Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Thomas E Hughes"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 4, p e1010715 (2023)
Leaves comprise a number of different cell-types that are patterned in the context of either the epidermal or inner cell layers. In grass leaves, two distinct anatomies develop in the inner leaf tissues depending on whether the leaf carries out C3 or
Externí odkaz:
https://doaj.org/article/98f2cdf8c5424426848392cf4c819f65
Autor:
Merrilee Thomas, Thomas E Hughes
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0229051 (2020)
Genetically encoded fluorescent biosensors are powerful tools for studying complex signaling in the nervous system, and now both Ca2+ and voltage sensors are available to study the signaling behavior of entire neural circuits. There is a pressing nee
Externí odkaz:
https://doaj.org/article/14046d2eec4e4b97a40f926e678da16a
Deciphering the molecular mechanism responsible for GCaMP6m's Ca2+-dependent change in fluorescence.
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170934 (2017)
The goal of this work is to determine how GCaMP6m's fluorescence is altered in response to Ca2+-binding. Our detailed spectroscopic study reveals the simplest explanation for how GCaMP6m changes fluorescence in response to Ca2+ is with a four-state m
Externí odkaz:
https://doaj.org/article/3e77e6f6b2fb478f89f621207d6b3fce
Autor:
Paul Tewson, Mara Westenberg, Yongxin Zhao, Robert E Campbell, Anne Marie Quinn, Thomas E Hughes
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42791 (2012)
Phospholipase C produces two second messengers--diacylglycerol (DAG), which remains in the membrane, and inositol triphosphate (IP(3)), which triggers the release of calcium ions (Ca(2+)) from intracellular stores. Genetically encoded sensors based o
Externí odkaz:
https://doaj.org/article/d52cb8150fb34a2b950e85cbe4f3272c
Autor:
William D. Figg, Oliver Morgan Hall, Matthew M. Hsieh, Dana K. Furstenau, John F. Tisdale, Cody J. Peer, Naoya Uchida, Thomas E. Hughes
Publikováno v:
Pharmacotherapy
STUDY OBJECTIVE: Alemtuzumab is a monoclonal antibody that targets the cell surface antigen CD52 on lymphocytes. Although it is used for the treatment of hematologic malignancies, such as chronic lymphocytic leukemia, and incorporated into many hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d34d1acba04ff88259ffb3331ce0b2c
https://doi.org/10.1002/phar.2641
https://doi.org/10.1002/phar.2641
Leaves comprise a number of different cell-types that are patterned in the context of either the epidermal or inner cell layers. In grass leaves, two distinct anatomies develop in the inner leaf tissues depending on whether the leaf carries out C3or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12f3b842ffe463d7c2e367a5234553d5
https://doi.org/10.1101/2022.10.28.514209
https://doi.org/10.1101/2022.10.28.514209
Autor:
David F. Stroncek, Alexis Leonard, Sara Hauffe, Courtney D. Fitzhugh, Eoghan Molloy, Thomas E. Hughes, Akshay Sharma, Tiffani Taylor, Megan Wilson, Shengdar Q. Tsai, Naoya Uchida, Jane S. Hankins, John F. Tisdale, Sandhya R. Panch, Kamille A. West, Matthew M. Hsieh, Mitchell J. Weiss
Publikováno v:
Blood Adv
Recent studies suggest that plerixafor mobilization and apheresis in patients with sickle cell disease (SCD) is safe and can allow collection of sufficient CD34+ hematopoietic stem cell (HSC) collection for clinical gene therapy applications. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e3b16cbd02ddd93f04af4a25e746ae
https://doi.org/10.1182/bloodadvances.2021004232
https://doi.org/10.1182/bloodadvances.2021004232
Autor:
Luigi D. Notarangelo, Alexandra F. Freeman, Jennifer S. Wilder, Veena Kapoor, Irini Sereti, Jeffrey I. Cohen, Harry L. Malech, Ronald E. Gress, Jennifer L. Sadler, Jennifer A. Kanakry, Ellen Carroll, Miranda M. Broadney, Jeremy J. Rose, Lauren R. Skeffington, Elizabeth Garabedian, Xiao-Yi Yan, Natalia S. Nunes, Amy P. Hsu, Seth M. Steinberg, Christopher G. Kanakry, Gulbu Uzel, Rochelle Fletcher, Steven M. Holland, Andrea Lisco, William G. Telford, Juan Gea-Banacloche, Nirali N. Shah, Mark Parta, Christa S. Zerbe, Daniel H. Fowler, Stephanie N. Hicks, Dimana Dimitrova, Thomas E. Hughes, Jenny E Blau
Publikováno v:
Biol Blood Marrow Transplant
Allogeneic blood or marrow transplantation (BMT) is a potentially curative therapy for patients with primary immunodeficiency (PID). Safe and effective reduced-intensity conditioning (RIC) approaches that are associated with low toxicity, use alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad197fd92f19071d59ac226e6423628e
https://doi.org/10.1016/j.bbmt.2019.08.018
https://doi.org/10.1016/j.bbmt.2019.08.018
Autor:
Sam R. J. Hoare, Paul H. Tewson, Shivani Sachdev, Mark Connor, Thomas E. Hughes, Anne Marie Quinn
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Neurons integrate inputs over different time and space scales. Fast excitatory synapses at boutons (ms and μm), and slow modulation over entire dendritic arbors (seconds and mm) are all ultimately combined to produce behavior. Understanding the timi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63185a3b4136d90793ea14caabed63d4
http://europepmc.org/articles/PMC8801586
http://europepmc.org/articles/PMC8801586