Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Thomas Desplantez"'
Autor:
Priyanthi Dias, Thomas Desplantez, Majd A El-Harasis, Rasheda A Chowdhury, Nina D Ullrich, Alberto Cabestrero de Diego, Nicholas S Peters, Nicholas J Severs, Kenneth T MacLeod, Emmanuel Dupont
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90266 (2014)
The HL-1 atrial line contains cells blocked at various developmental stages. To obtain homogeneous sub-clones and correlate changes in gene expression with functional alterations, individual clones were obtained and characterised for parameters invol
Externí odkaz:
https://doaj.org/article/9aec14f609514ce7a01cc28c9ee5b472
Autor:
Christopher H. Fry, Nicholas S. Peters, Emmanuel Dupont, Kenneth T. MacLeod, Thomas Desplantez, Rosaire Gray, Nicholas J. Severs, Neil Thomas
Publikováno v:
Thomas, N M, Gray, R, Fry, C H, Desplantez, T, Peters, N S, Severs, N J, Macleod, K T & Dupont, E 2017, ' Functional consequences of co-expressing connexin40 or connexin45 with connexin43 on intercellular electrical coupling ', Biochemical and Biophysical Research Communications, vol. 483, no. 1, pp. 191-196 . https://doi.org/10.1016/j.bbrc.2016.12.169
The functional characteristics of the co-expression of connexin43, connexin40, and connexin45 proteins in human myocardium are thought to play an important role in governing normal propagation of the cardiac electrical impulse and in generating the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe31a4a88a77be4cd149eb150893c09
https://doi.org/10.1016/j.bbrc.2016.12.169
https://doi.org/10.1016/j.bbrc.2016.12.169
Autor:
Edward J. Vigmond, Thomas Desplantez, Natalia A. Trayanova, William H. Franceschi, Claudia Hawks, Marion Constantin, Patrick M. Boyle
Publikováno v:
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2019, 128, pp.117-128. ⟨10.1016/j.yjmcc.2019.01.010⟩
Journal of Molecular and Cellular Cardiology, 2019, 128, pp.117-128. ⟨10.1016/j.yjmcc.2019.01.010⟩
Journal of Molecular and Cellular Cardiology, Elsevier, 2019, 128, pp.117-128. ⟨10.1016/j.yjmcc.2019.01.010⟩
Journal of Molecular and Cellular Cardiology, 2019, 128, pp.117-128. ⟨10.1016/j.yjmcc.2019.01.010⟩
International audience; Cardiac conduction disturbances are linked with arrhythmia development. The concept of safety factor (SF) has been derived to describe the robustness of conduction, but the usefulness of this metric has been constrained by sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4902aa4a355e3f024aed01298ef41c93
https://pubmed.ncbi.nlm.nih.gov/30677394
https://pubmed.ncbi.nlm.nih.gov/30677394
Publikováno v:
Cell Communication & Adhesion. 21:181-191
This review article discusses a recent work using engineered cardiac cells to study the function of the intercalated disc putting emphasis on mechanical and electrical coupling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469e96f91c6441906944bcc5a9652bbd
https://doi.org/10.3109/15419061.2014.905931
https://doi.org/10.3109/15419061.2014.905931
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 8(3)
Cardiac gap junction channels (GJCs) are a passive factor of the regulation of the electrical impulse propagation. They are composed of connexin 40 (Cx40), Cx43, Cx45 and Cx30.2, which own specific expression, localization and electrical properties i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6552d1f6b8f34380d392b4188292bb
Publikováno v:
Pharmacological Research. 65:546-552
Connexin mimetic peptides corresponding to short conserved extracellular loop sequences of connexins have been used widely as reversible inhibitors of gap junctional intercellular communication. These peptides also block movement of ATP and Ca 2+ acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3365400dc590c91f50cdda0f83bac4
https://doi.org/10.1016/j.phrs.2012.02.002
https://doi.org/10.1016/j.phrs.2012.02.002
Autor:
Barbara Rothen-Rutishauser, André G. Kléber, Ghislaine Rigoli, Megan L. McCain, Thomas Desplantez, Kevin Kit Parker, Philippe Beauchamp
Publikováno v:
Desplantez, T; McCain, M L; Beauchamp, P; Rigoli, G; Rothen-Ruthishauser, B; Parker, K K; Kléber, A G (2012). Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexin, and sodium current. Cardiovascular research, 94(1), pp. 58-65. Oxford: Oxford University Press 10.1093/cvr/cvs025
Aims Remodelling and regional gradients in expression of connexins (Cx) are thought to contribute to atrial electrical dysfunction and atrial fibrillation. We assessed the effect of interaction between Cx43, Cx40, and Cx45 on atrial cell-to-cell coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc2999065a6689e6ab8fa9fd1480d2e
https://doi.org/10.1093/cvr/cvs025
https://doi.org/10.1093/cvr/cvs025
Autor:
Cindy W Wong, Jean-Paul Derouette, Brenda R. Kwak, Isabelle Roth, Robert Weingart, Thomas Desplantez
Publikováno v:
Journal of Molecular and Cellular Cardiology, Vol. 46, No 4 (2009) pp. 499-507
A polymorphism in the human Cx37 gene (C1019T), resulting in a non-conservative amino acid change in the regulatory C-terminus of the Cx37 protein (P319S), has been proposed as a prognostic marker for atherosclerosis. We have recently demonstrated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d956f5ed9fc77c5638db2c2ab6a8f1b5
https://doi.org/10.1016/j.yjmcc.2008.12.018
https://doi.org/10.1016/j.yjmcc.2008.12.018
Autor:
José Jalife, Sandeep V. Pandit, Viviana Muñoz, Sergey Mironov, Steven M. Taffet, Krzysztof R. Grzeda, André G. Kléber, Thomas Desplantez, Stephan Rohr
Publikováno v:
Circulation Research. 101:475-483
Previous studies have shown that the gating kinetics of the slow component of the delayed rectifier K + current ( I Ks ) contribute to postrepolarization refractoriness in isolated cardiomyocytes. However, the impact of such kinetics on arrhythmogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa26af0113dba84c39cc208063df011
https://doi.org/10.1161/circresaha.107.149617
https://doi.org/10.1161/circresaha.107.149617
Autor:
Nicholas J. Severs, K. Grikscheit, Nicholas S. Peters, Neil Thomas, Thomas Desplantez, Emmanuel Dupont
Cardiac connexin 43 (Cx43), Cx40 and Cx45 are co-expressed at distinct ratios in myocytes. This pattern is considered a key factor in regulating the gap junction channels composition, properties and function and remains poorly understood. This work a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b86783058062853ad94d1c51c151ded
http://hdl.handle.net/10044/1/39216
http://hdl.handle.net/10044/1/39216
