Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Thomas Dyrks"'
Autor:
Denise Harhausen, Violetta Sudmann, Uldus Khojasteh, Jochen Müller, Marietta Zille, Keith Graham, Andrea Thiele, Thomas Dyrks, Ulrich Dirnagl, Andreas Wunder
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69529 (2013)
Inflammation is a pathophysiological hallmark of many diseases of the brain. Specific imaging of cells and molecules that contribute to cerebral inflammation is therefore highly desirable, both for research and in clinical application. The 18 kDa tra
Externí odkaz:
https://doaj.org/article/458fd263d1704dd48e33e163ae831af5
Autor:
Ruiqing, Ni, Jennie, Röjdner, Larysa, Voytenko, Thomas, Dyrks, Andrea, Thiele, Amelia, Marutle, Agneta, Nordberg
Publikováno v:
Journal of Alzheimer's Disease
Background: Emerging evidence indicates a central role of gliosis in Alzheimer’s disease (AD) pathophysiology. However, the regional distribution and interaction of astrogliosis and microgliosis in association with amyloid-β (Aβ) still remain unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36cdeee7023a17ee874749bccb1f3cea
https://pubmed.ncbi.nlm.nih.gov/33749648
https://pubmed.ncbi.nlm.nih.gov/33749648
Autor:
Georg Beckmann, Peter St George-Hyslop, Oliver Peters, Lili-Naz Hazrati, Veit Althoff, Murat Eravci, Anette Sommer, Thomas Dyrks, Gerhard Multhaup, John C.S. Breitner, Damian Brockschnieder, Carola G. Schipke, Christian Barucker, Paul E. Fraser, Anja Harmeier
Publikováno v:
Journal of Alzheimer's Disease. 44:613-624
The pathogenesis of Alzheimer's disease (AD) is characterized by the aggregation of amyloid-{beta} (A{beta}) peptides leading to deposition of senile plaques and a progressive decline of cognitive functions, which currently remains the main criterion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6fcb94f91ab79a1fb1737e966a30f8
https://doi.org/10.3233/jad-141902
https://doi.org/10.3233/jad-141902
Autor:
Thomas Dyrks, Damian Brockschnieder, Dae Yoon Chi, Seung Jun Oh, Jae Seung Kim, Hye Rim Kwon, Uthaiwan Sirion, So Young Chu, Chansoo Park, Byoung Se Lee
Publikováno v:
Bioorganicmedicinal chemistry. 24(9)
3-[(18)F]Fluoro-2-hydroxypropyl substituted compounds were synthesized and evaluated as novel (18)F-labeled PET tracers for imaging Aβ plaque in a living brain. All compounds exhibited high binding affinities toward the synthetic Aβ1-42 aggregate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dafa7ec35ca68ccc4a0a5b0488bac27
https://pubmed.ncbi.nlm.nih.gov/27032891
https://pubmed.ncbi.nlm.nih.gov/27032891
Autor:
Matthias Friebe, Jan Andersson, Miklós Tóth, Andrea Varrone, Damian Brockschnieder, Ludger Dinkelborg, Balázs Gulyás, Tobias Heinrich, Heribert Schmitt-Willich, Christer Halldin, Sabine Krause, Thomas Dyrks, Ulf Boemer
Publikováno v:
Journal of Nuclear Medicine. 53:1794-1801
Imaging of amyloid-β (Aβ) plaques by PET is more and more integrated into concepts for Alzheimer disease (AD) diagnosis and drug development. The objective of this study was to find novel chemical entities that can be transformed into 18F-labeled A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd70697dfb7355236fe1b9e5902c000
https://doi.org/10.2967/jnumed.112.104810
https://doi.org/10.2967/jnumed.112.104810
Autor:
Thomas Dyrks, Peter Kasa, Sangram Nag, Ádám Légrádi, Balázs Gulyás, Elena L. Pavlova, Andrea Thiele, Damian Brockschnieder, Karoly Gulya, Christer Halldin, Zsuzsa Beliczai
Publikováno v:
