Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Thomas D. Williams"'
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108732- (2024)
Summary: Proteome adaptation is key to cells surviving stresses. Increased translation of proteasome assembly chaperones (PACs) is critical for increasing proteasome assembly and cell degradative capacity. The endocytic protein Ede1 recruits PAC mRNA
Externí odkaz:
https://doaj.org/article/cd810a6ed88748f8bf9463a3b624677f
Autor:
Thomas D. Williams
Who Is My Neighbor? makes an original, compelling case for human rights as moral entitlements grounded in the dignity of the human person.
SUMMARYEukaryotic cells achieve proteostasis by ensuring their protein requirements are met through tight control of TORC1 activity. Upon TORC1 inhibition, degradative activity is increased, and protein synthesis is reduced through inhibition of tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de7dd9b4e183c83fd5c24108960acc42
https://doi.org/10.1101/2022.12.09.519716
https://doi.org/10.1101/2022.12.09.519716
Autor:
Peggy Paschke, David A Knecht, Augustinas Silale, David Traynor, Thomas D Williams, Peter A Thomason, Robert H Insall, Jonathan R Chubb, Robert R Kay, Douwe M Veltman
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196809 (2018)
Dictyostelium has a mature technology for molecular-genetic manipulation based around transfection using several different selectable markers, marker re-cycling, homologous recombination and insertional mutagenesis, all supported by a well-annotated
Externí odkaz:
https://doaj.org/article/e50838345c6640ac94a37f459c8aab21
Autor:
Douwe M Veltman, Thomas D Williams, Gareth Bloomfield, Bi-Chang Chen, Eric Betzig, Robert H Insall, Robert R Kay
Publikováno v:
eLife, Vol 5 (2016)
Macropinocytosis is a fundamental mechanism that allows cells to take up extracellular liquid into large vesicles. It critically depends on the formation of a ring of protrusive actin beneath the plasma membrane, which develops into the macropinocyti
Externí odkaz:
https://doaj.org/article/65db319e912842dca494acd238a2fdf7
Autor:
Alexander Agrotis, Frederic Lamoliatte, Thomas D Williams, Ailsa Black, Rhuari Horberry, Adrien Rousseau
Publikováno v:
Life Science Alliance. 6:e202201642
The homohexameric p97 complex, composed of Cdc48 subunits in yeast, is a crucial component of protein quality control pathways including ER-associated degradation. The complex acts to segregate protein complexes in an ATP-dependent manner, requiring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4507e48c9d581f7492e9d72dd8f1c08
https://doi.org/10.26508/lsa.202201642
https://doi.org/10.26508/lsa.202201642
Publikováno v:
The International Journal of Developmental Biology. 63:473-483
Macropinocytosis is used by a variety of amoebae for feeding on liquid medium. The amoebae project cups and ruffles from their plasma membrane, driven by actin polymerization, and eventually fuse these back to the membrane, entrapping droplets of med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b306110923a82e6ca2605fd5d447ced
https://doi.org/10.1387/ijdb.190220rk
https://doi.org/10.1387/ijdb.190220rk
Publikováno v:
Biochemical Journal
In a role distinct from and perhaps more ancient than that in signal transduction, PIP3 and Ras help to spatially organize the actin cytoskeleton into macropinocytic cups. These large endocytic structures are extended by actin polymerization from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e9e450d3850f28f075ae43ae1a55a
http://europepmc.org/articles/PMC5813501
http://europepmc.org/articles/PMC5813501
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 374(1765)
Macropinocytosis—the large-scale, non-specific uptake of fluid by cells—is used byDictyostelium discoideumamoebae to obtain nutrients. These cells form circular ruffles around regions of membrane defined by a patch of phosphatidylinositol (3,4,5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f835ba8e1a60e0021106678f303dd995
https://pubmed.ncbi.nlm.nih.gov/30967009
https://pubmed.ncbi.nlm.nih.gov/30967009
Autor:
Peggy, Paschke, David A, Knecht, Thomas D, Williams, Peter A, Thomason, Robert H, Insall, Jonathan R, Chubb, Robert R, Kay, Douwe M, Veltman
Publikováno v:
Journal of Visualized Experiments : JoVE
Dictyostelium discoideum is an intriguing model organism for the study of cell differentiation processes during development, cell signaling, and other important cellular biology questions. The technologies available to genetically manipulate Dictyost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ed8f407d9ed3ea2a2e165d4029dc47b
https://pubmed.ncbi.nlm.nih.gov/30735174
https://pubmed.ncbi.nlm.nih.gov/30735174