Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Thomas E Eessalu"'
Autor:
Donald R. Gehlert, Paul Goldsmith, Christian C. Felder, Vanessa N. Barth, Helen E. Sanger, Alex Smith, Rebecca A. Wright, Michael P. Johnson, Adrian J. Mogg, Ellen M. Colvin, Lisa M. Broad, Michael G. Crabtree, Thomas E Eessalu, Douglas A. Schober, Megan Johnson, Cynthia Darshini Jesudason, Hongling Xiao
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 365(3)
In the search for improved symptomatic treatment options for neurodegenerative and neuropsychiatric diseases, muscarinic acetylcholine M1 receptors (M1 mAChRs) have received significant attention. Drug development efforts have identified a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f21b6458eefd29a4ee4fb68d75b91d8
https://pubmed.ncbi.nlm.nih.gov/29643252
https://pubmed.ncbi.nlm.nih.gov/29643252
Autor:
Anne Reifel Miller, Marialuisa C. Marcelo, Qi Chen, Ruth Belin, Pranab Maiti, Joseph V. Haas, Jared L. Piper, Ellen A. Cannady, Steven D. Kahl, Anjana Patel Lewis, Guemalli R. Cardona, Jason T. Johnson, D. Scott Coffey, Dawn A. Brooks, James Ficorilli, Xiaosu Ma, Sweetana Stephanie Ann, Chafiq Hamdouchi, Yanyun Chen, Edward J. Pratt, Keyue Chen, Richard W. Zink, Kelly L. Wilbur, Keith A. Otto, Mark A. Deeg, Nathan Yumibe, Jayana Pankaj Lineswala, Thomas E Eessalu, Chahrzad Montrose-Rafizadeh
Publikováno v:
Journal of medicinal chemistry. 59(24)
The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e874164fca96fc6edd42ba967fc574b
https://pubmed.ncbi.nlm.nih.gov/27749056
https://pubmed.ncbi.nlm.nih.gov/27749056
Autor:
Thomas E. Eessalu, Michael J. Bienkowski, Jason Z. Xu, Steven C. Hebert, Amy E. Hall, L. N. Peterson
Publikováno v:
American Journal of Physiology-Renal Physiology. 273:F739-F748
The ATP-sensitive, inwardly rectifying K+channel, ROMK, has been suggested to be the low-conductance ATP-sensitive K+channel identified in apical membranes of mammalian renal thick ascending limb (TAL) and cortical collecting duct (CCD). Mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3b3db4946ce3dac41efe55ef253312
https://doi.org/10.1152/ajprenal.1997.273.5.f739
https://doi.org/10.1152/ajprenal.1997.273.5.f739
Autor:
Scott E. Truesdell, Robert L. Heinrikson, I M Reardon, Michael J. Bienkowski, Alice L. Laborde, J. A. Shelly, Ann E. Berger, J G Chosay, Thomas E. Eessalu, H A Zurcher-Neely
Publikováno v:
Journal of Biological Chemistry. 265:14505-14511
Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d8307695477d3decbcddad94e5dc19
https://doi.org/10.1016/s0021-9258(18)77331-6
https://doi.org/10.1016/s0021-9258(18)77331-6
Autor:
Martin R. Deibel, Robert L. Heinrikson, Thomas E. Eessalu, Alice L. Laborde, G. A. Waszak, Jerry L. Slightom, Peter K. W. Harris, Michael J. Bienkowski, Colin J. Dunn, Daniel E. Tracey, Che-Shen C. Tomich, L. C. Sieu, J. A. Shelly, J G Chosay, I M Reardon, H. A. Zurcher-Neely, Scott E. Truesdell, M. M. Hardee, Donald B. Carter, Robert N. McEwan, B. M. Taylor, Frank F. Sun, Ann E. Berger, Anthony W. Yem
Publikováno v:
Nature. 344:633-638
A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced. A complementary DNA coding for IRAP was cloned and sequenced. The mature translation product of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e975440c740a1982f0e6402e2f11eb
https://doi.org/10.1038/344633a0
https://doi.org/10.1038/344633a0
Autor:
Philip W. Iversen, Thomas A. Engler, Daniel A. Briere, Eric D. Hawkins, Michael P. Clay, YiHong Burlingame Li, Queener S, O'toole John Cunningham, Robert M. Campbell, Joshua Ryan Clayton, Clive Gideon Diefenbacher, Elizabeth A. Misener, Jon K. Reel, Terry D. Lindstrom, Warren J. Porter, Vaughn R, Brian Eugene Cunningham, Henry, Richard A. Brier, Kelly Wayne Furness, Sushant Malhotra, Burkholder Timothy P, Joseph T. Brozinick, Owens Rebecca Anne, Angela Lynn Marquart, David Mendel, Thomas E Eessalu, Wagner, Mclean Johnathan Alexander
Publikováno v:
Journal of medicinal chemistry. 47(16)
Glycogen synthase kinase-3 (GSK3) is involved in signaling from the insulin receptor. Inhibitors of GSK3 are expected to effect lowering of plasma glucose similar to insulin, making GSK3 an attractive target for the treatment of type 2 diabetes. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fe6d62503568cadbbd9dbb210bf4f3
https://pubmed.ncbi.nlm.nih.gov/15267232
https://pubmed.ncbi.nlm.nih.gov/15267232
Publikováno v:
European journal of immunology. 21(11)
A cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152-residue protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99ec976096e5222fd36cc9c1cd5670f
https://pubmed.ncbi.nlm.nih.gov/1834470
https://pubmed.ncbi.nlm.nih.gov/1834470
Autor:
Thomas E. Eessalu, Virinder K. Moudgil
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 627:301-312
When hen oviduct cytosol samples containing progesterone receptor complexed to [3H]progesterone were incubated with isolated nuclei in presence of 0.2 mM aurintricarboxylic acid, more than 50% inhibition occurred in the uptake of progesterone recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d5806dddb101e13444627f31585f2b
https://doi.org/10.1016/0304-4165(80)90461-4
https://doi.org/10.1016/0304-4165(80)90461-4
Publikováno v:
Journal of Steroid Biochemistry. 22:747-751
Aurintricarboxylic acid (ATA) was immobilized on Sepharose 4B via a carbodiimide coupling mechanism. A majority of the chick oviduct progesterone receptor was retained on the affinity resin and could be recovered upon washing the column with buffer c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5324bde06152cd2c94737b00911bd3cb
https://doi.org/10.1016/0022-4731(85)90281-x
https://doi.org/10.1016/0022-4731(85)90281-x
Autor:
Thomas E. Eessalu, Virinder K. Moudgil
Publikováno v:
Archives of biochemistry and biophysics. 213(1)
Aurintricarboxylic acid (ATA) was used as a low-molecular-weight chemical probe for the analysis of nuclear binding site(s) of avian progesterone receptor. The cytosol from the oviducts of white Leghorn hens or diethylstilbestrol-primed immature chic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e663e2bc70adab200d5fd2735a77e3
https://pubmed.ncbi.nlm.nih.gov/7059192
https://pubmed.ncbi.nlm.nih.gov/7059192