Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Thomas E Akie"'
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125617 (2015)
OXPHOS is believed to play an important role in non-alcoholic fatty liver disease (NAFLD), however, precise mechanisms whereby OXPHOS influences lipid homeostasis are incompletely understood. We previously reported that ectopic expression of LRPPRC,
Externí odkaz:
https://doaj.org/article/4a15b74b2c7241fbb6714fcc97b58290
Autor:
Richelle J. Cooper, Thomas E. Akie, Tarika Gujral, Shivam Rana, Kyle Bui, Ryan Factora, Alexandra Quinones, Malkeet Gupta, Gregory W. Hendey, Robert M. Rodriguez, William R. Mower
Publikováno v:
The Lancet Regional Health. Americas, Vol 34, Iss , Pp 100760- (2024)
Summary: Background: Traumatic brain injuries involving the posterior fossa are rare and case reports indicate they often result in severe outcomes. We seek to describe characteristics and outcomes of traumatic posterior fossa injuries. Methods: We p
Externí odkaz:
https://doaj.org/article/2438fc0f8490422b93da861d899a9669
Autor:
Thomas E. Akie, Malkeet Gupta, Robert M. Rodriguez, Gregory W. Hendey, Jake L. Wilson, Alexandra K. Quinones, William R. Mower
Publikováno v:
Annals of emergency medicine.
We evaluated the emergency department providers' ability to detect skull fractures in pediatric patients presenting with blunt head trauma.This was a secondary analysis of the National Emergency X-Radiography Utilization Study (NEXUS) Head computed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35fbb934a8ea69ed4f42366294e009ce
https://pubmed.ncbi.nlm.nih.gov/36328857
https://pubmed.ncbi.nlm.nih.gov/36328857
Autor:
Alan B. Cantor, Inga Hofmann, Vijay G. Sankaran, David A. Williams, Dilnar Mahmut, Mitsutoshi Nakamura, Amy E. Geddis, Nour J. Abdulhay, Susan M. Parkhurst, Jeffrey M. Verboon, Becky Manes, Haydar Frangoul, Stacey Gabriel, Ah Ram Kim, Genevieve M. Crane, Daryl E. Klein, Thomas E. Akie, Namrata Gupta, Meghan E. Kapp, Satish K. Nandakumar
Publikováno v:
Journal of Clinical Immunology
Studies of genetic blood disorders have advanced our understanding of the intrinsic regulation of hematopoiesis. However, such genetic studies have only yielded limited insights into how interactions between hematopoietic cells and their microenviron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79866655865f066a6366d6919aeb3966
http://europepmc.org/articles/PMC7253386
http://europepmc.org/articles/PMC7253386
Autor:
Thomas E. Akie, Siobhan M. Craige, Minwoo Nam, Masato Sanosaka, Marcus P. Cooper, Shashi Kant, John F. Keaney
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Mitochondrial respiration plays a crucial role in determining the metabolic state of brown adipose tissue (BAT), due to its direct roles in thermogenesis, as well as through additional mechanisms. Here, we show that respiration-dependent retrograde s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699dc1489cb4e0ffdc8188193331c3c8
Autor:
Minwoo Nam, Lijun Liu, Thomas E. Akie, David C. Hoaglin, Marcus P. Cooper, Guangping Gao, John F. Keaney, Wei Fan
Publikováno v:
Journal of Clinical Investigation. 124:768-784
Sirtuin 3 (SIRT3), an important regulator of energy metabolism and lipid oxidation, is induced in fasted liver mitochondria and implicated in metabolic syndrome. In fasted liver, SIRT3-mediated increases in substrate flux depend on oxidative phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e86ca8c596d9fdfdb2dfcb27c652a7
https://doi.org/10.1172/jci69413
https://doi.org/10.1172/jci69413
Autor:
Andrew J. Woo, Taylor Piers, Thomas E. Akie, Karen Wieland, Hui Huang, Alan B. Cantor, Jonghwan Kim
Publikováno v:
Journal of Clinical Investigation. 123:3292-3304
About 10% of Down syndrome (DS) infants are born with a transient myeloproliferative disorder (DS-TMD) that spontaneously resolves within the first few months of life. About 20%–30% of these infants subsequently develop acute megakaryoblastic leuke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e5320f76235bb7278ee1d12e2a7bb5
https://doi.org/10.1172/jci40609
https://doi.org/10.1172/jci40609
Autor:
Kimberly A. Negrin, Anouch Matevossian, Marina T. Paul, Rachel J. Roth Flach, Thomas E. Akie, Michael P. Czech
Publikováno v:
Journal of Biological Chemistry. 288:2882-2892
Inflammation induced by wound healing or infection activates local vascular endothelial cells to mediate leukocyte rolling, adhesion, and extravasation by up-regulation of leukocyte adhesion molecules such as E-selectin and P-selectin. Obesity-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e577cf73d5fd8a78943468acfa7242
https://doi.org/10.1074/jbc.m112.412346
https://doi.org/10.1074/jbc.m112.412346
Autor:
Ernest Fraenkel, Andrew J. Woo, Ichiro Taniuchi, Carla F. Kim, Alan B. Cantor, Candace R. Chouinard, Hui Huang, Tali Mazor, Robert G. Roeder, Tyler B. Moran, Adam Labadorf, Sima Zacharek, Hsuan-Ting Huang, Ming Yu, Huafeng Xie, Thomas E. Akie, Katie L. Kathrein, Leonard I. Zon
Publikováno v:
Molecular Cell. 45:330-343
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study we show that Bmi1, a core component of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e550bcff4016b32403c3c2f8b328f5de
https://doi.org/10.1016/j.molcel.2011.11.032
https://doi.org/10.1016/j.molcel.2011.11.032
Autor:
Hanna K. A. Mikkola, Jian Xu, Tobias F. Menne, Ben Van Handel, Guillaume Lettre, Joel N. Hirschhorn, Vijay G. Sankaran, Stuart H. Orkin, Thomas E. Akie, Alan B. Cantor
Publikováno v:
Science. 322:1839-1842
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the β-thalassemia syndromes. Genetic association studies have identified sequence variants in the gene BCL11A that influe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3599433be8d0deaeda285c7c04d0b9c3
https://doi.org/10.1126/science.1165409
https://doi.org/10.1126/science.1165409