Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Thomas E Wales"'
Autor:
David Yin-wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Publikováno v:
eLife, Vol 12 (2024)
Full-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3–SH2–kinase core. Precisely how the BTK N-terminal domains (the Pleckstrin
Externí odkaz:
https://doaj.org/article/6893fa79a72b4e8bbfd35d28b126c009
Publikováno v:
eLife, Vol 9 (2020)
Bruton’s tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including leukemias and lymphomas. Currently approved BTK inhibitors, including Ibrutinib, a first-in-class covalent inhibitor of BTK, bind directly to the kinase activ
Externí odkaz:
https://doaj.org/article/a1e7c59bd7424b1ea7e5693fd82af544
Autor:
Nikita Chopra, Thomas E Wales, Raji E Joseph, Scott E Boyken, John R Engen, Robert L Jernigan, Amy H Andreotti
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004826 (2016)
Bruton's tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA). Our previous findings showed that the Tec
Externí odkaz:
https://doaj.org/article/1b2db5e585eb47b5abfe08ef3bd48e80
Autor:
Jamie A Moroco, Jodi K Craigo, Roxana E Iacob, Thomas E Wales, John R Engen, Thomas E Smithgall
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105629 (2014)
Src-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of signaling pathways in virtually every cell type. The SFKs share a common negative regulatory mechanism that involves intramolecular interactions of the SH3 d
Externí odkaz:
https://doaj.org/article/e14dcc7fe6fa4ec0a53c9671ea2bcb36
Publikováno v:
Analytical chemistry. 94(28)
During the analysis steps of hydrogen-deuterium exchange (HDX) mass spectrometry (MS), there is an unavoidable loss of deuterons, or back-exchange. Understanding back-exchange is necessary to correct for loss during analysis, to calculate the absolut
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Proteomics data from human cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2426b866d556530901ce4ab6f469c7a7
https://doi.org/10.1158/2159-8290.22532587
https://doi.org/10.1158/2159-8290.22532587
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Supplementary Figures S1-S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea23cd43399e8b35ccc18f1cea0e40ed
https://doi.org/10.1158/2159-8290.22532605
https://doi.org/10.1158/2159-8290.22532605
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Data collection and refinement statistics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f8366377fb78585b44b56e2021cd08
https://doi.org/10.1158/2159-8290.22532602
https://doi.org/10.1158/2159-8290.22532602
Autor:
Thomas E. Wales, Aleksandra Pajak, Alžběta Roeselová, Santosh Shivakumaraswamy, Steven Howell, F. Ulrich Hartl, John R. Engen, David Balchin
The cellular environment is critical for efficient protein maturation, but how proteins fold during biogenesis remains poorly understood. We used hydrogen/deuterium exchange (HDX) mass spectrometry (MS) to define, at peptide resolution, the cotransla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33c19d7da51045713204ed5d76c4b002
https://doi.org/10.1101/2022.09.23.509153
https://doi.org/10.1101/2022.09.23.509153
Autor:
Michelle S. Prew, Christina M. Camara, Thomas Botzanowski, Jamie A. Moroco, Noah B. Bloch, Hannah R. Levy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Gregory H. Bird, Henry D. Herce, Micah A. Gygi, Silvia Escudero, Thomas E. Wales, John R. Engen, Loren D. Walensky
Publikováno v:
Nature Communications. 13
Very long-chain acyl-CoA dehydrogenase (VLCAD) is an inner mitochondrial membrane enzyme that catalyzes the first and rate-limiting step of long-chain fatty acid oxidation. Point mutations in human VLCAD can produce an inborn error of metabolism call