Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Thomas E Kehl-Fie"'
Autor:
Jana N Radin, Jessica L Kelliher, Paola K Párraga Solórzano, Kyle P Grim, Rouhallah Ramezanifard, James M Slauch, Thomas E Kehl-Fie
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007971 (2019)
The ability of Staphylococcus aureus and other pathogens to consume glucose is critical during infection. However, glucose consumption increases the cellular demand for manganese sensitizing S. aureus to host-imposed manganese starvation. The current
Externí odkaz:
https://doaj.org/article/7b023c0d80744da4b0ea9daddb491223
Autor:
Yuritzi M Garcia, Anna Barwinska-Sendra, Emma Tarrant, Eric P Skaar, Kevin J Waldron, Thomas E Kehl-Fie
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006125 (2017)
Staphylococcus aureus is a devastating mammalian pathogen for which the development of new therapeutic approaches is urgently needed due to the prevalence of antibiotic resistance. During infection pathogens must overcome the dual threats of host-imp
Externí odkaz:
https://doaj.org/article/e1752d009a5c400cb1d22b1fe3541040
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006040 (2016)
During infection the host imposes manganese and zinc starvation on invading pathogens. Despite this, Staphylococcus aureus and other successful pathogens remain capable of causing devastating disease. However, how these invaders adapt to host-imposed
Externí odkaz:
https://doaj.org/article/b7047a69f1cf48c9a2f99135d8904540
Autor:
Jennifer A Gaddy, Jana N Radin, John T Loh, M Blanca Piazuelo, Thomas E Kehl-Fie, Alberto G Delgado, Florin T Ilca, Richard M Peek, Timothy L Cover, Walter J Chazin, Eric P Skaar, Holly M Scott Algood
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004450 (2014)
Transition metals are necessary for all forms of life including microorganisms, evidenced by the fact that 30% of all proteins are predicted to interact with a metal cofactor. Through a process termed nutritional immunity, the host actively sequester
Externí odkaz:
https://doaj.org/article/ac24f7971a53476f94e4cccfb96bf4d1
Autor:
M Indriati Hood, Brittany L Mortensen, Jessica L Moore, Yaofang Zhang, Thomas E Kehl-Fie, Norie Sugitani, Walter J Chazin, Richard M Caprioli, Eric P Skaar
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1003068 (2012)
Acinetobacter baumannii is an important nosocomial pathogen that accounts for up to 20 percent of infections in intensive care units worldwide. Furthermore, A. baumannii strains have emerged that are resistant to all available antimicrobials. These f
Externí odkaz:
https://doaj.org/article/0981ed8c38d644fd9c72901b787c5f5e
Autor:
Saika Hossain, Jacqueline R Morey, Stephanie L Neville, Katherine Ganio, Jana N Radin, Javiera Norambuena, Jeff M Boyd, Christopher A. McDevitt, Thomas E. Kehl-Fie
Publikováno v:
bioRxiv
Microorganisms can acquire metal ions in metal-limited environments using small molecules called metallophores. While metals and their importers are essential, metals can also be toxic, and metallophores have limited ability to discriminate metals. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcc45b0c132e57b3b30aee289f5b69e
https://europepmc.org/articles/PMC10312489/
https://europepmc.org/articles/PMC10312489/
Autor:
Gilberto C. Padron, Alexander M. Shuppara, Anuradha Sharma, Matthias D. Koch, Jessica-Jae S. Palalay, Jana N. Radin, Thomas E. Kehl-Fie, James A. Imlay, Joseph E. Sanfilippo
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Cells regularly experience fluid flow in natural systems. However, most experimental systems rely on batch cell culture and fail to consider the effect of flow-driven dynamics on cell physiology. Using microfluidics and single-cell imaging, we discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2957aa9c19435ee00b80a14a21c38aa
https://doi.org/10.1073/pnas.2216774120
https://doi.org/10.1073/pnas.2216774120
Publikováno v:
mBio.
The preferred carbon source of Staphylococcus aureus and many other pathogens is glucose, and its consumption is critical during infection. However, glucose utilization increases the cellular demand for manganese, a nutrient sequestered by the host a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba35e7cb3b4f428909740683d01aae8
https://pubmed.ncbi.nlm.nih.gov/36598285
https://pubmed.ncbi.nlm.nih.gov/36598285
Autor:
Gilberto C. Padron, Alexander M. Shuppara, Anuradha Sharma, Matthias D. Koch, Jessica-Jae S. Palalay, Jana N. Radin, Thomas E. Kehl-Fie, James A. Imlay, Joseph E. Sanfilippo
Cells regularly experience fluid flow in natural systems. However, most experimental systems rely on batch cell culture and fail to consider the effect of flow-driven dynamics on cell physiology. Using microfluidics and single-cell imaging, we discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f8e6717c3c3808e22544fbe36cbacf
https://doi.org/10.1101/2022.09.07.506966
https://doi.org/10.1101/2022.09.07.506966
Publikováno v:
Frontiers in Cellular and Infection Microbiology. 12
Metal such as iron, zinc, manganese, and nickel are essential elements for bacteria. These nutrients are required in crucial structural and catalytic roles in biological processes, including precursor biosynthesis, DNA replication, transcription, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998c4d233005eedef5761bfc6eeab120