Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Thomas Duhen"'
Autor:
Thomas Duhen, Venkatesh Rajamanickam, Jianguo Huang, Olivier Fesneau, Wesley Rosales, Kimberly Samson, William Haugh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/d4e66e3eafeb4bf195b405b19aa61bb8
Autor:
Christophe Caux, Olivier Tredan, Thomas Duhen, Christine Ménétrier-Caux, Raphael Schneider, Laurie Besson, Isabelle Treilleux, Yenkel Grinberg-Bleyer, Anthony Di Roio, Margaux Hubert, Marion Bossennec, Céline Rodriguez, Guilhem Lalle, Lyvia Moudombi, Cyril Degletagne, Daniel J Campbell, Séverine Metzger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Multidrug resistance-1 (MDR1) transporter limits the intracellular accumulation of chemotherapies (paclitaxel, anthracyclines) used in breast cancer (BC) treatment. In addition to tumor cells, MDR1 is expressed on immune cell subsets in wh
Externí odkaz:
https://doaj.org/article/5fad6813740d4c719040b8e534d84b00
Autor:
Terry R. Medler, Gwen Kramer, Shelly Bambina, Andrew J. Gunderson, Alejandro Alice, Tiffany Blair, Lauren Zebertavage, Thomas Duhen, Rebekka Duhen, Kristina Young, Marka R. Crittenden, Michael J. Gough
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is associated with improved outcomes in patients. Using genetically engineered mouse pancreat
Externí odkaz:
https://doaj.org/article/71fc1c1f57f6476d9ed4a952100a3793
Autor:
Sjoerd H van der Burg, Rebekka Duhen, Thomas Duhen, Marieke E Ijsselsteijn, Ruud van der Breggen, Koen C M J Peeters, Noel F C C de Miranda, Els M E Verdegaal, Dina Ruano, Manon van der Ploeg, Jitske van den Bulk, Arantza Fariña-Sarasqueta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Expression of CD103 and CD39 has been found to pinpoint tumor-reactive CD8+ T cells in a variety of solid cancers. We aimed to investigate whether these markers specifically identify neoantigen-specific T cells in colorectal cancers (CRCs)
Externí odkaz:
https://doaj.org/article/a80924796f3f43ca978f61b4c5f9bebf
Publikováno v:
Frontiers in Oral Health, Vol 3 (2022)
The clinical response to cancer therapies involves the complex interplay between the systemic, tumoral, and stromal immune response as well as the direct impact of treatments on cancer cells. Each individual's immunological and cancer histories are d
Externí odkaz:
https://doaj.org/article/5aa08b36fb904caf8935237792bf6fa1
Autor:
Rebekka Duhen, Olivier Fesneau, Kimberly A. Samson, Alexandra K. Frye, Michael Beymer, Venkatesh Rajamanickam, David Ross, Eric Tran, Brady Bernard, Andrew D. Weinberg, Thomas Duhen
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
CD4+ Th cells play a key role in orchestrating immune responses, but the identity of the CD4+ Th cells involved in the antitumor immune response remains to be defined. We analyzed the immune cell infiltrates of head and neck squamous cell carcinoma a
Externí odkaz:
https://doaj.org/article/212a102e564b4a79873a285b9f527b64
Autor:
Jitske van den Bulk, Els M. E. Verdegaal, Dina Ruano, Marieke E. Ijsselsteijn, Marten Visser, Ruud van der Breggen, Thomas Duhen, Manon van der Ploeg, Natasja L. de Vries, Jan Oosting, Koen C. M. J. Peeters, Andrew D. Weinberg, Arantza Farina-Sarasqueta, Sjoerd H. van der Burg, Noel F. C. C. de Miranda
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-15 (2019)
Abstract Background The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch repair-deficient tumors having high mutation burden. However, this observation does
Externí odkaz:
https://doaj.org/article/1053242894a246058058f9231a19524f
Autor:
Shay Sharon, Thomas Duhen, Shelly Bambina, Jason Baird, Rom Leidner, Bryan Bell, Nardy Casap, Marka Crittenden, Swetha Vasudevan, Maria Jubran, Nataly Kravchenko-Balasha, Michael Gough
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Patients exhibit distinct responses to immunotherapies that are thought to be linked to their tumor immune environment. However, wide variations in outcomes are also observed in patients with matched baseline tumor environments, indicating that the b
Externí odkaz:
https://doaj.org/article/73dcc246a62349f8a41e6c4a86795fc2
Autor:
Thomas Duhen, Rebekka Duhen, Ryan Montler, Jake Moses, Tarsem Moudgil, Noel F. de Miranda, Cheri P. Goodall, Tiffany C. Blair, Bernard A. Fox, Jason E. McDermott, Shu-Ching Chang, Gary Grunkemeier, Rom Leidner, Richard Bryan Bell, Andrew D. Weinberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Identifying and enumerating tumor-specific CD8 T cells are important for assessing cancer prognosis and therapy efficacy. Here the authors show that CD39 and CD103 mark a subset of tumor-infiltrating CD8 T cells that are tumor-reactive and exhibit ch
Externí odkaz:
https://doaj.org/article/7f90edfb8d4e4077bb1febd57a7e1381
Autor:
Carmen Elena Gómez, Beatriz Perdiguero, Victoria Jiménez, Abdelali Filali-Mouhim, Khader Ghneim, Elias K Haddad, Esther D Quakkelaar, Julie Delaloye, Alexandre Harari, Thierry Roger, Thomas Duhen, Rafick P Sékaly, Cornelis J M Melief, Thierry Calandra, Federica Sallusto, Antonio Lanzavecchia, Ralf Wagner, Giuseppe Pantaleo, Mariano Esteban
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35485 (2012)
Based on the partial efficacy of the HIV/AIDS Thai trial (RV144) with a canarypox vector prime and protein boost, attenuated poxvirus recombinants expressing HIV-1 antigens are increasingly sought as vaccine candidates against HIV/AIDS. Here we descr
Externí odkaz:
https://doaj.org/article/d2fbd70e5f1c483eba57e0bcefc85a23