Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Thomas D. Stamato"'
Autor:
Gianluca Storci, Silvia Marchionni, Claudio Franceschi, Eleonora Croco, Thomas D. Stamato, Massimiliano Bonafè, Antonello Lorenzini, Christian Sell
Publikováno v:
Biogerontology
In evolutionary terms, life on the planet has taken the form of independently living cells for the majority of time. In comparison, the mammalian radiation is a relatively recent event. The common mammalian ancestor was probably small and short-lived
Autor:
Thomas D. Stamato, Silvia Marchionni, Silvana Hrelia, Antonello Lorenzini, Cristina Angeloni, Martine Bocchini, Claudio Stefanelli, Eleonora Croco, Christian Sell
In order to examine potential differences in genomic stability, we have challenged fibroblasts derived from five different mammalian species of variable longevity with the genotoxic agents, etoposide and neocarzinostatin. We report that cells from lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0587e09960a3d76b772c8befccdc2f3a
http://hdl.handle.net/11581/397589
http://hdl.handle.net/11581/397589
Publikováno v:
Scopus-Elsevier
Aging (Albany NY)
Aging (Albany NY)
We have examined the tolerance of the spindle assembly checkpoint (SAC), as measured by the appearance of tetraploid cells in the presence of a microtubule inhibitor, in a series of primary cell strains derived from species with diverse lifespan and
Publikováno v:
Cell Cycle. 10:3853-3856
All life processes are subject to time constraints. At the cellular level, damage repair and cell cycle arrest are interrelated, allowing sufficient time for repair prior to cell cycle progression. Organisms have evolved so that developmental timing
Autor:
Thomas D. Stamato, Jasmine S. Smith, Maria Tresini, F. Brad Johnson, Christian Sell, Antonello Lorenzini, Vincent J. Cristofalo, Anthony Oliver, Mona Hdeib
Publikováno v:
Mechanisms of Ageing and Development. 130:784-792
The identification of the cellular mechanisms responsible for the wide differences in species lifespan remains one of the major unsolved problems of the biology of aging. We measured the capacity of nuclear protein to recognize DNA double strand brea
Autor:
Guillermo E. Taccioli, Thomas D. Stamato, Jose L. Garcia-Perez, John V. Moran, Tammy A. Morrish, JoAnn Sekiguchi
Publikováno v:
Nature. 446:208-212
Long interspersed element-1 (LINE-1 or L1) elements are abundant, non-long-terminal-repeat (non-LTR) retrotransposons that comprise approximately 17% of human DNA. The average human genome contains approximately 80-100 retrotransposition-competent L1
Autor:
Iraimoudi S. Ayene, Thomas D. Stamato, John E. Biaglow, Cameron J. Koch, Stephen W. Tuttle, John J. Mieyal, Jeremiah J. Donahue
Publikováno v:
Radiation Research. 159:484-494
The major focus of this work was to investigate how altered protein thiol redox homeostasis affects radiation-induced cell death. We used the cells of wild-type CHO cell line K1, the CHO cell line E89, which is null for G6PD activity, and a radiation
Publikováno v:
Nucleic Acids Research. 30:4075-4087
We find that nuclear protein extracts from mammalian cells contain an activity that allows DNA ends to associate with circular pUC18 plasmid DNA. This activity requires the catalytic subunit of DNA-PK (DNA-PKcs) and Ku since it was not observed in mu
Autor:
Mark A. Batzer, Jeremy S. Myers, Nicolas Gilbert, Tammy A. Morrish, Thomas D. Stamato, John V. Moran, Guillermo E. Taccioli, Bethaney J. Vincent
Publikováno v:
Nature Genetics. 31:159-165
Long interspersed elements (LINE-1s) are abundant retrotransposons in mammalian genomes that probably retrotranspose by target site-primed reverse transcription (TPRT). During TPRT, the LINE-1 endonuclease cleaves genomic DNA, freeing a 3' hydroxyl t
Autor:
Iraimoudi S. Ayene, Stanley K. Mauldin, Susan F. Jenkins, John E. Biaglow, Cameron J. Koch, Steven W. Tuttle, Thomas D. Stamato
Publikováno v:
Journal of Biological Chemistry. 277:9929-9935
Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the oxidative pentose phosphate cycle, regulates the NADPH/NADP(+) ratio in eukaryotic cells. G6PD deficiency is one of the most common mutations in humans and is known to cause he