 (2017)
Human alkyladenine DNA glycosylase (AAG) initiates base excision repair (BER) to guard against mutations by excising alkylated and deaminated purines. Counterintuitively, increased expression of AAG has been implicated in increased rates of spontaneo
Externí odkaz:
https://doaj.org/article/f2a0a7a56bae4f4bb9f2813fe3e5be79
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004570 (2014)
The pseudohyphal growth response is a dramatic morphological transition and presumed foraging mechanism wherein yeast cells form invasive and surface-spread multicellular filaments. Pseudohyphal growth has been studied extensively as a model of conse
Externí odkaz:
https://doaj.org/article/4d35c95ef26d438eac15e43d6d75823c
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003599 (2013)
DNA ligase IV (Dnl4 in budding yeast) is a specialized ligase used in non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs). Although point and truncation mutations arise in the human ligase IV syndrome, the roles of Dnl4 in DSB repair
Externí odkaz:
https://doaj.org/article/82e451f331ac4c039f0f5a403d642baf
Autor:
Artur Veloso, Benjamin Biewen, Michelle T Paulsen, Nathan Berg, Leonardo Carmo de Andrade Lima, Jayendra Prasad, Karan Bedi, Brian Magnuson, Thomas E Wilson, Mats Ljungman
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78190 (2013)
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a "cleavable complex". To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show t
Externí odkaz:
https://doaj.org/article/97b0479dfc2d4e018bb6c145b44a99fb
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002981 (2012)
Spontaneous copy number variant (CNV) mutations are an important factor in genomic structural variation, genomic disorders, and cancer. A major class of CNVs, termed nonrecurrent CNVs, is thought to arise by nonhomologous DNA repair mechanisms due to
Externí odkaz:
https://doaj.org/article/65801314a9f9459a919c962c31738e2a
Autor:
John V. Moran, Thomas E. Wilson
Publikováno v:
Cell. 185(20)
Retrotransposons are selfish genetic elements that encode an enzyme, reverse transcriptase (RT), which converts the element-encoded RNA into DNA prior to or during genomic integration. New studies provide compelling evidence that a bacterial group II
Autor:
Brian Magnuson, Karan Bedi, Mats Ljungman, Thomas E. Wilson, Ishwarya Venkata Narayanan, Michelle T. Paulsen
Publikováno v:
RNA. 27:829-840
Pre-mRNA splicing is carried out by the spliceosome and involves splice site recognition, removal of introns, and ligation of exons. Components of the spliceosome have been shown to interact with the elongating RNA polymerase II (RNAPII), which is th
Error-corrected sequencing of genomic targets enriched by probe-based capture has become a standard approach for detecting single-nucleotide variants (SNVs) and small insertion/deletions (indels) present at very low variant allele frequencies. Less a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75ce4a54bc35b3d2b1623f26ae1fc96
https://doi.org/10.1101/2022.07.07.497948
https://doi.org/10.1101/2022.07.07.497948
Autor:
Yui Jin, Natsuko Jin, Yu Oikawa, Ron Benyair, Michiko Koizumi, Thomas E Wilson, Yoshinori Ohsumi, Lois S Weisman
Publikováno v:
EMBO Rep
The vacuole/lysosome plays essential roles in the growth and proliferation of many eukaryotic cells via the activation of target of rapamycin complex 1 (TORC1). Moreover, the yeast vacuole/lysosome is necessary for progression of the cell division cy
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 3, Pp 867-877 (2019)
Clathrin is a major coat protein involved in vesicle formation during endocytosis and transport in the endosomal/trans Golgi system. Clathrin is required for normal growth of yeast (Saccharomyces cerevisiae) and in some genetic backgrounds deletion o