Výsledky vyhledávání - "Thomas E Bickett"

Akademický článek

Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)

Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate the

Externí odkaz: https://doaj.org/article/cbf79a9cbfcd4744b19d4b8a1b088264

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Akademický článek

Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense Against Mycobacterium tuberculosis

Autor: Thomas E. Bickett, Jennifer McLean, Elizabeth Creissen, Linda Izzo, Cassidy Hagan, Antonio J. Izzo, Fabiola Silva Angulo, Angelo A. Izzo

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

The live attenuated Mycobacterium bovis strain, Bacille Calmette Guérin (BCG) is a potent innate immune stimulator. In the C57BL/6 mouse model of tuberculosis, BCG vaccination leads to a significant reduction of Mycobacterium tuberculosis burden aft

Externí odkaz: https://doaj.org/article/ab724926653d4b2286633affba82ccfe

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Supplementary Figure 5 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Autor: Sana D. Karam, Kevin Barry, Eric T. Clambey, Laurel Lenz, Hua Tu, Diemmy Nguyen, Miles Piper, Shiv Bhuvane, Jacob Gadwa, Benjamin Van Court, Shilpa Bhatia, Laurel B. Darragh, Michael Knitz, Thomas E. Bickett

Supplementary Figure 5 (A) IL-15 amounts in serum of Balb/c mice treated with RT, anti-CD25, anti-asialoGM1 to deplete NK cells, and FLT3L; **** p{less than or equal to}0.0001; n=6. (B) Flow cytometric analysis of DCs MOC2 tumors after treatment with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609d23b217c3676dc40cd20e36579925
https://doi.org/10.1158/1078-0432.22481823.v1

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Supplementary Figure 3 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Supplementary Figure 3 (A) MOC2 tumor volumes of mice treated with RT, anti-CD25, and pLEV vehicle control (black line); RT, anti-CD25, and pLEV FLT3L plasmid (green line), and RT + anti-CD25 (red line). n=7. (B) Flow Cytometry analysis of CD8 T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0129797c8f8afeb34c47d4876fdbc3
https://doi.org/10.1158/1078-0432.22481829.v1

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Data from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Purpose:Natural killer (NK) cells are type I innate lymphoid cells that are known for their role in killing virally infected cells or cancer cells through direct cytotoxicity. In addition to direct tumor cell killing, NK cells are known to play funda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68c1fd99fd9e8fbad24ba0eaacca61d
https://doi.org/10.1158/1078-0432.c.6530781.v1

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Supplementary Figure 1 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Supplementary Figure 1 (A) Flow cytometry analysis of NK cell population expression of NKG2A in MOC2 tumors 3 days after RT; n=3. (B). Flow cytometry analysis of NK cell populations in MOC2 tumors 3 days after RT and anti-NKG2A therapy; n=6. (C) Flow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a30cd7d8f02b043d07f33edd8e261dc
https://doi.org/10.1158/1078-0432.22481835

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Supplementary Figure 6 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Supplementary Figure 6 (A) Survival curve comparing patients with high expression of FLT3, the FLT3LG receptor, to patients with low expression of FLT3 expression. (B) Survival curve comparing patients with high expression of FLT3LG to patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9630e81334e4678d472b9e97f07b0844
https://doi.org/10.1158/1078-0432.22481820.v1

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Supplementary Figure 4 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Supplementary Figure 4 (A) Gating strategy used in flow cytometry analysis analyzing NK46+ CD3-NK cells, CD11c+ MHCII+ DCs, CD3+ CD4+ T cells, and CD3+ CD8+ T cells. (B) Flow cytometry analysis of NK cell populations in blood from WT C57BL/6 mice tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c279c121f877e4de9e702e4d8a31665
https://doi.org/10.1158/1078-0432.22481826

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Supplementary Figure 2 from FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Supplementary Figure 2 (A) Flow cytometry analysis of LY2 tumors analyzing DC populations; n=6. (B) Analysis of FLT3L present in the serum of LY2 bearing mice treated with radiation therapy and isotype antibodies, radiation therapy and anti-CD25 anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536c231dc8bfe45ad39697aafc421f45
https://doi.org/10.1158/1078-0432.22481832

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Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC

Autor: Benjamin Van Court, Jacob Gadwa, Diemmy Nguyen, Shiv Bhuvane, Thomas E. Bickett, Laurel L. Lenz, Shilpa Bhatia, Laurel B. Darragh, Ayman Oweida, Alexander L. Dent, Michael W. Knitz, Miles Piper, Andy Phan, Sana D. Karam, Tiffany T. Pham, Sophia Corbo

Publikováno v: Mol Ther

STAT3 signaling has been shown to regulate cellular function and cytokine production in the tumor microenvironment (TME). Within the head and neck squamous cell carcinoma (HNSCC) TME, we previously showed that therapeutic targeting of STAT3 in combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a883b5f80a0b774060ff79a508868af
https://doi.org/10.1016/j.ymthe.2021.11.011

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