Neurochemistry International. 56:789-798
Earlier post-mortem histological and autoradiographic studies have indicated a reduction of cell numbers in the locus coeruleus (LC) and a corresponding decrease in norepinephrine transporter (NET) in brains obtained from Alzheimer's disease (AD) pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b5ba941232521489b929a1892102e
https://doi.org/10.1016/j.neuint.2010.03.001
https://doi.org/10.1016/j.neuint.2010.03.001
Autor:
Steven Ng, Thomas Dyrks, Victor L. Villemagne, Henri Tochon-Danguy, Christopher C. Rowe, Gerhard Holl, Graeme O'Keefe, Sylvia J. Gong, Ludger Dinkelborg, T. Saunder, J. Gordon Chan, Uwe Ackerman, Stefanie Lindemann
Publikováno v:
Journal of Nuclear Medicine. 50:309-315
Beta-amyloid (Abeta) imaging has great potential to aid in the diagnosis of Alzheimer disease and the development of therapeutics. The radiation dosimetry of Abeta radioligands may influence their application; therefore, we calculated and compared th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7157d1c8f5ac8113a62ce70a3134f87
https://doi.org/10.2967/jnumed.108.055756
https://doi.org/10.2967/jnumed.108.055756
Autor:
Makato Higuchi, Jan Andersson, Andrea Thiele, Boglarka Makkai, Thomas Dyrks, Kazutoshi Suzuki, Balázs Gulyás, Karoly Gulya, Christer Halldin, Szilvia Varszegi, Lidia Bakota, Zsuzsa Beliczai, Tetsua Suhara, Peter Kasa, László Csiba
Publikováno v:
Neurochemistry International. 54:28-36
The binding of two radiolabelled analogues (N-(5-[125I]Iodo-2-phenoxyphenyl)-N-(2,5-dimethoxybenzyl)acetamide ([125I]desfluoro-DAA1106) and N-(5-[125I]Fluoro-2-phenoxyphenyl)-N-(2-[125I]Iodo-5-methoxybenzyl)acetamide ([125I]desmethoxy-DAA1106) of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e627c4b62264ead55f23ac3aac508a09
https://doi.org/10.1016/j.neuint.2008.10.001
https://doi.org/10.1016/j.neuint.2008.10.001
Autor:
Mei-Ping Kung, Matthias Friebe, Kerryn L Pike, Sabine Krause, Christopher C. Rowe, Colin L. Masters, H Kung, Stefanie Lindemann, Thomas Dyrks, Kerryn L Dickinson-Rowe, Wei Zhang, Rachel S. Mulligan, Daniel Skovronsky, H. J. Tochon-Danguy, Graeme O'Keefe, Gordon Chan, Lutz Lehman, William J Browne, Victor L. Villemagne, Uwe Ackerman, Salvatore U Berlangieri, Ludger Dinkelborg, Gareth Jones, Gerhard Holl
Publikováno v:
The Lancet Neurology. 7:129-135
Amyloid-beta (Abeta) plaque formation is a hallmark of Alzheimer's disease (AD) and precedes the onset of dementia. Abeta imaging should allow earlier diagnosis, but clinical application is hindered by the short decay half-life of current Abeta-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc50ced9d51b724840bb5c55d9c33ff
https://doi.org/10.1016/s1474-4422(08)70001-2
https://doi.org/10.1016/s1474-4422(08)70001-2
Autor:
Colin L. Masters, Roberto Cappai, Robert A. Cherny, James A. Duce, Thomas Dyrks, Kevin J. Barnham, Qiao-Xin Li, Ian A. Trounce, Peter J. Crouch, Rachel E. Blake, Giuseppe D. Ciccotosto, Cyril C. Curtain
Publikováno v:
The Journal of Neuroscience. 25:672-679
In studies of Alzheimer's disease pathogenesis there is an increasing focus on mechanisms of intracellular amyloid-β (Aβ) generation and toxicity. Here we investigated the inhibitory potential of the 42 amino acid Aβ peptide (Aβ1-42) on activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fb57ee43e8cc81d37c4ca7ae5598bc
https://doi.org/10.1523/jneurosci.4276-04.2005
https://doi.org/10.1523/jneurosci.4276-04.2005