Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Thomas D. Wright"'
Publikováno v:
Marshall Journal of Medicine, Vol 6, Iss 3, Pp 56-61 (2020)
We present a case of spigelian hernia in a 77-year-old patient to highlight the difficulty in making this diagnosis and to raise awareness of this rare condition among physicians who care for geriatric patients with chronic bouts of abdominal pain
Externí odkaz:
https://doaj.org/article/4ba163a590014e319f3ed577d1b709a5
Autor:
Akshita B. Bhatt, Thomas D. Wright, Van Barnes, Suravi Chakrabarty, Margarite D. Matossian, Erin Lexner, Deniz A. Ucar, Lucio Miele, Patrick T. Flaherty, Matthew E. Burow, Jane E. Cavanaugh
Publikováno v:
Translational Oncology, Vol 14, Iss 6, Pp 101046- (2021)
The epithelial to mesenchymal transition (EMT) is characterized by a loss of cell polarity, a decrease in the epithelial cell marker E-cadherin, and an increase in mesenchymal markers including the zinc-finger E-box binding homeobox (ZEB1). The EMT i
Externí odkaz:
https://doaj.org/article/741a151b8f16497b82667f09411e6156
Autor:
Akshita B. Bhatt, Mohit Gupta, Van T. Hoang, Suravi Chakrabarty, Thomas D. Wright, Steven Elliot, Ishveen K. Chopra, Darlene Monlish, Katie Anna, Matthew E. Burow, Jane E. Cavanaugh, Patrick T. Flaherty
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Epithelial to mesenchymal transition (EMT) is a cellular program that converts non-motile epithelial cells into invasive mesenchymal cells. EMT is implicated in cancer metastasis, chemo-resistance, cancer progression, and generation of cancer stem ce
Externí odkaz:
https://doaj.org/article/df10d63f800f4b54b1e02ff11056280c
Autor:
Van T. Hoang, Jacqueline La, Brian G. Rowan, Saloni Patel, Aaron Buechlein, Matthew E. Burow, Bridgette M. Collins-Burow, Margarite D. Matossian, Lucio Miele, Douglas B. Rusch, Akshita B. Bhatt, Murali Anbalagan, Douglas B. Chrisey, Thomas D. Wright, Jane E. Cavanaugh, Kristine Hoang, Steven Elliott, Patrick T. Flaherty, Kenneth P. Nephew, Deniz A. Ucar, Theresa B. Phamduy, Hope E. Burks
Publikováno v:
Journal of Cellular Biochemistry. 122:835-850
Triple-negative breast cancer (TNBC) presents a clinical challenge due to the aggressive nature of the disease and a lack of targeted therapies. Constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a2097f8e83f57573f0be34b12fd266
https://doi.org/10.1002/jcb.29916
https://doi.org/10.1002/jcb.29916
Autor:
Jane E. Cavanaugh, Darlene Monlish, Suravi Chakrabarty, Christopher Raybuck, Mohit Gupta, Katy Wendekier, Akshita B. Bhatt, Nathan Gartland, Patrick T. Flaherty, Thomas D. Wright, Matthew E. Burow
Publikováno v:
J Cell Biochem
Triple-negative breast cancers (TNBCs) represent 15% to 20% of all breast cancers and are often associated with poor prognosis. The lack of targeted therapies for TNBCs contributes to higher mortality rates. Aberrations in the phosphoinositide-3-kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13db540ef34f3d0e2e48596ba1b6a50
https://doi.org/10.1002/jcb.29350
https://doi.org/10.1002/jcb.29350
Autor:
Thomas D. Wright, Suravi Chakrabarty, Van T. Hoang, Patrick T. Flaherty, Akshita B. Bhatt, Mohit Gupta, Matthew E. Burow, Katie Anna, Jane E. Cavanaugh
Publikováno v:
Cancer Research. 79:P5-08
The organization of cell cytoskeleton is altered in events of epithelial to mesenchymal transition (EMT), promotion of cell motility, and cancer metastases. EMT is associated with decreased cell-cell adhesion, downregulation of epithelial markers lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c25bf68fd691cf31e2355192f879d7c2
https://doi.org/10.1158/1538-7445.sabcs18-p5-08-07
https://doi.org/10.1158/1538-7445.sabcs18-p5-08-07
Autor:
Jane E. Cavanaugh, Patrick T. Flaherty, Lucio Miele, Margarite D. Matossian, Thomas D. Wright, Van Barnes, Matthew E. Burow, Deniz A. Ucar, Suravi Chakrabarty, Akshita B. Bhatt, Erin Lexner
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 6, Pp 101046-(2021)
Translational Oncology, Vol 14, Iss 6, Pp 101046-(2021)
Highlights • ERK1/2 and ERK5 pathway inhibition induces mesenchymal to epithelial transition in breast cancer. • ERK5 is endogenously active and localized in the nucleus of TNBC cells. • Dual ERK5 and ERK1/2 or AKT inhibition is a relevant stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae42aa562776ae0dc9e5bd5217344a1a
https://lirias.kuleuven.be/handle/20.500.12942/707698
https://lirias.kuleuven.be/handle/20.500.12942/707698
Autor:
Van T. Hoang, Ishveen Chopra, Darlene Monlish, Jane E. Cavanaugh, Suravi Chakrabarty, Matthew E. Burow, Mohit Gupta, Thomas D. Wright, Jeffry D. Madura, Mitchel Fedak, Patrick T. Flaherty, Shankar Mannepelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2294-2301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280967542b57df4992adc0733542b790
https://doi.org/10.1016/j.bmcl.2018.05.029
https://doi.org/10.1016/j.bmcl.2018.05.029
Publikováno v:
Cancer Research. 77:P3-07
Aberrations in the MAPK/extracellular signal-regulated kinase (MEK/ERK) and phosphoinositide-3-kinase (PI3K) pathways have been linked to increased proliferation and survival in triple negative breast cancer (TNBC) cells. It has been proposed that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::759e52d49f2dae55e80808d06f299426
https://doi.org/10.1158/1538-7445.sabcs16-p3-07-19
https://doi.org/10.1158/1538-7445.sabcs16-p3-07-19
Autor:
Ishveen Chopra, Darlene Monlish, Steven Elliot, Suravi Chakrabarty, Van T. Hoang, Thomas D. Wright, Akshita B. Bhatt, Jane E. Cavanaugh, Mohit Gupta, Matthew E. Burow, Patrick T. Flaherty, Katie Anna
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology
Frontiers in Oncology
Epithelial to mesenchymal transition (EMT) is a cellular program that converts non-motile epithelial cells into invasive mesenchymal cells. EMT is implicated in cancer metastasis, chemo-resistance, cancer progression, and generation of cancer stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879bc6869cd813bf61a8817d8af0eca4
https://lirias.kuleuven.be/handle/123456789/651143
https://lirias.kuleuven.be/handle/123456789/651143