Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle

Autor: Ponvijay eKombairaju, Jaclyn P Kerr, Joseph A Roche, Stephen J.P Pratt, Richard M Lovering, Thomas E Sussan, Jung-Hyun eKim, Guoli eShi, Shyam eBiswal, Christopher William Ward

Publikováno v: Frontiers in Physiology, Vol 5 (2014)

Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we discovered a pathway by which mechanical stretch activates NADPH Oxidase 2 (NoX2) dependent ROS generation (X-ROS). Our work in dystrophic skeletal muscle revea

Externí odkaz: https://doaj.org/article/902b720b7a07474fb6003d5a3c426a46

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice.

Autor: Thomas E Sussan, Jonathan Jun, Rajesh Thimmulappa, Djahida Bedja, Maria Antero, Kathleen L Gabrielson, Vsevolod Y Polotsky, Shyam Biswal

Publikováno v: PLoS ONE, Vol 3, Iss 11, p e3791 (2008)

Oxidative stress and inflammation are two critical factors that drive the formation of plaques in atherosclerosis. Nrf2 is a redox-sensitive transcription factor that upregulates a battery of antioxidative genes and cytoprotective enzymes that consti

Externí odkaz: https://doaj.org/article/16b595d1f4e24c20b7ee07d8c98f47fd

Airborne Particulate Matter Induces Nonallergic Eosinophilic Sinonasal Inflammation in Mice

Autor: Thomas E. Sussan, Sanjay Rajagopalan, Murugappan Ramanathan, Sandra Y. Lin, Elina Toskala, Nitya Surya, Shyam Biswal, Nyall R. London, Xiaoquan Rao, Anuj Tharakan

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 57:59-65

Exposure to airborne particulate matter (PM) has been linked to aggravation of respiratory symptoms, increased risk of cardiovascular disease, and all-cause mortality. Although the health effects of PM on the lower pulmonary airway have been extensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7815aef023edb6553f134c4ec7bfca8
https://doi.org/10.1165/rcmb.2016-0351oc

Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD

Autor: Shyam Biswal, Martin F. Schneider, Thomas E. Sussan, Hegang Chen, Erick O. Hernández-Ochoa, Patrick Robison

Publikováno v: Muscle & Nerve. 56:282-291

Introduction Respiratory and locomotor skeletal muscle dysfunction are common findings in chronic obstructive pulmonary disease (COPD); however, the mechanisms that cause muscle impairment in COPD are unclear. Because Ca2+ signaling in excitation–c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3dc1e70c16b8b31ce51354d7675783c
https://doi.org/10.1002/mus.25466

Field Testing of Alternative Cookstove Performance in a Rural Setting of Western India

Autor: Thomas E. Sussan, D'Ann L. Williams, Sneha Limaye, Sanjay Juvekar, Veena Muralidharan, Shyam Biswal, Patrick N. Breysse, Ana M. Rule, Sundeep Salvi, Kirsten Koehler

Publikováno v: International Journal of Environmental Research and Public Health, Vol 12, Iss 2, Pp 1773-1787 (2015)
International Journal of Environmental Research and Public Health
Volume 12
Issue 2
Pages 1773-1787

Nearly three billion people use solid fuels for cooking and heating, which leads to extremely high levels of household air pollution and is a major cause of morbidity and mortality. Many stove manufacturers have developed alternative cookstoves (ACSs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d831f9a11d8fbe139d45676a245857
http://www.mdpi.com/1660-4601/12/2/1773