Výsledky vyhledávání - "Thomas Deckwerth"

DDIS-29. BRAIN-PENETRANT MICROTUBULE-TARGETING AGENT, ST-401, KILLS GLIOBLASTOMA THROUGH A NOVEL MECHANISM

Autor: Michael Wagenbach, Philippe Diaz, Patrick J. Cimino, Juan-Jesus Vicente, Ernest Hamel, Linda Wordeman, Nephi Stella, Rick Gussio, Eric A. Horne, Thomas Deckwerth, Cong Xu, Eric C. Holland, Benjamin Uhlenbruck

Publikováno v: Neuro Oncol

Glioblastomas are particularly sensitive to mitotic disruption when compared with nonmalignant cells and thus microtubule-targeting agents (MTA) represent promising therapeutics to treat patients with glioblastomas; but few such compounds pass the bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a8af72cf425cc5ae6d0b4276bd1422
https://doi.org/10.1093/neuonc/noz175.280

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A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood

Autor: Csaba Szabó, Paul Hill, Edward A Wintner, Christopher Toombs, Michael A Insko, Emily VandenEkart, Asa Bengtsson, Thomas Deckwerth, Dina Leviten, Will Langston, Ronald F. Dumpit

Publikováno v: British Journal of Pharmacology. 160:941-957

Background and purpose: Hydrogen sulphide (H2S) is a labile, endogenous metabolite of cysteine, with multiple biological roles. The development of sulphide-based therapies for human diseases will benefit from a reliable method of quantifying H2S in b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a5cf021fdc8bd18aebfddb1abdb78fd
https://doi.org/10.1111/j.1476-5381.2010.00704.x

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Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide

Autor: Csaba Szabó, Khurram Jamil, Edward A Wintner, Christopher Toombs, Thomas Deckwerth, Michael A Insko, Brahm Goldstein, Helen Usansky, Michael Cooreman

Publikováno v: British Journal of Clinical Pharmacology. 69:626-636

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Hydrogen sulphide (H2S) is a biological mediator and a potential therapeutic agent. In animal studies, the metabolism and pharmacokinetics of H2S have been characterized. WHAT THIS STUDY ADDS • This stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5d9e4bdcfbe5e607c11682eeb1f6b93
https://doi.org/10.1111/j.1365-2125.2010.03636.x

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Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide

Autor: Paul Hill, Christopher Toombs, Michael A Insko, Thomas Deckwerth, Csaba Szabó

Publikováno v: British Journal of Pharmacology. 157:944-951

Background and purpose: Sodium sulphide (Na2S) disassociates to sodium (Na+) hydrosulphide, anion (HS-) and hydrogen sulphide (H2S) in aqueous solutions. Here we have established and characterized a method to detect H2S gas in the exhaled breath of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0130bd14f550c8eb2ff5aeed1d18d06
https://doi.org/10.1111/j.1476-5381.2009.00248.x

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