Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas D. Sweitzer"'
Autor:
James M. Brase, Thomas S. Rush, Brian J. Bennion, Kevin McLoughlin, Thomas D. Sweitzer, Margaret J. Tse, Jonathan E. Allen, Stacie Calad-Thomson, Claire G. Jeong, Amanda Minnich
Drug-induced liver injury (DILI) is the most common cause of acute liver failure and a frequent reason for withdrawal of candidate drugs during preclinical and clinical testing. An important type of DILI is cholestatic liver injury, caused by buildup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d12110e0bc5b0a03cb79780f563a04
http://arxiv.org/abs/2002.12541
http://arxiv.org/abs/2002.12541
Autor:
Gustavo Arruda Bezerra, Elena Dobrovetsky, Aiping Dong, Almagul Seitova, Lissete Crombett, Lisa M Shewchuk, Annie M Hassell, Sharon M Sweitzer, Thomas D Sweitzer, Patrick J McDevitt, Kyung O Johanson, Karen M Kennedy-Wilson, Doug Cossar, Alexey Bochkarev, Karl Gruber, Sirano Dhe-Paganon
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43019 (2012)
Proline-specific dipeptidyl peptidases (DPPs) are emerging targets for drug development. DPP4 inhibitors are approved in many countries, and other dipeptidyl peptidases are often referred to as DPP4 activity- and/or structure-homologues (DASH). Membe
Externí odkaz:
https://doaj.org/article/9376f8c95b9b47d38a60f33aab898172
Autor:
Hu Li, Hongwei Qi, Brian Donovan, Ming Jiang, Derek D. Poore, Zining Wu, Michael Fischer, Subhas J. Chakravorty, Lawrence Wolfe, Thomas D. Sweitzer, Glenn A. Hofmann
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(2)
Nrf2, a master regulator of the phase II gene response to stress, is kept at low concentrations in the cell through binding to Keap1, an adaptor protein for the Cul3 ubiquitin ligase complex. To identify Nrf2 activators, two separate time-resolved fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c412b192a8a78edb39df6756b4fcfa
https://pubmed.ncbi.nlm.nih.gov/30383469
https://pubmed.ncbi.nlm.nih.gov/30383469
Autor:
Thomas D. Sweitzer, Ed Dul, Quinn Lu, Robert S. Ames, Wensheng Xie, Hu Li, Christina S. Pao, Taylor L. Graham
Publikováno v:
ASSAY and Drug Development Technologies. 10:514-524
Nuclear-factor-E2-related transcription factor 2 (Nrf2) regulates a large panel of Phase II genes and plays an important role in cell survival. Nrf2 activation has been shown as preventing cigarette smoke-induced alveolar enlargement in mice. Therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d29ad14aabc3578c876f193c95e77a
https://doi.org/10.1089/adt.2011.436
https://doi.org/10.1089/adt.2011.436
Autor:
Matthew C. Burns, Kyung O. Johanson, Don T. Fisher, Patrick McDevitt, Vaughan R. Leydon, Patricia A. Elkins, Hongwei Qi, Kurt R. Auger, Paris Ward, Maggie Grimes, Thomas D. Sweitzer, Martin Brandt, Benjamin Schwartz, Yu Xue, Robert H. Sinnamon, Ruth Lehr, Thau F. Ho, Christopher S. Jones, Beth Pietrak, Robert B. Kirkpatrick, Giorgia Vincentini
Publikováno v:
Protein Expression and Purification. 73:167-176
Phosphoinositide 3-kinases have been targeted for therapeutic research because they are key components of a cell signaling cascade controlling proliferation, growth, and survival. Direct activation of the PI3Kalpha pathway contributes to the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5edde4897381c48616dfbf19f6a6a5d
https://doi.org/10.1016/j.pep.2010.05.002
https://doi.org/10.1016/j.pep.2010.05.002
Autor:
Thomas D. Sweitzer, Gatto Gregory J, Elizabeth A. Davenport, Douglas G. Johns, Robert S. Ames, Patricia M. Seitz, Rona Cooper, Fernando Ramón, Lorena A. Kallal
Publikováno v:
SLAS Discovery. 15:388-397
Superoxide affects many normal and pathogenic cellular processes, and the detection of superoxide produced by cells is therefore of interest for potential therapeutic applications. To develop a high-throughput cell-based assay for the detection of ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b907ec6dfede26aa22afa964767af747
https://doi.org/10.1177/1087057109359687
https://doi.org/10.1177/1087057109359687
Autor:
Rosalie Matico, Michael L. Moore, Dennis Murphy, Paul M. Keller, Mark R. Harpel, John A. Krawiec, John J. Trill, Krista B. Goodman, Daryl A. Scherzer, Deyou Sha, Da-Yuan Wang, Thomas D. Sweitzer, Jeffrey A. Lieby, Maria Cichy-Knight, Dominic Suarez, Michael Jaye, Mui Cheung, Eric S. Manas, Dennis Lee, Sarah E. Dowdell, Dean E. McNulty, Benjamin K. Schwartz, Michael Jonathan Bury, Allison K. Dunn, Roland S. Annan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:27-30
Endothelial lipase (EL) activity has been implicated in HDL catabolism, vascular inflammation, and atherogenesis, and inhibitors are therefore expected to be useful for the treatment of cardiovascular disease. Sulfonylfuran urea 1 was identified in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198b3db1ae75b39ec49d7ce6b2d23ed0
https://doi.org/10.1016/j.bmcl.2008.11.033
https://doi.org/10.1016/j.bmcl.2008.11.033
Autor:
G. Alexander Patterson, Benjamin D. Kozower, Donald G. Buerk, Steven M. Albelda, Silvia Muro, Melpo Christofidou-Solomidou, Vladimir R. Muzykantov, Thomas D. Sweitzer, Charalambos C. Solomides
Publikováno v:
Nature Biotechnology. 21:392-398
Vascular immunotargeting may facilitate the rapid and specific delivery of therapeutic agents to endothelial cells. We investigated whether targeting of an antioxidant enzyme, catalase, to the pulmonary endothelium alleviates oxidative stress in an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbaea68d2100d1c45fa88f44bd80798
https://doi.org/10.1038/nbt806
https://doi.org/10.1038/nbt806
Autor:
Annie M. Hassell, Lisa M. Shewchuk, Patrick McDevitt, Elena Dobrovetsky, Lissete Crombett, Thomas D. Sweitzer, Doug Cossar, Aiping Dong, Karen M. Kennedy-Wilson, Sirano Dhe-Paganon, Almagul Seitova, Alexey Bochkarev, Sharon Sweitzer, Karl Gruber, Gustavo Arruda Bezerra, Kyung O. Johanson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e43019 (2012)
PLoS ONE, Vol 7, Iss 8, p e43019 (2012)
Proline-specific dipeptidyl peptidases (DPPs) are emerging targets for drug development. DPP4 inhibitors are approved in many countries, and other dipeptidyl peptidases are often referred to as DPP4 activity- and/or structure-homologues (DASH). Membe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9b7c36c89082cbcba64d66b9a98435
http://europepmc.org/articles/PMC3430648
http://europepmc.org/articles/PMC3430648
Autor:
Da-Yuan Wang, Stacey L. Walsh, Martin J. Scott, Robert S. Ames, Quinn Lu, Daniel J. Krosky, Hu Li, Thomas D. Sweitzer, Sundip Modha, Lisa A. Payne
Publikováno v:
Molecular biotechnology. 39(2)
Cortisol is an important glucocorticoid in humans that regulates many physiological processes. Human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone to cortisol in vivo and has emerged as an appealing therapeutic target fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ad2808f3a07bb12b23a90f59c8ecd9
https://pubmed.ncbi.nlm.nih.gov/18327553
https://pubmed.ncbi.nlm.nih.gov/18327553